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Phototoxic or Photoprotective?—Advances and Limitations of Titanium (IV) Oxide in Dermal Formulations—A Review

The widespread role of titanium (IV) oxide (TiO(2)) in many industries makes this substance of broad scientific interest. TiO(2) can act as both a photoprotector and photocatalyst, and the potential for its role in both applications increases when present in nanometer-sized crystals. Its sunlight-sc...

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Autores principales: Gackowski, Michał, Osmałek, Tomasz, Froelich, Anna, Otto, Filip, Schneider, Raphaël, Lulek, Janina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179435/
https://www.ncbi.nlm.nih.gov/pubmed/37175865
http://dx.doi.org/10.3390/ijms24098159
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author Gackowski, Michał
Osmałek, Tomasz
Froelich, Anna
Otto, Filip
Schneider, Raphaël
Lulek, Janina
author_facet Gackowski, Michał
Osmałek, Tomasz
Froelich, Anna
Otto, Filip
Schneider, Raphaël
Lulek, Janina
author_sort Gackowski, Michał
collection PubMed
description The widespread role of titanium (IV) oxide (TiO(2)) in many industries makes this substance of broad scientific interest. TiO(2) can act as both a photoprotector and photocatalyst, and the potential for its role in both applications increases when present in nanometer-sized crystals. Its sunlight-scattering properties are used extensively in sunscreens. Furthermore, attempts have been made to incorporate TiO(2) into dermal formulations of photolabile drugs. However, the propensity to generate reactive oxygen species (ROS) rendering this material potentially cytotoxic limits its role. Therefore, modifications of TiO(2) nanoparticles (e.g., its polymorphic form, size, shape, and surface modifications) are used in an effort to reduce its photocatalytic effects. This review provides an overview of the potential risks arising from and opportunities presented by the use of TiO(2) in skin care formulations.
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spelling pubmed-101794352023-05-13 Phototoxic or Photoprotective?—Advances and Limitations of Titanium (IV) Oxide in Dermal Formulations—A Review Gackowski, Michał Osmałek, Tomasz Froelich, Anna Otto, Filip Schneider, Raphaël Lulek, Janina Int J Mol Sci Review The widespread role of titanium (IV) oxide (TiO(2)) in many industries makes this substance of broad scientific interest. TiO(2) can act as both a photoprotector and photocatalyst, and the potential for its role in both applications increases when present in nanometer-sized crystals. Its sunlight-scattering properties are used extensively in sunscreens. Furthermore, attempts have been made to incorporate TiO(2) into dermal formulations of photolabile drugs. However, the propensity to generate reactive oxygen species (ROS) rendering this material potentially cytotoxic limits its role. Therefore, modifications of TiO(2) nanoparticles (e.g., its polymorphic form, size, shape, and surface modifications) are used in an effort to reduce its photocatalytic effects. This review provides an overview of the potential risks arising from and opportunities presented by the use of TiO(2) in skin care formulations. MDPI 2023-05-02 /pmc/articles/PMC10179435/ /pubmed/37175865 http://dx.doi.org/10.3390/ijms24098159 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gackowski, Michał
Osmałek, Tomasz
Froelich, Anna
Otto, Filip
Schneider, Raphaël
Lulek, Janina
Phototoxic or Photoprotective?—Advances and Limitations of Titanium (IV) Oxide in Dermal Formulations—A Review
title Phototoxic or Photoprotective?—Advances and Limitations of Titanium (IV) Oxide in Dermal Formulations—A Review
title_full Phototoxic or Photoprotective?—Advances and Limitations of Titanium (IV) Oxide in Dermal Formulations—A Review
title_fullStr Phototoxic or Photoprotective?—Advances and Limitations of Titanium (IV) Oxide in Dermal Formulations—A Review
title_full_unstemmed Phototoxic or Photoprotective?—Advances and Limitations of Titanium (IV) Oxide in Dermal Formulations—A Review
title_short Phototoxic or Photoprotective?—Advances and Limitations of Titanium (IV) Oxide in Dermal Formulations—A Review
title_sort phototoxic or photoprotective?—advances and limitations of titanium (iv) oxide in dermal formulations—a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179435/
https://www.ncbi.nlm.nih.gov/pubmed/37175865
http://dx.doi.org/10.3390/ijms24098159
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