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Association of Serum Albumin Levels and Long-Term Prognosis in Patients with Biopsy-Confirmed Nonalcoholic Fatty Liver Disease

The relationship between baseline serum albumin level and long-term prognosis of patients with nonalcoholic fatty liver disease (NAFLD) remains unknown. This is a sub-analysis of the CLIONE (Clinical Outcome Nonalcoholic Fatty Liver Disease) study. The main outcomes were: death or orthotopic liver t...

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Autores principales: Takahashi, Hirokazu, Kawanaka, Miwa, Fujii, Hideki, Iwaki, Michihiro, Hayashi, Hideki, Toyoda, Hidenori, Oeda, Satoshi, Hyogo, Hideyuki, Morishita, Asahiro, Munekage, Kensuke, Kawata, Kazuhito, Tsutsumi, Tsubasa, Sawada, Koji, Maeshiro, Tatsuji, Tobita, Hiroshi, Yoshida, Yuichi, Naito, Masafumi, Araki, Asuka, Arakaki, Shingo, Kawaguchi, Takumi, Noritake, Hidenao, Ono, Masafumi, Masaki, Tsutomu, Yasuda, Satoshi, Tomita, Eiichi, Yoneda, Masato, Tokushige, Akihiro, Kamada, Yoshihiro, Ueda, Shinichiro, Aishima, Shinichi, Sumida, Yoshio, Nakajima, Atsushi, Okanoue, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180563/
https://www.ncbi.nlm.nih.gov/pubmed/37432160
http://dx.doi.org/10.3390/nu15092014
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author Takahashi, Hirokazu
Kawanaka, Miwa
Fujii, Hideki
Iwaki, Michihiro
Hayashi, Hideki
Toyoda, Hidenori
Oeda, Satoshi
Hyogo, Hideyuki
Morishita, Asahiro
Munekage, Kensuke
Kawata, Kazuhito
Tsutsumi, Tsubasa
Sawada, Koji
Maeshiro, Tatsuji
Tobita, Hiroshi
Yoshida, Yuichi
Naito, Masafumi
Araki, Asuka
Arakaki, Shingo
Kawaguchi, Takumi
Noritake, Hidenao
Ono, Masafumi
Masaki, Tsutomu
Yasuda, Satoshi
Tomita, Eiichi
Yoneda, Masato
Tokushige, Akihiro
Kamada, Yoshihiro
Ueda, Shinichiro
Aishima, Shinichi
Sumida, Yoshio
Nakajima, Atsushi
Okanoue, Takeshi
author_facet Takahashi, Hirokazu
Kawanaka, Miwa
Fujii, Hideki
Iwaki, Michihiro
Hayashi, Hideki
Toyoda, Hidenori
Oeda, Satoshi
Hyogo, Hideyuki
Morishita, Asahiro
Munekage, Kensuke
Kawata, Kazuhito
Tsutsumi, Tsubasa
Sawada, Koji
Maeshiro, Tatsuji
Tobita, Hiroshi
Yoshida, Yuichi
Naito, Masafumi
Araki, Asuka
Arakaki, Shingo
Kawaguchi, Takumi
Noritake, Hidenao
Ono, Masafumi
Masaki, Tsutomu
Yasuda, Satoshi
Tomita, Eiichi
Yoneda, Masato
Tokushige, Akihiro
Kamada, Yoshihiro
Ueda, Shinichiro
Aishima, Shinichi
Sumida, Yoshio
Nakajima, Atsushi
Okanoue, Takeshi
author_sort Takahashi, Hirokazu
collection PubMed
description The relationship between baseline serum albumin level and long-term prognosis of patients with nonalcoholic fatty liver disease (NAFLD) remains unknown. This is a sub-analysis of the CLIONE (Clinical Outcome Nonalcoholic Fatty Liver Disease) study. The main outcomes were: death or orthotopic liver transplantation (OLT), liver-related death, and liver-related events (hepatocellular carcinoma [HCC], decompensated cirrhosis, and gastroesophageal varices/bleeding). 1383 Japanese patients with biopsy-confirmed NAFLD were analyzed. They were divided into 3 groups based on serum albumin: high (>4.0 g/dL), intermediate (3.5–4.0 g/dL), and low (<3.5 g/dL). Unadjusted hazard ratio [HR] of the intermediate albumin group, compared with the high albumin group, were 3.6 for death or OLT, 11.2 for liver-related death, 4.6 for HCC, 8.2 for decompensated cirrhosis, and 6.2 for gastroesophageal varices (all risks were statistically significant). After adjusting confounding factors, albumin remained significantly associated with death or OLT (intermediate vs. high albumin group: HR 3.06, 95% confidence interval [CI] 1.59–5.91, p < 0.001; low vs. high albumin group: HR 22.9, 95% CI 8.21–63.9, p < 0.001). Among biopsy-confirmed NAFLD patients, those with intermediate or low serum albumin had a significantly higher risk of death or OLT than those with high serum albumin.
