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Molecular Mechanisms Underlying Pluripotency and Self-Renewal of Embryonic Stem Cells
Embryonic stem cells (ESCs) are derived from the inner cell mass (ICM) of the blastocyst. ESCs have two distinctive properties: ability to proliferate indefinitely, a feature referred as “self-renewal”, and to differentiate into different cell types, a peculiar characteristic known as “pluripotency”...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179698/ https://www.ncbi.nlm.nih.gov/pubmed/37176093 http://dx.doi.org/10.3390/ijms24098386 |
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author | Varzideh, Fahimeh Gambardella, Jessica Kansakar, Urna Jankauskas, Stanislovas S. Santulli, Gaetano |
author_facet | Varzideh, Fahimeh Gambardella, Jessica Kansakar, Urna Jankauskas, Stanislovas S. Santulli, Gaetano |
author_sort | Varzideh, Fahimeh |
collection | PubMed |
description | Embryonic stem cells (ESCs) are derived from the inner cell mass (ICM) of the blastocyst. ESCs have two distinctive properties: ability to proliferate indefinitely, a feature referred as “self-renewal”, and to differentiate into different cell types, a peculiar characteristic known as “pluripotency”. Self-renewal and pluripotency of ESCs are finely orchestrated by precise external and internal networks including epigenetic modifications, transcription factors, signaling pathways, and histone modifications. In this systematic review, we examine the main molecular mechanisms that sustain self-renewal and pluripotency in both murine and human ESCs. Moreover, we discuss the latest literature on human naïve pluripotency. |
format | Online Article Text |
id | pubmed-10179698 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101796982023-05-13 Molecular Mechanisms Underlying Pluripotency and Self-Renewal of Embryonic Stem Cells Varzideh, Fahimeh Gambardella, Jessica Kansakar, Urna Jankauskas, Stanislovas S. Santulli, Gaetano Int J Mol Sci Review Embryonic stem cells (ESCs) are derived from the inner cell mass (ICM) of the blastocyst. ESCs have two distinctive properties: ability to proliferate indefinitely, a feature referred as “self-renewal”, and to differentiate into different cell types, a peculiar characteristic known as “pluripotency”. Self-renewal and pluripotency of ESCs are finely orchestrated by precise external and internal networks including epigenetic modifications, transcription factors, signaling pathways, and histone modifications. In this systematic review, we examine the main molecular mechanisms that sustain self-renewal and pluripotency in both murine and human ESCs. Moreover, we discuss the latest literature on human naïve pluripotency. MDPI 2023-05-07 /pmc/articles/PMC10179698/ /pubmed/37176093 http://dx.doi.org/10.3390/ijms24098386 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Varzideh, Fahimeh Gambardella, Jessica Kansakar, Urna Jankauskas, Stanislovas S. Santulli, Gaetano Molecular Mechanisms Underlying Pluripotency and Self-Renewal of Embryonic Stem Cells |
title | Molecular Mechanisms Underlying Pluripotency and Self-Renewal of Embryonic Stem Cells |
title_full | Molecular Mechanisms Underlying Pluripotency and Self-Renewal of Embryonic Stem Cells |
title_fullStr | Molecular Mechanisms Underlying Pluripotency and Self-Renewal of Embryonic Stem Cells |
title_full_unstemmed | Molecular Mechanisms Underlying Pluripotency and Self-Renewal of Embryonic Stem Cells |
title_short | Molecular Mechanisms Underlying Pluripotency and Self-Renewal of Embryonic Stem Cells |
title_sort | molecular mechanisms underlying pluripotency and self-renewal of embryonic stem cells |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179698/ https://www.ncbi.nlm.nih.gov/pubmed/37176093 http://dx.doi.org/10.3390/ijms24098386 |
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