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Vaginal and Cervical Microbiota Composition in Patients with Endometrial Cancer
According to recent data, changes in the vaginal microbiota could affect the risk of gynaecological cancers. Women suffering from endometrial cancer present significant changes in cervicovaginal microbiota composition. The objective of our study was to characterize the cervicovaginal microbiota of w...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179515/ https://www.ncbi.nlm.nih.gov/pubmed/37175971 http://dx.doi.org/10.3390/ijms24098266 |
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author | Barczyński, Bartłomiej Frąszczak, Karolina Grywalska, Ewelina Kotarski, Jan Korona-Głowniak, Izabela |
author_facet | Barczyński, Bartłomiej Frąszczak, Karolina Grywalska, Ewelina Kotarski, Jan Korona-Głowniak, Izabela |
author_sort | Barczyński, Bartłomiej |
collection | PubMed |
description | According to recent data, changes in the vaginal microbiota could affect the risk of gynaecological cancers. Women suffering from endometrial cancer present significant changes in cervicovaginal microbiota composition. The objective of our study was to characterize the cervicovaginal microbiota of women undergoing hysterectomy due to benign disease, atypical hyperplasia, and endometrial cancer; The study included 96 patients, who undergone surgical treatment due to benign uterine disease, precancerous endometrial lesion, and endometrial cancer. Quantitative and qualitative real-time PCR analysis of DNA isolated from vaginal fornix and endocervical canal samples was performed to detect the 19 most commonly identified microorganisms, including different Lactobacillus spp., Atopobium, Bifidobacterium, Chlamydia, and Gardnerella; At least one of the tested microorganisms was identified in 88.5% of vaginal and 83.3% of cervical samples. Lactobacillus iners was significantly more frequent in patients with benign condition, whereas Dialister pneumosintes and Mobiluncus curtisii was more frequent in cancer patients; Mobiluncus curtisi and Dialister pneumosintes, which were identified as significantly more common in endometrial cancer vaginal samples, may be considered as potential endometrial cancer co-factors which promote/stimulate carcinogenesis. However, the exact mechanism of such activity remains unexplained and requires further investigations. |
format | Online Article Text |
id | pubmed-10179515 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101795152023-05-13 Vaginal and Cervical Microbiota Composition in Patients with Endometrial Cancer Barczyński, Bartłomiej Frąszczak, Karolina Grywalska, Ewelina Kotarski, Jan Korona-Głowniak, Izabela Int J Mol Sci Article According to recent data, changes in the vaginal microbiota could affect the risk of gynaecological cancers. Women suffering from endometrial cancer present significant changes in cervicovaginal microbiota composition. The objective of our study was to characterize the cervicovaginal microbiota of women undergoing hysterectomy due to benign disease, atypical hyperplasia, and endometrial cancer; The study included 96 patients, who undergone surgical treatment due to benign uterine disease, precancerous endometrial lesion, and endometrial cancer. Quantitative and qualitative real-time PCR analysis of DNA isolated from vaginal fornix and endocervical canal samples was performed to detect the 19 most commonly identified microorganisms, including different Lactobacillus spp., Atopobium, Bifidobacterium, Chlamydia, and Gardnerella; At least one of the tested microorganisms was identified in 88.5% of vaginal and 83.3% of cervical samples. Lactobacillus iners was significantly more frequent in patients with benign condition, whereas Dialister pneumosintes and Mobiluncus curtisii was more frequent in cancer patients; Mobiluncus curtisi and Dialister pneumosintes, which were identified as significantly more common in endometrial cancer vaginal samples, may be considered as potential endometrial cancer co-factors which promote/stimulate carcinogenesis. However, the exact mechanism of such activity remains unexplained and requires further investigations. MDPI 2023-05-05 /pmc/articles/PMC10179515/ /pubmed/37175971 http://dx.doi.org/10.3390/ijms24098266 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Barczyński, Bartłomiej Frąszczak, Karolina Grywalska, Ewelina Kotarski, Jan Korona-Głowniak, Izabela Vaginal and Cervical Microbiota Composition in Patients with Endometrial Cancer |
title | Vaginal and Cervical Microbiota Composition in Patients with Endometrial Cancer |
title_full | Vaginal and Cervical Microbiota Composition in Patients with Endometrial Cancer |
title_fullStr | Vaginal and Cervical Microbiota Composition in Patients with Endometrial Cancer |
title_full_unstemmed | Vaginal and Cervical Microbiota Composition in Patients with Endometrial Cancer |
title_short | Vaginal and Cervical Microbiota Composition in Patients with Endometrial Cancer |
title_sort | vaginal and cervical microbiota composition in patients with endometrial cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179515/ https://www.ncbi.nlm.nih.gov/pubmed/37175971 http://dx.doi.org/10.3390/ijms24098266 |
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