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Metal Nanoparticle-Flavonoid Connections: Synthesis, Physicochemical and Biological Properties, as Well as Potential Applications in Medicine

Flavonoids are polyphenolic compounds widely occurring throughout the plant kingdom. They are biologically active and have many medical applications. Flavonoids reveal chemopreventive, anticarcinogenic, and antioxidant properties, as well as being able to modulate the immune system response and inhi...

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Autores principales: Sysak, Stepan, Czarczynska-Goslinska, Beata, Szyk, Piotr, Koczorowski, Tomasz, Mlynarczyk, Dariusz T., Szczolko, Wojciech, Lesyk, Roman, Goslinski, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180592/
https://www.ncbi.nlm.nih.gov/pubmed/37177076
http://dx.doi.org/10.3390/nano13091531
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author Sysak, Stepan
Czarczynska-Goslinska, Beata
Szyk, Piotr
Koczorowski, Tomasz
Mlynarczyk, Dariusz T.
Szczolko, Wojciech
Lesyk, Roman
Goslinski, Tomasz
author_facet Sysak, Stepan
Czarczynska-Goslinska, Beata
Szyk, Piotr
Koczorowski, Tomasz
Mlynarczyk, Dariusz T.
Szczolko, Wojciech
Lesyk, Roman
Goslinski, Tomasz
author_sort Sysak, Stepan
collection PubMed
description Flavonoids are polyphenolic compounds widely occurring throughout the plant kingdom. They are biologically active and have many medical applications. Flavonoids reveal chemopreventive, anticarcinogenic, and antioxidant properties, as well as being able to modulate the immune system response and inhibit inflammation, angiogenesis, and metastasis. Polyphenols are also believed to reverse multidrug resistance via various mechanisms, induce apoptosis, and activate cell death signals in tumor cells by modulating cell signaling pathways. The main limitation to the broader usage of flavonoids is their low solubility, poor absorption, and rapid metabolism. To tackle this, the combining of flavonoids with nanocarriers could improve their bioavailability and create systems of wider functionalities. Recently, interest in hybrid materials based on combinations of metal nanoparticles with flavonoids has increased due to their unique physicochemical and biological properties, including improved selectivity toward target sites. In addition, flavonoids have further utilities, even in the initial step of preparation of metal nanomaterials. The review offers knowledge on multiple possibilities of the synthesis of flavonoid-metal nanoparticle conjugates, as well as presents some of their features such as size, shape, surface charge, and stability. The flavonoid-metal nanoparticles are also discussed regarding their biological properties and potential medical applications.
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spelling pubmed-101805922023-05-13 Metal Nanoparticle-Flavonoid Connections: Synthesis, Physicochemical and Biological Properties, as Well as Potential Applications in Medicine Sysak, Stepan Czarczynska-Goslinska, Beata Szyk, Piotr Koczorowski, Tomasz Mlynarczyk, Dariusz T. Szczolko, Wojciech Lesyk, Roman Goslinski, Tomasz Nanomaterials (Basel) Review Flavonoids are polyphenolic compounds widely occurring throughout the plant kingdom. They are biologically active and have many medical applications. Flavonoids reveal chemopreventive, anticarcinogenic, and antioxidant properties, as well as being able to modulate the immune system response and inhibit inflammation, angiogenesis, and metastasis. Polyphenols are also believed to reverse multidrug resistance via various mechanisms, induce apoptosis, and activate cell death signals in tumor cells by modulating cell signaling pathways. The main limitation to the broader usage of flavonoids is their low solubility, poor absorption, and rapid metabolism. To tackle this, the combining of flavonoids with nanocarriers could improve their bioavailability and create systems of wider functionalities. Recently, interest in hybrid materials based on combinations of metal nanoparticles with flavonoids has increased due to their unique physicochemical and biological properties, including improved selectivity toward target sites. In addition, flavonoids have further utilities, even in the initial step of preparation of metal nanomaterials. The review offers knowledge on multiple possibilities of the synthesis of flavonoid-metal nanoparticle conjugates, as well as presents some of their features such as size, shape, surface charge, and stability. The flavonoid-metal nanoparticles are also discussed regarding their biological properties and potential medical applications. MDPI 2023-05-02 /pmc/articles/PMC10180592/ /pubmed/37177076 http://dx.doi.org/10.3390/nano13091531 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sysak, Stepan
Czarczynska-Goslinska, Beata
Szyk, Piotr
Koczorowski, Tomasz
Mlynarczyk, Dariusz T.
Szczolko, Wojciech
Lesyk, Roman
Goslinski, Tomasz
Metal Nanoparticle-Flavonoid Connections: Synthesis, Physicochemical and Biological Properties, as Well as Potential Applications in Medicine
title Metal Nanoparticle-Flavonoid Connections: Synthesis, Physicochemical and Biological Properties, as Well as Potential Applications in Medicine
title_full Metal Nanoparticle-Flavonoid Connections: Synthesis, Physicochemical and Biological Properties, as Well as Potential Applications in Medicine
title_fullStr Metal Nanoparticle-Flavonoid Connections: Synthesis, Physicochemical and Biological Properties, as Well as Potential Applications in Medicine
title_full_unstemmed Metal Nanoparticle-Flavonoid Connections: Synthesis, Physicochemical and Biological Properties, as Well as Potential Applications in Medicine
title_short Metal Nanoparticle-Flavonoid Connections: Synthesis, Physicochemical and Biological Properties, as Well as Potential Applications in Medicine
title_sort metal nanoparticle-flavonoid connections: synthesis, physicochemical and biological properties, as well as potential applications in medicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180592/
https://www.ncbi.nlm.nih.gov/pubmed/37177076
http://dx.doi.org/10.3390/nano13091531
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