Palladium-Catalyzed Synthesis of Cyclopropylthiophenes and Their Derivatization

The cyclopropylthiophene moiety has attracted the attention of the scientific community for its potential pharmaceutical applications. However, synthesis of the compounds containing this framework remains challenging, has rarely been reported and remains unresolved. Here we provide optimized synthes...

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Autores principales: Paškevičius, Tomas, Lapinskaitė, Ringailė, Stončius, Sigitas, Sadzevičienė, Rita, Judžentienė, Asta, Labanauskas, Linas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180236/
https://www.ncbi.nlm.nih.gov/pubmed/37175178
http://dx.doi.org/10.3390/molecules28093770
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author Paškevičius, Tomas
Lapinskaitė, Ringailė
Stončius, Sigitas
Sadzevičienė, Rita
Judžentienė, Asta
Labanauskas, Linas
author_facet Paškevičius, Tomas
Lapinskaitė, Ringailė
Stončius, Sigitas
Sadzevičienė, Rita
Judžentienė, Asta
Labanauskas, Linas
author_sort Paškevičius, Tomas
collection PubMed
description The cyclopropylthiophene moiety has attracted the attention of the scientific community for its potential pharmaceutical applications. However, synthesis of the compounds containing this framework remains challenging, has rarely been reported and remains unresolved. Here we provide optimized syntheses for cyclopropylthiophenes and their derivatives, containing carbonyl, acetyl, carboxylic acid, methyl carboxylate, nitrile, bromide and sulfonyl chloride moieties.
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spelling pubmed-101802362023-05-13 Palladium-Catalyzed Synthesis of Cyclopropylthiophenes and Their Derivatization Paškevičius, Tomas Lapinskaitė, Ringailė Stončius, Sigitas Sadzevičienė, Rita Judžentienė, Asta Labanauskas, Linas Molecules Communication The cyclopropylthiophene moiety has attracted the attention of the scientific community for its potential pharmaceutical applications. However, synthesis of the compounds containing this framework remains challenging, has rarely been reported and remains unresolved. Here we provide optimized syntheses for cyclopropylthiophenes and their derivatives, containing carbonyl, acetyl, carboxylic acid, methyl carboxylate, nitrile, bromide and sulfonyl chloride moieties. MDPI 2023-04-27 /pmc/articles/PMC10180236/ /pubmed/37175178 http://dx.doi.org/10.3390/molecules28093770 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Paškevičius, Tomas
Lapinskaitė, Ringailė
Stončius, Sigitas
Sadzevičienė, Rita
Judžentienė, Asta
Labanauskas, Linas
Palladium-Catalyzed Synthesis of Cyclopropylthiophenes and Their Derivatization
title Palladium-Catalyzed Synthesis of Cyclopropylthiophenes and Their Derivatization
title_full Palladium-Catalyzed Synthesis of Cyclopropylthiophenes and Their Derivatization
title_fullStr Palladium-Catalyzed Synthesis of Cyclopropylthiophenes and Their Derivatization
title_full_unstemmed Palladium-Catalyzed Synthesis of Cyclopropylthiophenes and Their Derivatization
title_short Palladium-Catalyzed Synthesis of Cyclopropylthiophenes and Their Derivatization
title_sort palladium-catalyzed synthesis of cyclopropylthiophenes and their derivatization
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180236/
https://www.ncbi.nlm.nih.gov/pubmed/37175178
http://dx.doi.org/10.3390/molecules28093770
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