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Biodegradable Polycaprolactone Fibers with Silica Aerogel and Nanosilver Particles Produce a Coagulation Effect

Poly-ε-caprolactone (PCL) is a biodegradable aliphatic polyester that can be used in the field of biomaterials. Electrospinning is the name given to the process of producing micro and nanoscale fibers using electrostatically charged polymeric solutions under certain conditions. Almost all synthetic...

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Detalles Bibliográficos
Autores principales: Ayvazoğlu, Büşra Şengel, Ceylan, Muhammet, Turan, Aybüke A. Isbir, Yılmaz, Elif Burcu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180577/
https://www.ncbi.nlm.nih.gov/pubmed/37177170
http://dx.doi.org/10.3390/polym15092022
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author Ayvazoğlu, Büşra Şengel
Ceylan, Muhammet
Turan, Aybüke A. Isbir
Yılmaz, Elif Burcu
author_facet Ayvazoğlu, Büşra Şengel
Ceylan, Muhammet
Turan, Aybüke A. Isbir
Yılmaz, Elif Burcu
author_sort Ayvazoğlu, Büşra Şengel
collection PubMed
description Poly-ε-caprolactone (PCL) is a biodegradable aliphatic polyester that can be used in the field of biomaterials. Electrospinning is the name given to the process of producing micro and nanoscale fibers using electrostatically charged polymeric solutions under certain conditions. Almost all synthetic and naturally occurring polymers can undergo electrospinning using suitable solvents or mixtures prepared in certain proportions. In this study, silica aerogels were obtained by the sol-gel method. PCL-silica aerogel fibers were synthesized by adding 0.5, 1, 2, and 4% ratios in the PCL solution. Blood contact analysis was performed on the produced fibers with UV-VIS. According to the results obtained, 0.5, 1, 2, and 4% nano-silver were added to the fiber-containing 4% aerogel. Then, SEM-EDS and FTIR analyses were performed on all fibers produced. Antimicrobial tests were performed on fibers containing nano-silver. As a result, high-performance blood coagulation fibers were developed using PCL with aerogel, and an antimicrobial effect was achieved with nano-silver particles. It is thought that the designed surface will be preferred in wound dressing and biomaterial in tissue engineering, as it provides a high amount of cell adhesion with a small amount of blood and contains antimicrobial properties.
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spelling pubmed-101805772023-05-13 Biodegradable Polycaprolactone Fibers with Silica Aerogel and Nanosilver Particles Produce a Coagulation Effect Ayvazoğlu, Büşra Şengel Ceylan, Muhammet Turan, Aybüke A. Isbir Yılmaz, Elif Burcu Polymers (Basel) Article Poly-ε-caprolactone (PCL) is a biodegradable aliphatic polyester that can be used in the field of biomaterials. Electrospinning is the name given to the process of producing micro and nanoscale fibers using electrostatically charged polymeric solutions under certain conditions. Almost all synthetic and naturally occurring polymers can undergo electrospinning using suitable solvents or mixtures prepared in certain proportions. In this study, silica aerogels were obtained by the sol-gel method. PCL-silica aerogel fibers were synthesized by adding 0.5, 1, 2, and 4% ratios in the PCL solution. Blood contact analysis was performed on the produced fibers with UV-VIS. According to the results obtained, 0.5, 1, 2, and 4% nano-silver were added to the fiber-containing 4% aerogel. Then, SEM-EDS and FTIR analyses were performed on all fibers produced. Antimicrobial tests were performed on fibers containing nano-silver. As a result, high-performance blood coagulation fibers were developed using PCL with aerogel, and an antimicrobial effect was achieved with nano-silver particles. It is thought that the designed surface will be preferred in wound dressing and biomaterial in tissue engineering, as it provides a high amount of cell adhesion with a small amount of blood and contains antimicrobial properties. MDPI 2023-04-24 /pmc/articles/PMC10180577/ /pubmed/37177170 http://dx.doi.org/10.3390/polym15092022 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ayvazoğlu, Büşra Şengel
Ceylan, Muhammet
Turan, Aybüke A. Isbir
Yılmaz, Elif Burcu
Biodegradable Polycaprolactone Fibers with Silica Aerogel and Nanosilver Particles Produce a Coagulation Effect
title Biodegradable Polycaprolactone Fibers with Silica Aerogel and Nanosilver Particles Produce a Coagulation Effect
title_full Biodegradable Polycaprolactone Fibers with Silica Aerogel and Nanosilver Particles Produce a Coagulation Effect
title_fullStr Biodegradable Polycaprolactone Fibers with Silica Aerogel and Nanosilver Particles Produce a Coagulation Effect
title_full_unstemmed Biodegradable Polycaprolactone Fibers with Silica Aerogel and Nanosilver Particles Produce a Coagulation Effect
title_short Biodegradable Polycaprolactone Fibers with Silica Aerogel and Nanosilver Particles Produce a Coagulation Effect
title_sort biodegradable polycaprolactone fibers with silica aerogel and nanosilver particles produce a coagulation effect
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180577/
https://www.ncbi.nlm.nih.gov/pubmed/37177170
http://dx.doi.org/10.3390/polym15092022
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AT turanaybukeaisbir biodegradablepolycaprolactonefiberswithsilicaaerogelandnanosilverparticlesproduceacoagulationeffect
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