Cargando…
Association of Serum Albumin Levels and Long-Term Prognosis in Patients with Biopsy-Confirmed Nonalcoholic Fatty Liver Disease
The relationship between baseline serum albumin level and long-term prognosis of patients with nonalcoholic fatty liver disease (NAFLD) remains unknown. This is a sub-analysis of the CLIONE (Clinical Outcome Nonalcoholic Fatty Liver Disease) study. The main outcomes were: death or orthotopic liver t...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180563/ https://www.ncbi.nlm.nih.gov/pubmed/37432160 http://dx.doi.org/10.3390/nu15092014 |
_version_ | 1785041364537311232 |
---|---|
author | Takahashi, Hirokazu Kawanaka, Miwa Fujii, Hideki Iwaki, Michihiro Hayashi, Hideki Toyoda, Hidenori Oeda, Satoshi Hyogo, Hideyuki Morishita, Asahiro Munekage, Kensuke Kawata, Kazuhito Tsutsumi, Tsubasa Sawada, Koji Maeshiro, Tatsuji Tobita, Hiroshi Yoshida, Yuichi Naito, Masafumi Araki, Asuka Arakaki, Shingo Kawaguchi, Takumi Noritake, Hidenao Ono, Masafumi Masaki, Tsutomu Yasuda, Satoshi Tomita, Eiichi Yoneda, Masato Tokushige, Akihiro Kamada, Yoshihiro Ueda, Shinichiro Aishima, Shinichi Sumida, Yoshio Nakajima, Atsushi Okanoue, Takeshi |
author_facet | Takahashi, Hirokazu Kawanaka, Miwa Fujii, Hideki Iwaki, Michihiro Hayashi, Hideki Toyoda, Hidenori Oeda, Satoshi Hyogo, Hideyuki Morishita, Asahiro Munekage, Kensuke Kawata, Kazuhito Tsutsumi, Tsubasa Sawada, Koji Maeshiro, Tatsuji Tobita, Hiroshi Yoshida, Yuichi Naito, Masafumi Araki, Asuka Arakaki, Shingo Kawaguchi, Takumi Noritake, Hidenao Ono, Masafumi Masaki, Tsutomu Yasuda, Satoshi Tomita, Eiichi Yoneda, Masato Tokushige, Akihiro Kamada, Yoshihiro Ueda, Shinichiro Aishima, Shinichi Sumida, Yoshio Nakajima, Atsushi Okanoue, Takeshi |
author_sort | Takahashi, Hirokazu |
collection | PubMed |
description | The relationship between baseline serum albumin level and long-term prognosis of patients with nonalcoholic fatty liver disease (NAFLD) remains unknown. This is a sub-analysis of the CLIONE (Clinical Outcome Nonalcoholic Fatty Liver Disease) study. The main outcomes were: death or orthotopic liver transplantation (OLT), liver-related death, and liver-related events (hepatocellular carcinoma [HCC], decompensated cirrhosis, and gastroesophageal varices/bleeding). 1383 Japanese patients with biopsy-confirmed NAFLD were analyzed. They were divided into 3 groups based on serum albumin: high (>4.0 g/dL), intermediate (3.5–4.0 g/dL), and low (<3.5 g/dL). Unadjusted hazard ratio [HR] of the intermediate albumin group, compared with the high albumin group, were 3.6 for death or OLT, 11.2 for liver-related death, 4.6 for HCC, 8.2 for decompensated cirrhosis, and 6.2 for gastroesophageal varices (all risks were statistically significant). After adjusting confounding factors, albumin remained significantly associated with death or OLT (intermediate vs. high albumin group: HR 3.06, 95% confidence interval [CI] 1.59–5.91, p < 0.001; low vs. high albumin group: HR 22.9, 95% CI 8.21–63.9, p < 0.001). Among biopsy-confirmed NAFLD patients, those with intermediate or low serum albumin had a significantly higher risk of death or OLT than those with high serum albumin. |
format | Online Article Text |
id | pubmed-10180563 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101805632023-05-13 Association of Serum Albumin Levels and Long-Term Prognosis in Patients with Biopsy-Confirmed Nonalcoholic Fatty Liver Disease Takahashi, Hirokazu Kawanaka, Miwa Fujii, Hideki Iwaki, Michihiro Hayashi, Hideki Toyoda, Hidenori Oeda, Satoshi Hyogo, Hideyuki Morishita, Asahiro Munekage, Kensuke Kawata, Kazuhito Tsutsumi, Tsubasa Sawada, Koji Maeshiro, Tatsuji Tobita, Hiroshi Yoshida, Yuichi Naito, Masafumi Araki, Asuka Arakaki, Shingo Kawaguchi, Takumi Noritake, Hidenao Ono, Masafumi Masaki, Tsutomu Yasuda, Satoshi Tomita, Eiichi