Design, Synthesis and Biological Evaluation of Novel Pleuromutilin Derivatives Containing 6-Chloro-1-R-1H-pyrazolo[3,4-d]pyrimidine-4-amino Side Chain

Two series of pleuromutilin derivatives were designed and synthesized as inhibitors against Staphylococcus aureus (S. aureus). 6-chloro-4-amino-1-R-1H-pyrazolo[3,4-d]pyrimidine or 4-(6-chloro-1-R-1H-pyrazolo[3,4-d]pyrimidine-4-yl)amino-phenylthiol were connected to pleuromutilin. A diverse array of...

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Detalles Bibliográficos
Autores principales: Wang, Jun, Hu, Yu-Han, Zhou, Ke-Xin, Wang, Wei, Li, Fei, Li, Ke, Zhang, Guang-Yu, Tang, You-Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180054/
https://www.ncbi.nlm.nih.gov/pubmed/37175382
http://dx.doi.org/10.3390/molecules28093975

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180054/
https://www.ncbi.nlm.nih.gov/pubmed/37175382
http://dx.doi.org/10.3390/molecules28093975

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