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spelling pubmed-101805632023-05-13 Association of Serum Albumin Levels and Long-Term Prognosis in Patients with Biopsy-Confirmed Nonalcoholic Fatty Liver Disease Takahashi, Hirokazu Kawanaka, Miwa Fujii, Hideki Iwaki, Michihiro Hayashi, Hideki Toyoda, Hidenori Oeda, Satoshi Hyogo, Hideyuki Morishita, Asahiro Munekage, Kensuke Kawata, Kazuhito Tsutsumi, Tsubasa Sawada, Koji Maeshiro, Tatsuji Tobita, Hiroshi Yoshida, Yuichi Naito, Masafumi Araki, Asuka Arakaki, Shingo Kawaguchi, Takumi Noritake, Hidenao Ono, Masafumi Masaki, Tsutomu Yasuda, Satoshi Tomita, Eiichi Yoneda, Masato Tokushige, Akihiro Kamada, Yoshihiro Ueda, Shinichiro Aishima, Shinichi Sumida, Yoshio Nakajima, Atsushi Okanoue, Takeshi Nutrients Article The relationship between baseline serum albumin level and long-term prognosis of patients with nonalcoholic fatty liver disease (NAFLD) remains unknown. This is a sub-analysis of the CLIONE (Clinical Outcome Nonalcoholic Fatty Liver Disease) study. The main outcomes were: death or orthotopic liver transplantation (OLT), liver-related death, and liver-related events (hepatocellular carcinoma [HCC], decompensated cirrhosis, and gastroesophageal varices/bleeding). 1383 Japanese patients with biopsy-confirmed NAFLD were analyzed. They were divided into 3 groups based on serum albumin: high (>4.0 g/dL), intermediate (3.5–4.0 g/dL), and low (<3.5 g/dL). Unadjusted hazard ratio [HR] of the intermediate albumin group, compared with the high albumin group, were 3.6 for death or OLT, 11.2 for liver-related death, 4.6 for HCC, 8.2 for decompensated cirrhosis, and 6.2 for gastroesophageal varices (all risks were statistically significant). After adjusting confounding factors, albumin remained significantly associated with death or OLT (intermediate vs. high albumin group: HR 3.06, 95% confidence interval [CI] 1.59–5.91, p < 0.001; low vs. high albumin group: HR 22.9, 95% CI 8.21–63.9, p < 0.001). Among biopsy-confirmed NAFLD patients, those with intermediate or low serum albumin had a significantly higher risk of death or OLT than those with high serum albumin. MDPI 2023-04-22 /pmc/articles/PMC10180563/ /pubmed/37432160 http://dx.doi.org/10.3390/nu15092014 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Takahashi, Hirokazu
Kawanaka, Miwa
Fujii, Hideki
Iwaki, Michihiro
Hayashi, Hideki
Toyoda, Hidenori
Oeda, Satoshi
Hyogo, Hideyuki
Morishita, Asahiro
Munekage, Kensuke
Kawata, Kazuhito
Tsutsumi, Tsubasa
Sawada, Koji
Maeshiro, Tatsuji
Tobita, Hiroshi
Yoshida, Yuichi
Naito, Masafumi
Araki, Asuka
Arakaki, Shingo
Kawaguchi, Takumi
Noritake, Hidenao
Ono, Masafumi
Masaki, Tsutomu
Yasuda, Satoshi
Tomita, Eiichi
Yoneda, Masato
Tokushige, Akihiro
Kamada, Yoshihiro
Ueda, Shinichiro
Aishima, Shinichi
Sumida, Yoshio
Nakajima, Atsushi
Okanoue, Takeshi
Association of Serum Albumin Levels and Long-Term Prognosis in Patients with Biopsy-Confirmed Nonalcoholic Fatty Liver Disease
title Association of Serum Albumin Levels and Long-Term Prognosis in Patients with Biopsy-Confirmed Nonalcoholic Fatty Liver Disease
title_full Association of Serum Albumin Levels and Long-Term Prognosis in Patients with Biopsy-Confirmed Nonalcoholic Fatty Liver Disease
title_fullStr Association of Serum Albumin Levels and Long-Term Prognosis in Patients with Biopsy-Confirmed Nonalcoholic Fatty Liver Disease
title_full_unstemmed Association of Serum Albumin Levels and Long-Term Prognosis in Patients with Biopsy-Confirmed Nonalcoholic Fatty Liver Disease
title_short Association of Serum Albumin Levels and Long-Term Prognosis in Patients with Biopsy-Confirmed Nonalcoholic Fatty Liver Disease
title_sort association of serum albumin levels and long-term prognosis in patients with biopsy-confirmed nonalcoholic fatty liver disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180563/
https://www.ncbi.nlm.nih.gov/pubmed/37432160
http://dx.doi.org/10.3390/nu15092014
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