Synthesis, Quality Control and Preliminary Activity Evaluation of a New Compound HM475

Based on the principle of molecular splicing and theory of traditional Chinese medicine pairs, a new multi-active compound (HM475) was synthesized by connecting metformin with honokiol, and its structure was characterized, which not only reduced the toxicity of raw materials, but also maintained the...

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Autores principales: Guo, Jieqing, Xie, Luming, Zhang, Jing, Cao, Han, Wang, Juanxia, Wu, Xia, Feng, Yifan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180444/
https://www.ncbi.nlm.nih.gov/pubmed/37175163
http://dx.doi.org/10.3390/molecules28093753
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author Guo, Jieqing
Xie, Luming
Zhang, Jing
Cao, Han
Wang, Juanxia
Wu, Xia
Feng, Yifan
author_facet Guo, Jieqing
Xie, Luming
Zhang, Jing
Cao, Han
Wang, Juanxia
Wu, Xia
Feng, Yifan
author_sort Guo, Jieqing
collection PubMed
description Based on the principle of molecular splicing and theory of traditional Chinese medicine pairs, a new multi-active compound (HM475) was synthesized by connecting metformin with honokiol, and its structure was characterized, which not only reduced the toxicity of raw materials, but also maintained the original activity, and had a certain significance in research and innovation. At the same time, quality control and preliminary activity evaluation were carried out, and the effect of HM475 on neuroinflammation was further explored, which provided a new idea for drug development of neurodegenerative diseases.
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spelling pubmed-101804442023-05-13 Synthesis, Quality Control and Preliminary Activity Evaluation of a New Compound HM475 Guo, Jieqing Xie, Luming Zhang, Jing Cao, Han Wang, Juanxia Wu, Xia Feng, Yifan Molecules Article Based on the principle of molecular splicing and theory of traditional Chinese medicine pairs, a new multi-active compound (HM475) was synthesized by connecting metformin with honokiol, and its structure was characterized, which not only reduced the toxicity of raw materials, but also maintained the original activity, and had a certain significance in research and innovation. At the same time, quality control and preliminary activity evaluation were carried out, and the effect of HM475 on neuroinflammation was further explored, which provided a new idea for drug development of neurodegenerative diseases. MDPI 2023-04-27 /pmc/articles/PMC10180444/ /pubmed/37175163 http://dx.doi.org/10.3390/molecules28093753 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Guo, Jieqing
Xie, Luming
Zhang, Jing
Cao, Han
Wang, Juanxia
Wu, Xia
Feng, Yifan
Synthesis, Quality Control and Preliminary Activity Evaluation of a New Compound HM475
title Synthesis, Quality Control and Preliminary Activity Evaluation of a New Compound HM475
title_full Synthesis, Quality Control and Preliminary Activity Evaluation of a New Compound HM475
title_fullStr Synthesis, Quality Control and Preliminary Activity Evaluation of a New Compound HM475
title_full_unstemmed Synthesis, Quality Control and Preliminary Activity Evaluation of a New Compound HM475
title_short Synthesis, Quality Control and Preliminary Activity Evaluation of a New Compound HM475
title_sort synthesis, quality control and preliminary activity evaluation of a new compound hm475
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180444/
https://www.ncbi.nlm.nih.gov/pubmed/37175163
http://dx.doi.org/10.3390/molecules28093753
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