Cargando…
Mitochondrial Dysfunction in the Cardio-Renal Axis
Cardiovascular disease (CVD) frequently complicates chronic kidney disease (CKD). The risk of all-cause mortality increases from 20% to 500% in patients who suffer both conditions; this is referred to as the so-called cardio-renal syndrome (CRS). Preclinical studies have described the key role of mi...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179675/ https://www.ncbi.nlm.nih.gov/pubmed/37175915 http://dx.doi.org/10.3390/ijms24098209 |
_version_ | 1785041153846935552 |
---|---|
author | Mendez-Barbero, Nerea Oller, Jorge Sanz, Ana B. Ramos, Adrian M. Ortiz, Alberto Ruiz-Ortega, Marta Rayego-Mateos, Sandra |
author_facet | Mendez-Barbero, Nerea Oller, Jorge Sanz, Ana B. Ramos, Adrian M. Ortiz, Alberto Ruiz-Ortega, Marta Rayego-Mateos, Sandra |
author_sort | Mendez-Barbero, Nerea |
collection | PubMed |
description | Cardiovascular disease (CVD) frequently complicates chronic kidney disease (CKD). The risk of all-cause mortality increases from 20% to 500% in patients who suffer both conditions; this is referred to as the so-called cardio-renal syndrome (CRS). Preclinical studies have described the key role of mitochondrial dysfunction in cardiovascular and renal diseases, suggesting that maintaining mitochondrial homeostasis is a promising therapeutic strategy for CRS. In this review, we explore the malfunction of mitochondrial homeostasis (mitochondrial biogenesis, dynamics, oxidative stress, and mitophagy) and how it contributes to the development and progression of the main vascular pathologies that could be affected by kidney injury and vice versa, and how this knowledge may guide the development of novel therapeutic strategies in CRS. |
format | Online Article Text |
id | pubmed-10179675 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101796752023-05-13 Mitochondrial Dysfunction in the Cardio-Renal Axis Mendez-Barbero, Nerea Oller, Jorge Sanz, Ana B. Ramos, Adrian M. Ortiz, Alberto Ruiz-Ortega, Marta Rayego-Mateos, Sandra Int J Mol Sci Review Cardiovascular disease (CVD) frequently complicates chronic kidney disease (CKD). The risk of all-cause mortality increases from 20% to 500% in patients who suffer both conditions; this is referred to as the so-called cardio-renal syndrome (CRS). Preclinical studies have described the key role of mitochondrial dysfunction in cardiovascular and renal diseases, suggesting that maintaining mitochondrial homeostasis is a promising therapeutic strategy for CRS. In this review, we explore the malfunction of mitochondrial homeostasis (mitochondrial biogenesis, dynamics, oxidative stress, and mitophagy) and how it contributes to the development and progression of the main vascular pathologies that could be affected by kidney injury and vice versa, and how this knowledge may guide the development of novel therapeutic strategies in CRS. MDPI 2023-05-03 /pmc/articles/PMC10179675/ /pubmed/37175915 http://dx.doi.org/10.3390/ijms24098209 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mendez-Barbero, Nerea Oller, Jorge Sanz, Ana B. Ramos, Adrian M. Ortiz, Alberto Ruiz-Ortega, Marta Rayego-Mateos, Sandra Mitochondrial Dysfunction in the Cardio-Renal Axis |
title | Mitochondrial Dysfunction in the Cardio-Renal Axis |
title_full | Mitochondrial Dysfunction in the Cardio-Renal Axis |
title_fullStr | Mitochondrial Dysfunction in the Cardio-Renal Axis |
title_full_unstemmed | Mitochondrial Dysfunction in the Cardio-Renal Axis |
title_short | Mitochondrial Dysfunction in the Cardio-Renal Axis |
title_sort | mitochondrial dysfunction in the cardio-renal axis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179675/ https://www.ncbi.nlm.nih.gov/pubmed/37175915 http://dx.doi.org/10.3390/ijms24098209 |
work_keys_str_mv | AT mendezbarberonerea mitochondrialdysfunctioninthecardiorenalaxis AT ollerjorge mitochondrialdysfunctioninthecardiorenalaxis AT sanzanab mitochondrialdysfunctioninthecardiorenalaxis AT ramosadrianm mitochondrialdysfunctioninthecardiorenalaxis AT ortizalberto mitochondrialdysfunctioninthecardiorenalaxis AT ruizortegamarta mitochondrialdysfunctioninthecardiorenalaxis AT rayegomateossandra mitochondrialdysfunctioninthecardiorenalaxis |