Identification of Small Molecule Inhibitors of Human Cytomegalovirus pUL89 Endonuclease Using Integrated Computational Approaches

Replication of Human Cytomegalovirus (HCMV) requires the presence of a metal-dependent endonuclease at the C-terminus of pUL89, in order to properly pack and cleave the viral genome. Therefore, pUL89 is an attractive target to design anti-CMV intervention. Herein, we used integrated structure-based...

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Detalles Bibliográficos
Autores principales: Almehmadi, Mazen, Haq, Ihtisham Ul, Alsaiari, Ahad Amer, Alshabrmi, Fahad M., Abdulaziz, Osama, Allahyani, Mamdouh, Aladhadh, Mohammed, Shafie, Alaa, Aljuaid, Abdulelah, Alotaibi, Rema Turki, Ullah, Jawad, Alharthi, Nada Saud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180037/
https://www.ncbi.nlm.nih.gov/pubmed/37175348
http://dx.doi.org/10.3390/molecules28093938

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180037/
https://www.ncbi.nlm.nih.gov/pubmed/37175348
http://dx.doi.org/10.3390/molecules28093938

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