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Molecular Mechanisms Underlying Pluripotency and Self-Renewal of Embryonic Stem Cells

Embryonic stem cells (ESCs) are derived from the inner cell mass (ICM) of the blastocyst. ESCs have two distinctive properties: ability to proliferate indefinitely, a feature referred as “self-renewal”, and to differentiate into different cell types, a peculiar characteristic known as “pluripotency”...

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Detalles Bibliográficos
Autores principales: Varzideh, Fahimeh, Gambardella, Jessica, Kansakar, Urna, Jankauskas, Stanislovas S., Santulli, Gaetano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179698/
https://www.ncbi.nlm.nih.gov/pubmed/37176093
http://dx.doi.org/10.3390/ijms24098386
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author Varzideh, Fahimeh
Gambardella, Jessica
Kansakar, Urna
Jankauskas, Stanislovas S.
Santulli, Gaetano
author_facet Varzideh, Fahimeh
Gambardella, Jessica
Kansakar, Urna
Jankauskas, Stanislovas S.
Santulli, Gaetano
author_sort Varzideh, Fahimeh
collection PubMed
description Embryonic stem cells (ESCs) are derived from the inner cell mass (ICM) of the blastocyst. ESCs have two distinctive properties: ability to proliferate indefinitely, a feature referred as “self-renewal”, and to differentiate into different cell types, a peculiar characteristic known as “pluripotency”. Self-renewal and pluripotency of ESCs are finely orchestrated by precise external and internal networks including epigenetic modifications, transcription factors, signaling pathways, and histone modifications. In this systematic review, we examine the main molecular mechanisms that sustain self-renewal and pluripotency in both murine and human ESCs. Moreover, we discuss the latest literature on human naïve pluripotency.
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spelling pubmed-101796982023-05-13 Molecular Mechanisms Underlying Pluripotency and Self-Renewal of Embryonic Stem Cells Varzideh, Fahimeh Gambardella, Jessica Kansakar, Urna Jankauskas, Stanislovas S. Santulli, Gaetano Int J Mol Sci Review Embryonic stem cells (ESCs) are derived from the inner cell mass (ICM) of the blastocyst. ESCs have two distinctive properties: ability to proliferate indefinitely, a feature referred as “self-renewal”, and to differentiate into different cell types, a peculiar characteristic known as “pluripotency”. Self-renewal and pluripotency of ESCs are finely orchestrated by precise external and internal networks including epigenetic modifications, transcription factors, signaling pathways, and histone modifications. In this systematic review, we examine the main molecular mechanisms that sustain self-renewal and pluripotency in both murine and human ESCs. Moreover, we discuss the latest literature on human naïve pluripotency. MDPI 2023-05-07 /pmc/articles/PMC10179698/ /pubmed/37176093 http://dx.doi.org/10.3390/ijms24098386 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Varzideh, Fahimeh
Gambardella, Jessica
Kansakar, Urna
Jankauskas, Stanislovas S.
Santulli, Gaetano
Molecular Mechanisms Underlying Pluripotency and Self-Renewal of Embryonic Stem Cells
title Molecular Mechanisms Underlying Pluripotency and Self-Renewal of Embryonic Stem Cells
title_full Molecular Mechanisms Underlying Pluripotency and Self-Renewal of Embryonic Stem Cells
title_fullStr Molecular Mechanisms Underlying Pluripotency and Self-Renewal of Embryonic Stem Cells
title_full_unstemmed Molecular Mechanisms Underlying Pluripotency and Self-Renewal of Embryonic Stem Cells
title_short Molecular Mechanisms Underlying Pluripotency and Self-Renewal of Embryonic Stem Cells
title_sort molecular mechanisms underlying pluripotency and self-renewal of embryonic stem cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179698/
https://www.ncbi.nlm.nih.gov/pubmed/37176093
http://dx.doi.org/10.3390/ijms24098386
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