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Mitochondria-Targeted Fluorescent Nanoparticles with Large Stokes Shift for Long-Term BioImaging

Mitochondria (MITO) play a significant role in various physiological processes and are a key organelle associated with different human diseases including cancer, diabetes mellitus, atherosclerosis, Alzheimer’s disease, etc. Thus, detecting the activity of MITO in real time is becoming more and more...

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Detalles Bibliográficos
Autores principales: Li, Xiao, Zhang, Tao, Diao, Xuebo, Li, Yu, Su, Yue, Yang, Jiapei, Shang, Zibo, Liu, Shuai, Zhou, Jia, Li, Guolin, Chi, Huirong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179964/
https://www.ncbi.nlm.nih.gov/pubmed/37175369
http://dx.doi.org/10.3390/molecules28093962
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author Li, Xiao
Zhang, Tao
Diao, Xuebo
Li, Yu
Su, Yue
Yang, Jiapei
Shang, Zibo
Liu, Shuai
Zhou, Jia
Li, Guolin
Chi, Huirong
author_facet Li, Xiao
Zhang, Tao
Diao, Xuebo
Li, Yu
Su, Yue
Yang, Jiapei
Shang, Zibo
Liu, Shuai
Zhou, Jia
Li, Guolin
Chi, Huirong
author_sort Li, Xiao
collection PubMed
description Mitochondria (MITO) play a significant role in various physiological processes and are a key organelle associated with different human diseases including cancer, diabetes mellitus, atherosclerosis, Alzheimer’s disease, etc. Thus, detecting the activity of MITO in real time is becoming more and more important. Herein, a novel class of amphiphilic aggregation-induced emission (AIE) active probe fluorescence (AC-QC nanoparticles) based on a quinoxalinone scaffold was developed for imaging MITO. AC-QC nanoparticles possess an excellent ability to monitor MITO in real-time. This probe demonstrated the following advantages: (1) lower cytotoxicity; (2) superior photostability; and (3) good performance in long-term imaging in vitro. Each result of these indicates that self-assembled AC-QC nanoparticles can be used as effective and promising MITO-targeted fluorescent probes.
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spelling pubmed-101799642023-05-13 Mitochondria-Targeted Fluorescent Nanoparticles with Large Stokes Shift for Long-Term BioImaging Li, Xiao Zhang, Tao Diao, Xuebo Li, Yu Su, Yue Yang, Jiapei Shang, Zibo Liu, Shuai Zhou, Jia Li, Guolin Chi, Huirong Molecules Article Mitochondria (MITO) play a significant role in various physiological processes and are a key organelle associated with different human diseases including cancer, diabetes mellitus, atherosclerosis, Alzheimer’s disease, etc. Thus, detecting the activity of MITO in real time is becoming more and more important. Herein, a novel class of amphiphilic aggregation-induced emission (AIE) active probe fluorescence (AC-QC nanoparticles) based on a quinoxalinone scaffold was developed for imaging MITO. AC-QC nanoparticles possess an excellent ability to monitor MITO in real-time. This probe demonstrated the following advantages: (1) lower cytotoxicity; (2) superior photostability; and (3) good performance in long-term imaging in vitro. Each result of these indicates that self-assembled AC-QC nanoparticles can be used as effective and promising MITO-targeted fluorescent probes. MDPI 2023-05-08 /pmc/articles/PMC10179964/ /pubmed/37175369 http://dx.doi.org/10.3390/molecules28093962 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Xiao
Zhang, Tao
Diao, Xuebo
Li, Yu
Su, Yue
Yang, Jiapei
Shang, Zibo
Liu, Shuai
Zhou, Jia
Li, Guolin
Chi, Huirong
Mitochondria-Targeted Fluorescent Nanoparticles with Large Stokes Shift for Long-Term BioImaging
title Mitochondria-Targeted Fluorescent Nanoparticles with Large Stokes Shift for Long-Term BioImaging
title_full Mitochondria-Targeted Fluorescent Nanoparticles with Large Stokes Shift for Long-Term BioImaging
title_fullStr Mitochondria-Targeted Fluorescent Nanoparticles with Large Stokes Shift for Long-Term BioImaging
title_full_unstemmed Mitochondria-Targeted Fluorescent Nanoparticles with Large Stokes Shift for Long-Term BioImaging
title_short Mitochondria-Targeted Fluorescent Nanoparticles with Large Stokes Shift for Long-Term BioImaging
title_sort mitochondria-targeted fluorescent nanoparticles with large stokes shift for long-term bioimaging
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179964/
https://www.ncbi.nlm.nih.gov/pubmed/37175369
http://dx.doi.org/10.3390/molecules28093962
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