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The Role of MMP-9 and MMP-9 Inhibition in Different Types of Thyroid Carcinoma

Matrix metalloproteinase-9 (MMP-9), one of the most investigated and studied biomarkers of the MMPs family, is a zinc-dependent proteolytic metalloenzyme whose primary function is degrading the extracellular matrix (ECM). It has been proved that MMP-9 expression elevates in multiple pathological con...

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Autores principales: Li, Zhenshengnan, Wei, Jia, Chen, Bowen, Wang, Yaoqi, Yang, Shuai, Wu, Kehui, Meng, Xianying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180081/
https://www.ncbi.nlm.nih.gov/pubmed/37175113
http://dx.doi.org/10.3390/molecules28093705
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author Li, Zhenshengnan
Wei, Jia
Chen, Bowen
Wang, Yaoqi
Yang, Shuai
Wu, Kehui
Meng, Xianying
author_facet Li, Zhenshengnan
Wei, Jia
Chen, Bowen
Wang, Yaoqi
Yang, Shuai
Wu, Kehui
Meng, Xianying
author_sort Li, Zhenshengnan
collection PubMed
description Matrix metalloproteinase-9 (MMP-9), one of the most investigated and studied biomarkers of the MMPs family, is a zinc-dependent proteolytic metalloenzyme whose primary function is degrading the extracellular matrix (ECM). It has been proved that MMP-9 expression elevates in multiple pathological conditions, including thyroid carcinoma. MMP-9 has a detectable higher level in malignant or metastatic thyroid tumor tissues than in normal or benign tissues and acts as an additional marker to distinguish different tumor stages because of its close correlations with clinical features, such as lymph node metastasis, TNM stage, tumor size and so on. Natural and non-natural MMP-9 inhibitors suppress its expression, block the progression of diseases, and play a role in therapy consequently. MMP-9 inhibitory molecules also assist in treating thyroid tumors by suppressing the proliferation, invasion, migration, metastasis, viability, adhesion, motility, epithelial-mesenchymal transition (EMT), and other risk factors of different thyroid cancer cells. In a word, discovering and designing MMP-9 inhibitors provide great therapeutic effects and promising clinical values in various types of thyroid carcinoma.
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spelling pubmed-101800812023-05-13 The Role of MMP-9 and MMP-9 Inhibition in Different Types of Thyroid Carcinoma Li, Zhenshengnan Wei, Jia Chen, Bowen Wang, Yaoqi Yang, Shuai Wu, Kehui Meng, Xianying Molecules Review Matrix metalloproteinase-9 (MMP-9), one of the most investigated and studied biomarkers of the MMPs family, is a zinc-dependent proteolytic metalloenzyme whose primary function is degrading the extracellular matrix (ECM). It has been proved that MMP-9 expression elevates in multiple pathological conditions, including thyroid carcinoma. MMP-9 has a detectable higher level in malignant or metastatic thyroid tumor tissues than in normal or benign tissues and acts as an additional marker to distinguish different tumor stages because of its close correlations with clinical features, such as lymph node metastasis, TNM stage, tumor size and so on. Natural and non-natural MMP-9 inhibitors suppress its expression, block the progression of diseases, and play a role in therapy consequently. MMP-9 inhibitory molecules also assist in treating thyroid tumors by suppressing the proliferation, invasion, migration, metastasis, viability, adhesion, motility, epithelial-mesenchymal transition (EMT), and other risk factors of different thyroid cancer cells. In a word, discovering and designing MMP-9 inhibitors provide great therapeutic effects and promising clinical values in various types of thyroid carcinoma. MDPI 2023-04-25 /pmc/articles/PMC10180081/ /pubmed/37175113 http://dx.doi.org/10.3390/molecules28093705 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Li, Zhenshengnan
Wei, Jia
Chen, Bowen
Wang, Yaoqi
Yang, Shuai
Wu, Kehui
Meng, Xianying
The Role of MMP-9 and MMP-9 Inhibition in Different Types of Thyroid Carcinoma
title The Role of MMP-9 and MMP-9 Inhibition in Different Types of Thyroid Carcinoma
title_full The Role of MMP-9 and MMP-9 Inhibition in Different Types of Thyroid Carcinoma
title_fullStr The Role of MMP-9 and MMP-9 Inhibition in Different Types of Thyroid Carcinoma
title_full_unstemmed The Role of MMP-9 and MMP-9 Inhibition in Different Types of Thyroid Carcinoma
title_short The Role of MMP-9 and MMP-9 Inhibition in Different Types of Thyroid Carcinoma
title_sort role of mmp-9 and mmp-9 inhibition in different types of thyroid carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180081/
https://www.ncbi.nlm.nih.gov/pubmed/37175113
http://dx.doi.org/10.3390/molecules28093705
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