Yoneda, Masato Tokushige, Akihiro Kamada, Yoshihiro Ueda, Shinichiro Aishima, Shinichi Sumida, Yoshio Nakajima, Atsushi Okanoue, Takeshi Nutrients Article The relationship between baseline serum albumin level and long-term prognosis of patients with nonalcoholic fatty liver disease (NAFLD) remains unknown. This is a sub-analysis of the CLIONE (Clinical Outcome Nonalcoholic Fatty Liver Disease) study. The main outcomes were: death or orthotopic liver transplantation (OLT), liver-related death, and liver-related events (hepatocellular carcinoma [HCC], decompensated cirrhosis, and gastroesophageal varices/bleeding). 1383 Japanese patients with biopsy-confirmed NAFLD were analyzed. They were divided into 3 groups based on serum albumin: high (>4.0 g/dL), intermediate (3.5–4.0 g/dL), and low (<3.5 g/dL). Unadjusted hazard ratio [HR] of the intermediate albumin group, compared with the high albumin group, were 3.6 for death or OLT, 11.2 for liver-related death, 4.6 for HCC, 8.2 for decompensated cirrhosis, and 6.2 for gastroesophageal varices (all risks were statistically significant). After adjusting confounding factors, albumin remained significantly associated with death or OLT (intermediate vs. high albumin group: HR 3.06, 95% confidence interval [CI] 1.59–5.91, p < 0.001; low vs. high albumin group: HR 22.9, 95% CI 8.21–63.9, p < 0.001). Among biopsy-confirmed NAFLD patients, those with intermediate or low serum albumin had a significantly higher risk of death or OLT than those with high serum albumin. MDPI 2023-04-22 /pmc/articles/PMC10180563/ /pubmed/37432160 http://dx.doi.org/10.3390/nu15092014 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Takahashi, Hirokazu Kawanaka, Miwa Fujii, Hideki Iwaki, Michihiro Hayashi, Hideki Toyoda, Hidenori Oeda, Satoshi Hyogo, Hideyuki Morishita, Asahiro Munekage, Kensuke Kawata, Kazuhito Tsutsumi, Tsubasa Sawada, Koji Maeshiro, Tatsuji Tobita, Hiroshi Yoshida, Yuichi Naito, Masafumi Araki, Asuka Arakaki, Shingo Kawaguchi, Takumi Noritake, Hidenao Ono, Masafumi Masaki, Tsutomu Yasuda, Satoshi Tomita, Eiichi Yoneda, Masato Tokushige, Akihiro Kamada, Yoshihiro Ueda, Shinichiro Aishima, Shinichi Sumida, Yoshio Nakajima, Atsushi Okanoue, Takeshi Association of Serum Albumin Levels and Long-Term Prognosis in Patients with Biopsy-Confirmed Nonalcoholic Fatty Liver Disease |
title | Association of Serum Albumin Levels and Long-Term Prognosis in Patients with Biopsy-Confirmed Nonalcoholic Fatty Liver Disease |
title_full | Association of Serum Albumin Levels and Long-Term Prognosis in Patients with Biopsy-Confirmed Nonalcoholic Fatty Liver Disease |
title_fullStr | Association of Serum Albumin Levels and Long-Term Prognosis in Patients with Biopsy-Confirmed Nonalcoholic Fatty Liver Disease |
title_full_unstemmed | Association of Serum Albumin Levels and Long-Term Prognosis in Patients with Biopsy-Confirmed Nonalcoholic Fatty Liver Disease |
title_short | Association of Serum Albumin Levels and Long-Term Prognosis in Patients with Biopsy-Confirmed Nonalcoholic Fatty Liver Disease |
title_sort | association of serum albumin levels and long-term prognosis in patients with biopsy-confirmed nonalcoholic fatty liver disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180563/ https://www.ncbi.nlm.nih.gov/pubmed/37432160 http://dx.doi.org/10.3390/nu15092014 |
