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Mitochondria-Targeted Fluorescent Nanoparticles with Large Stokes Shift for Long-Term BioImaging
Mitochondria (MITO) play a significant role in various physiological processes and are a key organelle associated with different human diseases including cancer, diabetes mellitus, atherosclerosis, Alzheimer’s disease, etc. Thus, detecting the activity of MITO in real time is becoming more and more...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179964/ https://www.ncbi.nlm.nih.gov/pubmed/37175369 http://dx.doi.org/10.3390/molecules28093962 |
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author | Li, Xiao Zhang, Tao Diao, Xuebo Li, Yu Su, Yue Yang, Jiapei Shang, Zibo Liu, Shuai Zhou, Jia Li, Guolin Chi, Huirong |
author_facet | Li, Xiao Zhang, Tao Diao, Xuebo Li, Yu Su, Yue Yang, Jiapei Shang, Zibo Liu, Shuai Zhou, Jia Li, Guolin Chi, Huirong |
author_sort | Li, Xiao |
collection | PubMed |
description | Mitochondria (MITO) play a significant role in various physiological processes and are a key organelle associated with different human diseases including cancer, diabetes mellitus, atherosclerosis, Alzheimer’s disease, etc. Thus, detecting the activity of MITO in real time is becoming more and more important. Herein, a novel class of amphiphilic aggregation-induced emission (AIE) active probe fluorescence (AC-QC nanoparticles) based on a quinoxalinone scaffold was developed for imaging MITO. AC-QC nanoparticles possess an excellent ability to monitor MITO in real-time. This probe demonstrated the following advantages: (1) lower cytotoxicity; (2) superior photostability; and (3) good performance in long-term imaging in vitro. Each result of these indicates that self-assembled AC-QC nanoparticles can be used as effective and promising MITO-targeted fluorescent probes. |
format | Online Article Text |
id | pubmed-10179964 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101799642023-05-13 Mitochondria-Targeted Fluorescent Nanoparticles with Large Stokes Shift for Long-Term BioImaging Li, Xiao Zhang, Tao Diao, Xuebo Li, Yu Su, Yue Yang, Jiapei Shang, Zibo Liu, Shuai Zhou, Jia Li, Guolin Chi, Huirong Molecules Article Mitochondria (MITO) play a significant role in various physiological processes and are a key organelle associated with different human diseases including cancer, diabetes mellitus, atherosclerosis, Alzheimer’s disease, etc. Thus, detecting the activity of MITO in real time is becoming more and more important. Herein, a novel class of amphiphilic aggregation-induced emission (AIE) active probe fluorescence (AC-QC nanoparticles) based on a quinoxalinone scaffold was developed for imaging MITO. AC-QC nanoparticles possess an excellent ability to monitor MITO in real-time. This probe demonstrated the following advantages: (1) lower cytotoxicity; (2) superior photostability; and (3) good performance in long-term imaging in vitro. Each result of these indicates that self-assembled AC-QC nanoparticles can be used as effective and promising MITO-targeted fluorescent probes. MDPI 2023-05-08 /pmc/articles/PMC10179964/ /pubmed/37175369 http://dx.doi.org/10.3390/molecules28093962 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Li, Xiao Zhang, Tao Diao, Xuebo Li, Yu Su, Yue Yang, Jiapei Shang, Zibo Liu, Shuai Zhou, Jia Li, Guolin Chi, Huirong Mitochondria-Targeted Fluorescent Nanoparticles with Large Stokes Shift for Long-Term BioImaging |
title | Mitochondria-Targeted Fluorescent Nanoparticles with Large Stokes Shift for Long-Term BioImaging |
title_full | Mitochondria-Targeted Fluorescent Nanoparticles with Large Stokes Shift for Long-Term BioImaging |
title_fullStr | Mitochondria-Targeted Fluorescent Nanoparticles with Large Stokes Shift for Long-Term BioImaging |
title_full_unstemmed | Mitochondria-Targeted Fluorescent Nanoparticles with Large Stokes Shift for Long-Term BioImaging |
title_short | Mitochondria-Targeted Fluorescent Nanoparticles with Large Stokes Shift for Long-Term BioImaging |
title_sort | mitochondria-targeted fluorescent nanoparticles with large stokes shift for long-term bioimaging |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179964/ https://www.ncbi.nlm.nih.gov/pubmed/37175369 http://dx.doi.org/10.3390/molecules28093962 |
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