Cargando…

Computational Analysis of Histamine Protonation Effects on H(1)R Binding

Despite numerous studies investigating histamine and its receptors, the impact of histamine protonation states on binding to the histamine H [Formula: see text]-receptor (H [Formula: see text] R) has remained elusive. Therefore, we assessed the influence of different histamine tautomers ([Formula: s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Conrad, Marcus, Horn, Anselm H. C., Sticht, Heinrich
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180022/ https://www.ncbi.nlm.nih.gov/pubmed/37175183 http://dx.doi.org/10.3390/molecules28093774

Ejemplares similares

Effect of Ions and Sequence Variants on the Antagonist Binding Properties of the Histamine H(1) Receptor
por: Conrad, Marcus, et al.
Publicado: (2022)

Agonist Binding and G Protein Coupling in Histamine H(2) Receptor: A Molecular Dynamics Study
por: Conrad, Marcus, et al.
Publicado: (2020)

Computational Characterization of the Binding Properties of the HIV1-Neutralizing Antibody PG16 and Design of PG16-Derived CDRH3 Peptides
por: Deubler, Manuel, et al.
Publicado: (2023)

A Metadynamics-Based Protocol for the Determination of GPCR-Ligand Binding Modes
por: Söldner, Christian A., et al.
Publicado: (2019)

Conformational Stability of Fibrillar Amyloid-Beta Oligomers via Protofilament Pair Formation – A Systematic Computational Study
por: Kahler, Anna, et al.
Publicado: (2013)

Is there a sodium effect in fibrillar amyloid-β oligomers?
por: Horn, Anselm HC, et al.
Publicado: (2014)

Synthetic Protein Scaffolds Based on Peptide Motifs and Cognate Adaptor Domains for Improving Metabolic Productivity
por: Horn, Anselm H. C., et al.
Publicado: (2015)

Specific Engineered G Protein Coupling to Histamine Receptors Revealed from Cellular Assay Experiments and Accelerated Molecular Dynamics Simulations
por: Höring, Carina, et al.
Publicado: (2021)

Stability of single and double layer fibrillar amyloid-β oligomers
por: Kahler, Anna, et al.
Publicado: (2013)

Is the novel amyloid-β tetramer fold a stable conformation?
por: Socher, Eileen, et al.
Publicado: (2013)

Interaction of Glycolipids with the Macrophage Surface Receptor Mincle – a Systematic Molecular Dynamics Study
por: Söldner, Christian A., et al.
Publicado: (2018)

Role of the N-terminus for the stability of an amyloid-β fibril with three-fold symmetry
por: Söldner, Christian A., et al.
Publicado: (2017)

Histamine and H(1)-histamine receptors faster venous circulation
por: Galajda, Zoltan, et al.
Publicado: (2011)

Exploring the Effect of Cyclization of Histamine H(1) Receptor Antagonists on Ligand Binding Kinetics
por: Wang, Zhiyong, et al.
Publicado: (2021)

Selection and Characterization of Tau Binding ᴅ-Enantiomeric Peptides with Potential for Therapy of Alzheimer Disease
por: Dammers, Christina, et al.
Publicado: (2016)

Histamine binding activity of surface-modified yeast by histamine binding protein (HBP)
por: Jang, Hyeweon, et al.
Publicado: (2021)

Molecular Determinants of the Kinetic Binding Properties of Antihistamines at the Histamine H(1) Receptors
por: Akimoto, Hayato, et al.
Publicado: (2021)

Mutations in the B.1.1.7 SARS-CoV-2 Spike Protein Reduce Receptor-Binding Affinity and Induce a Flexible Link to the Fusion Peptide
por: Socher, Eileen, et al.
Publicado: (2021)

The Effect of Deuteration on the H(2) Receptor Histamine Binding Profile: A Computational Insight into Modified Hydrogen Bonding Interactions
por: Hok, Lucija, et al.
Publicado: (2020)

