Cargando…

Long-Term Antibacterial Efficacy of Cetylpyridinium Chloride-Montmorillonite Containing PMMA Resin Cement

Despite being able to adhesively restore teeth, adhesives and cement do not possess any anticariogenic protection potential, by which caries recurrence may still occur and reduce the clinical lifetime of adhesive restorations. Several antibacterial agents have been incorporated into dental adhesives...

Descripción completa

Detalles Bibliográficos
Autores principales: Yoshihara, Kumiko, Nagaoka, Noriyuki, Makita, Yoji, Yoshida, Yasuhiro, Van Meerbeek, Bart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180279/
https://www.ncbi.nlm.nih.gov/pubmed/37177041
http://dx.doi.org/10.3390/nano13091495
_version_ 1785041298870239232
author Yoshihara, Kumiko
Nagaoka, Noriyuki
Makita, Yoji
Yoshida, Yasuhiro
Van Meerbeek, Bart
author_facet Yoshihara, Kumiko
Nagaoka, Noriyuki
Makita, Yoji
Yoshida, Yasuhiro
Van Meerbeek, Bart
author_sort Yoshihara, Kumiko
collection PubMed
description Despite being able to adhesively restore teeth, adhesives and cement do not possess any anticariogenic protection potential, by which caries recurrence may still occur and reduce the clinical lifetime of adhesive restorations. Several antibacterial agents have been incorporated into dental adhesives and cement to render them anticariogenic. Due to an additional therapeutic effect, such materials are classified as ‘dental combination products’ with more strict market regulations. We incorporated cetylpyridinium chloride (CPC), often used for oral hygiene applications, into montmorillonite (CPC-Mont), the latter to serve as a carrier for controlled CPC release. CPC-Mont incorporated into tissue conditioner has been approved by the Pharmaceuticals and Medical Devices Agency (PmontMDA) in Japan. To produce a clinically effective dental cement with the antibacterial potential to prevent secondary caries, we incorporated CPC-Mont into PMMA resin cement. We measured the flexural strength, shear bond strength onto dentin, CPC release, and the biofilm-inhibition potential of the experimental CPC-Mont-containing PMMA cement. An 8 and 10 wt% CPC-Mont concentration revealed the antibacterial potential without reducing the mechanical properties of the PMMA cement.
format Online
Article
Text
id pubmed-10180279
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-101802792023-05-13 Long-Term Antibacterial Efficacy of Cetylpyridinium Chloride-Montmorillonite Containing PMMA Resin Cement Yoshihara, Kumiko Nagaoka, Noriyuki Makita, Yoji Yoshida, Yasuhiro Van Meerbeek, Bart Nanomaterials (Basel) Article Despite being able to adhesively restore teeth, adhesives and cement do not possess any anticariogenic protection potential, by which caries recurrence may still occur and reduce the clinical lifetime of adhesive restorations. Several antibacterial agents have been incorporated into dental adhesives and cement to render them anticariogenic. Due to an additional therapeutic effect, such materials are classified as ‘dental combination products’ with more strict market regulations. We incorporated cetylpyridinium chloride (CPC), often used for oral hygiene applications, into montmorillonite (CPC-Mont), the latter to serve as a carrier for controlled CPC release. CPC-Mont incorporated into tissue conditioner has been approved by the Pharmaceuticals and Medical Devices Agency (PmontMDA) in Japan. To produce a clinically effective dental cement with the antibacterial potential to prevent secondary caries, we incorporated CPC-Mont into PMMA resin cement. We measured the flexural strength, shear bond strength onto dentin, CPC release, and the biofilm-inhibition potential of the experimental CPC-Mont-containing PMMA cement. An 8 and 10 wt% CPC-Mont concentration revealed the antibacterial potential without reducing the mechanical properties of the PMMA cement. MDPI 2023-04-27 /pmc/articles/PMC10180279/ /pubmed/37177041 http://dx.doi.org/10.3390/nano13091495 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yoshihara, Kumiko
Nagaoka, Noriyuki
Makita, Yoji
Yoshida, Yasuhiro
Van Meerbeek, Bart
Long-Term Antibacterial Efficacy of Cetylpyridinium Chloride-Montmorillonite Containing PMMA Resin Cement
title Long-Term Antibacterial Efficacy of Cetylpyridinium Chloride-Montmorillonite Containing PMMA Resin Cement
title_full Long-Term Antibacterial Efficacy of Cetylpyridinium Chloride-Montmorillonite Containing PMMA Resin Cement
title_fullStr Long-Term Antibacterial Efficacy of Cetylpyridinium Chloride-Montmorillonite Containing PMMA Resin Cement
title_full_unstemmed Long-Term Antibacterial Efficacy of Cetylpyridinium Chloride-Montmorillonite Containing PMMA Resin Cement
title_short Long-Term Antibacterial Efficacy of Cetylpyridinium Chloride-Montmorillonite Containing PMMA Resin Cement
title_sort long-term antibacterial efficacy of cetylpyridinium chloride-montmorillonite containing pmma resin cement
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180279/
https://www.ncbi.nlm.nih.gov/pubmed/37177041
http://dx.doi.org/10.3390/nano13091495
work_keys_str_mv AT yoshiharakumiko longtermantibacterialefficacyofcetylpyridiniumchloridemontmorillonitecontainingpmmaresincement
AT nagaokanoriyuki longtermantibacterialefficacyofcetylpyridiniumchloridemontmorillonitecontainingpmmaresincement
AT makitayoji longtermantibacterialefficacyofcetylpyridiniumchloridemontmorillonitecontainingpmmaresincement
AT yoshidayasuhiro longtermantibacterialefficacyofcetylpyridiniumchloridemontmorillonitecontainingpmmaresincement
AT vanmeerbeekbart longtermantibacterialefficacyofcetylpyridiniumchloridemontmorillonitecontainingpmmaresincement