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Mitochondrial Dysfunction in the Cardio-Renal Axis

Cardiovascular disease (CVD) frequently complicates chronic kidney disease (CKD). The risk of all-cause mortality increases from 20% to 500% in patients who suffer both conditions; this is referred to as the so-called cardio-renal syndrome (CRS). Preclinical studies have described the key role of mi...

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Autores principales: Mendez-Barbero, Nerea, Oller, Jorge, Sanz, Ana B., Ramos, Adrian M., Ortiz, Alberto, Ruiz-Ortega, Marta, Rayego-Mateos, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179675/
https://www.ncbi.nlm.nih.gov/pubmed/37175915
http://dx.doi.org/10.3390/ijms24098209
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author Mendez-Barbero, Nerea
Oller, Jorge
Sanz, Ana B.
Ramos, Adrian M.
Ortiz, Alberto
Ruiz-Ortega, Marta
Rayego-Mateos, Sandra
author_facet Mendez-Barbero, Nerea
Oller, Jorge
Sanz, Ana B.
Ramos, Adrian M.
Ortiz, Alberto
Ruiz-Ortega, Marta
Rayego-Mateos, Sandra
author_sort Mendez-Barbero, Nerea
collection PubMed
description Cardiovascular disease (CVD) frequently complicates chronic kidney disease (CKD). The risk of all-cause mortality increases from 20% to 500% in patients who suffer both conditions; this is referred to as the so-called cardio-renal syndrome (CRS). Preclinical studies have described the key role of mitochondrial dysfunction in cardiovascular and renal diseases, suggesting that maintaining mitochondrial homeostasis is a promising therapeutic strategy for CRS. In this review, we explore the malfunction of mitochondrial homeostasis (mitochondrial biogenesis, dynamics, oxidative stress, and mitophagy) and how it contributes to the development and progression of the main vascular pathologies that could be affected by kidney injury and vice versa, and how this knowledge may guide the development of novel therapeutic strategies in CRS.
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spelling pubmed-101796752023-05-13 Mitochondrial Dysfunction in the Cardio-Renal Axis Mendez-Barbero, Nerea Oller, Jorge Sanz, Ana B. Ramos, Adrian M. Ortiz, Alberto Ruiz-Ortega, Marta Rayego-Mateos, Sandra Int J Mol Sci Review Cardiovascular disease (CVD) frequently complicates chronic kidney disease (CKD). The risk of all-cause mortality increases from 20% to 500% in patients who suffer both conditions; this is referred to as the so-called cardio-renal syndrome (CRS). Preclinical studies have described the key role of mitochondrial dysfunction in cardiovascular and renal diseases, suggesting that maintaining mitochondrial homeostasis is a promising therapeutic strategy for CRS. In this review, we explore the malfunction of mitochondrial homeostasis (mitochondrial biogenesis, dynamics, oxidative stress, and mitophagy) and how it contributes to the development and progression of the main vascular pathologies that could be affected by kidney injury and vice versa, and how this knowledge may guide the development of novel therapeutic strategies in CRS. MDPI 2023-05-03 /pmc/articles/PMC10179675/ /pubmed/37175915 http://dx.doi.org/10.3390/ijms24098209 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mendez-Barbero, Nerea
Oller, Jorge
Sanz, Ana B.
Ramos, Adrian M.
Ortiz, Alberto
Ruiz-Ortega, Marta
Rayego-Mateos, Sandra
Mitochondrial Dysfunction in the Cardio-Renal Axis
title Mitochondrial Dysfunction in the Cardio-Renal Axis
title_full Mitochondrial Dysfunction in the Cardio-Renal Axis
title_fullStr Mitochondrial Dysfunction in the Cardio-Renal Axis
title_full_unstemmed Mitochondrial Dysfunction in the Cardio-Renal Axis
title_short Mitochondrial Dysfunction in the Cardio-Renal Axis
title_sort mitochondrial dysfunction in the cardio-renal axis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179675/
https://www.ncbi.nlm.nih.gov/pubmed/37175915
http://dx.doi.org/10.3390/ijms24098209
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