Signaling Pathway of Histamine H(1) Receptor-Mediated Histamine H(1) Receptor Gene Upregulation Induced by Histamine in U-373 MG Cells
por: Mizuguchi, Hiroyuki, et al.
Publicado: (2021)

Effects of Olopatadine Hydrochloride, a Histamine H(1) Receptor Antagonist, on Histamine-Induced Skin Responses
por: Hashimoto, Takashi, et al.
Publicado: (2010)

Probing the potential of CnaB-type domains for the design of tag/catcher systems
por: Pröschel, Marlene, et al.
Publicado: (2017)

Association of proton pump inhibitor and histamine H(2)-receptor antagonists with restless legs syndrome
por: Earley, Eric J, et al.
Publicado: (2020)

DNA binding by Corynebacterium glutamicum TetR-type transcription regulator AmtR
por: Muhl, Daniela, et al.
Publicado: (2009)

Research Advances and Prospects on Mechanism of Sinomenin on Histamine Release and the Binding to Histamine Receptors
por: Zhang, Yu-Shi, et al.
Publicado: (2018)

Histamine and Histamine H4 Receptor Promotes Osteoclastogenesis in Rheumatoid Arthritis
por: Kim, Kyoung-Woon, et al.
Publicado: (2017)

Histamine and histamine receptor H1 (HRH1) axis: new target for enhancing immunotherapy response
por: Bai, Ziyi, et al.
Publicado: (2022)

Comparison and Analysis of Delirium Induced by Histamine H(2) Receptor Antagonists and Proton Pump Inhibitors in Cancer Patients
por: Fujii, Shiro, et al.
Publicado: (2012)

Challenges for the implementation of next generation sequencing-based expanded carrier screening: Lessons learned from the ciliopathies
por: Vintschger, Ella, et al.
Publicado: (2022)

Decrease in tumour growth by injections of histamine or serotonin in fibrosarcoma-bearing mice: influence of H1 and H2 histamine receptors.
por: Burtin, C., et al.
Publicado: (1982)

Effect of H(1)- and H(2)-histamine receptor blockade on postexercise insulin sensitivity
por: Pellinger, Thomas K, et al.
Publicado: (2013)

Structural insights into the agonists binding and receptor selectivity of human histamine H(4) receptor
por: Im, Dohyun, et al.
Publicado: (2023)

Specific histamine regulating activity of surface‐modified yeast vacuoles by histamine‐ binding protein and its immune‐enhancing effect
por: Jang, Hyeweon, et al.
Publicado: (2022)

Histamine H3 receptors aggravate cerebral ischaemic injury by histamine-independent mechanisms
por: Yan, Haijing, et al.
Publicado: (2014)

Cardiovascular effects of H(3) histamine receptor inverse agonist/ H(4) histamine receptor agonist, clobenpropit, in hemorrhage-shocked rats
por: Wanot, Bartosz, et al.
Publicado: (2018)

Histamine Activates Human Eosinophils via H(2)R and H(4)R Predominantly in Atopic Dermatitis Patients
por: Beyer, Leonie, et al.
Publicado: (2022)

Mimicking titration experiments with MD simulations: A protocol for the investigation of pH-dependent effects on proteins
por: Socher, Eileen, et al.
Publicado: (2016)

Development of novel fluorescent histamine H(1)-receptor antagonists to study ligand-binding kinetics in living cells
por: Stoddart, Leigh A., et al.
Publicado: (2018)

Differential Regulation of Thermodynamic Binding Forces of Levocetirizine and (S)-Cetirizine by Lys191 in Human Histamine H(1) Receptors
por: Hishinuma, Shigeru, et al.
Publicado: (2018)

Erratum: Mimicking titration experiments with MD simulations: A protocol for the investigation of pH-dependent effects on proteins
por: Socher, Eileen, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_j8ou92qrnev4dgg7i1dnr69pga