work_keys_str_mv | AT takahashihirokazu associationofserumalbuminlevelsandlongtermprognosisinpatientswithbiopsyconfirmednonalcoholicfattyliverdisease AT kawanakamiwa associationofserumalbuminlevelsandlongtermprognosisinpatientswithbiopsyconfirmednonalcoholicfattyliverdisease AT fujiihideki associationofserumalbuminlevelsandlongtermprognosisinpatientswithbiopsyconfirmednonalcoholicfattyliverdisease AT iwakimichihiro associationofserumalbuminlevelsandlongtermprognosisinpatientswithbiopsyconfirmednonalcoholicfattyliverdisease AT hayashihideki associationofserumalbuminlevelsandlongtermprognosisinpatientswithbiopsyconfirmednonalcoholicfattyliverdisease AT toyodahidenori associationofserumalbuminlevelsandlongtermprognosisinpatientswithbiopsyconfirmednonalcoholicfattyliverdisease AT oedasatoshi associationofserumalbuminlevelsandlongtermprognosisinpatientswithbiopsyconfirmednonalcoholicfattyliverdisease AT hyogohideyuki associationofserumalbuminlevelsandlongtermprognosisinpatientswithbiopsyconfirmednonalcoholicfattyliverdisease AT morishitaasahiro associationofserumalbuminlevelsandlongtermprognosisinpatientswithbiopsyconfirmednonalcoholicfattyliverdisease AT munekagekensuke associationofserumalbuminlevelsandlongtermprognosisinpatientswithbiopsyconfirmednonalcoholicfattyliverdisease AT kawatakazuhito associationofserumalbuminlevelsandlongtermprognosisinpatientswithbiopsyconfirmednonalcoholicfattyliverdisease AT tsutsumitsubasa associationofserumalbuminlevelsandlongtermprognosisinpatientswithbiopsyconfirmednonalcoholicfattyliverdisease AT sawadakoji associationofserumalbuminlevelsandlongtermprognosisinpatientswithbiopsyconfirmednonalcoholicfattyliverdisease AT maeshirotatsuji associationofserumalbuminlevelsandlongtermprognosisinpatientswithbiopsyconfirmednonalcoholicfattyliverdisease AT tobitahiroshi associationofserumalbuminlevelsandlongtermprognosisinpatientswithbiopsyconfirmednonalcoholicfattyliverdisease AT yoshidayuichi associationofserumalbuminlevelsandlongtermprognosisinpatientswithbiopsyconfirmednonalcoholicfattyliverdisease AT naitomasafumi associationofserumalbuminlevelsandlongtermprognosisinpatientswithbiopsyconfirmednonalcoholicfattyliverdisease AT arakiasuka associationofserumalbuminlevelsandlongtermprognosisinpatientswithbiopsyconfirmednonalcoholicfattyliverdisease AT arakakishingo associationofserumalbuminlevelsandlongtermprognosisinpatientswithbiopsyconfirmednonalcoholicfattyliverdisease AT kawaguchitakumi associationofserumalbuminlevelsandlongtermprognosisinpatientswithbiopsyconfirmednonalcoholicfattyliverdisease AT noritakehidenao associationofserumalbuminlevelsandlongtermprognosisinpatientswithbiopsyconfirmednonalcoholicfattyliverdisease AT onomasafumi associationofserumalbuminlevelsandlongtermprognosisinpatientswithbiopsyconfirmednonalcoholicfattyliverdisease AT masakitsutomu associationofserumalbuminlevelsandlongtermprognosisinpatientswithbiopsyconfirmednonalcoholicfattyliverdisease AT yasudasatoshi associationofserumalbuminlevelsandlongtermprognosisinpatientswithbiopsyconfirmednonalcoholicfattyliverdisease AT tomitaeiichi associationofserumalbuminlevelsandlongtermprognosisinpatientswithbiopsyconfirmednonalcoholicfattyliverdisease AT yonedamasato associationofserumalbuminlevelsandlongtermprognosisinpatientswithbiopsyconfirmednonalcoholicfattyliverdisease AT tokushigeakihiro associationofserumalbuminlevelsandlongtermprognosisinpatientswithbiopsyconfirmednonalcoholicfattyliverdisease AT kamadayoshihiro associationofserumalbuminlevelsandlongtermprognosisinpatientswithbiopsyconfirmednonalcoholicfattyliverdisease AT uedashinichiro associationofserumalbuminlevelsandlongtermprognosisinpatientswithbiopsyconfirmednonalcoholicfattyliverdisease AT aishimashinichi associationofserumalbuminlevelsandlongtermprognosisinpatientswithbiopsyconfirmednonalcoholicfattyliverdisease AT sumidayoshio associationofserumalbuminlevelsandlongtermprognosisinpatientswithbiopsyconfirmednonalcoholicfattyliverdisease AT nakajimaatsushi associationofserumalbuminlevelsandlongtermprognosisinpatientswithbiopsyconfirmednonalcoholicfattyliverdisease AT okanouetakeshi associationofserumalbuminlevelsandlongtermprognosisinpatientswithbiopsyconfirmednonalcoholicfattyliverdisease AT associationofserumalbuminlevelsandlongtermprognosisinpatientswithbiopsyconfirmednonalcoholicfattyliverdisease |