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Dipsacus and Scabiosa Species—The Source of Specialized Metabolites with High Biological Relevance: A Review
The genera Dipsacus L. and Scabiosa L. of the Caprifoliaceae family are widely distributed in Europe, Asia, and Africa. This work reviews the available literature on the phytochemical profiles, ethnomedicinal uses, and biological activities of the most popular species. These plants are rich sources...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180103/ https://www.ncbi.nlm.nih.gov/pubmed/37175164 http://dx.doi.org/10.3390/molecules28093754 |
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author | Skała, Ewa Szopa, Agnieszka |
author_facet | Skała, Ewa Szopa, Agnieszka |
author_sort | Skała, Ewa |
collection | PubMed |
description | The genera Dipsacus L. and Scabiosa L. of the Caprifoliaceae family are widely distributed in Europe, Asia, and Africa. This work reviews the available literature on the phytochemical profiles, ethnomedicinal uses, and biological activities of the most popular species. These plants are rich sources of many valuable specialized metabolites with beneficial medicinal properties, such as triterpenoid derivatives, iridoids, phenolic acids, and flavonoids. They are also sources of essential oils. The genus Dipsacus has been used for centuries in Chinese and Korean folk medicines to treat bone (osteoporosis) and joint problems (rheumatic arthritis). The Korean Herbal Pharmacopoeia and Chinese Pharmacopoeia include Dipsaci radix, the dried roots of D. asperoides C.Y.Cheng & T.M.Ai. In addition, S. comosa Fisch. ex Roem & Schult. and S. tschiliiensis Grunning are used in traditional Mongolian medicine to treat liver diseases. The current scientific literature data indicate that these plants and their constituents have various biological properties, including inter alia antiarthritic, anti-neurodegenerative, anti-inflammatory, antioxidant, anticancer, and antimicrobial activities; they have also been found to strengthen tendon and bone tissue and protect the liver, heart, and kidney. The essential oils possess antibacterial, antifungal, and insecticidal properties. This paper reviews the key biological values of Dipsacus and Scabiosa species, as identified by in vitro and in vivo studies, and presents their potential pharmacological applications. |
format | Online Article Text |
id | pubmed-10180103 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101801032023-05-13 Dipsacus and Scabiosa Species—The Source of Specialized Metabolites with High Biological Relevance: A Review Skała, Ewa Szopa, Agnieszka Molecules Review The genera Dipsacus L. and Scabiosa L. of the Caprifoliaceae family are widely distributed in Europe, Asia, and Africa. This work reviews the available literature on the phytochemical profiles, ethnomedicinal uses, and biological activities of the most popular species. These plants are rich sources of many valuable specialized metabolites with beneficial medicinal properties, such as triterpenoid derivatives, iridoids, phenolic acids, and flavonoids. They are also sources of essential oils. The genus Dipsacus has been used for centuries in Chinese and Korean folk medicines to treat bone (osteoporosis) and joint problems (rheumatic arthritis). The Korean Herbal Pharmacopoeia and Chinese Pharmacopoeia include Dipsaci radix, the dried roots of D. asperoides C.Y.Cheng & T.M.Ai. In addition, S. comosa Fisch. ex Roem & Schult. and S. tschiliiensis Grunning are used in traditional Mongolian medicine to treat liver diseases. The current scientific literature data indicate that these plants and their constituents have various biological properties, including inter alia antiarthritic, anti-neurodegenerative, anti-inflammatory, antioxidant, anticancer, and antimicrobial activities; they have also been found to strengthen tendon and bone tissue and protect the liver, heart, and kidney. The essential oils possess antibacterial, antifungal, and insecticidal properties. This paper reviews the key biological values of Dipsacus and Scabiosa species, as identified by in vitro and in vivo studies, and presents their potential pharmacological applications. MDPI 2023-04-27 /pmc/articles/PMC10180103/ /pubmed/37175164 http://dx.doi.org/10.3390/molecules28093754 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Skała, Ewa Szopa, Agnieszka Dipsacus and Scabiosa Species—The Source of Specialized Metabolites with High Biological Relevance: A Review |
title | Dipsacus and Scabiosa Species—The Source of Specialized Metabolites with High Biological Relevance: A Review |
title_full | Dipsacus and Scabiosa Species—The Source of Specialized Metabolites with High Biological Relevance: A Review |
title_fullStr | Dipsacus and Scabiosa Species—The Source of Specialized Metabolites with High Biological Relevance: A Review |
title_full_unstemmed | Dipsacus and Scabiosa Species—The Source of Specialized Metabolites with High Biological Relevance: A Review |
title_short | Dipsacus and Scabiosa Species—The Source of Specialized Metabolites with High Biological Relevance: A Review |
title_sort | dipsacus and scabiosa species—the source of specialized metabolites with high biological relevance: a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180103/ https://www.ncbi.nlm.nih.gov/pubmed/37175164 http://dx.doi.org/10.3390/molecules28093754 |
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