Cargando…

Predicting the spread of covid-19 and the impact of government measures at the early stage of the pandemic: The Dutch case—Stricter but short-term measures are better

In this paper, we investigate the spread of COVID-19 and the impact of government measures at the early stage of the pandemic (before the introduction of the vaccines) in the Netherlands. We build a multiple linear regression model to predict the effective reproduction rate using key factors and mea...

Descripción completa

Detalles Bibliográficos
Autores principales: Tenhagen, Cyrelle J., Topan, Engin, Groothuis-Oudshoorn, Karin C. G. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180597/
https://www.ncbi.nlm.nih.gov/pubmed/37172041
http://dx.doi.org/10.1371/journal.pone.0283086
_version_ 1785041372601909248
author Tenhagen, Cyrelle J.
Topan, Engin
Groothuis-Oudshoorn, Karin C. G. M.
author_facet Tenhagen, Cyrelle J.
Topan, Engin
Groothuis-Oudshoorn, Karin C. G. M.
author_sort Tenhagen, Cyrelle J.
collection PubMed
description In this paper, we investigate the spread of COVID-19 and the impact of government measures at the early stage of the pandemic (before the introduction of the vaccines) in the Netherlands. We build a multiple linear regression model to predict the effective reproduction rate using key factors and measures and integrate it with a system dynamics model to predict the spread and the impact of measures against COVID-19. Data from February to November 2020 is used to train the model and data until December 2020 is used to validate the model. We use data about the key factors, e.g., disease specific such as basic reproduction rate and incubation period, weather related factors such as temperature, and controllable factors such as testing capacity. We consider particularly the following measures taken by the government: wearing facemasks, event allowance, school closure, catering services closure, and self-quarantine. Studying the strategy of the Dutch government, we control these measures by following four main policies: doing nothing, mitigation, curbing, elimination. We develop a systems dynamic model to simulate the effect of policies. Based on our numerical experiments, we develop the following main insights: It is more effective to implement strict, sharp measures earlier but for a shorter duration than to introduce measures gradually for a longer duration. This way, we can prevent a quick rise in the number of infected cases but also to reduce the number of days under measures. Combining the measures with a high testing capacity and with effective self-quarantine can significantly reduce the spread of COVID-19.
format Online
Article
Text
id pubmed-10180597
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-101805972023-05-13 Predicting the spread of covid-19 and the impact of government measures at the early stage of the pandemic: The Dutch case—Stricter but short-term measures are better Tenhagen, Cyrelle J. Topan, Engin Groothuis-Oudshoorn, Karin C. G. M. PLoS One Research Article In this paper, we investigate the spread of COVID-19 and the impact of government measures at the early stage of the pandemic (before the introduction of the vaccines) in the Netherlands. We build a multiple linear regression model to predict the effective reproduction rate using key factors and measures and integrate it with a system dynamics model to predict the spread and the impact of measures against COVID-19. Data from February to November 2020 is used to train the model and data until December 2020 is used to validate the model. We use data about the key factors, e.g., disease specific such as basic reproduction rate and incubation period, weather related factors such as temperature, and controllable factors such as testing capacity. We consider particularly the following measures taken by the government: wearing facemasks, event allowance, school closure, catering services closure, and self-quarantine. Studying the strategy of the Dutch government, we control these measures by following four main policies: doing nothing, mitigation, curbing, elimination. We develop a systems dynamic model to simulate the effect of policies. Based on our numerical experiments, we develop the following main insights: It is more effective to implement strict, sharp measures earlier but for a shorter duration than to introduce measures gradually for a longer duration. This way, we can prevent a quick rise in the number of infected cases but also to reduce the number of days under measures. Combining the measures with a high testing capacity and with effective self-quarantine can significantly reduce the spread of COVID-19. Public Library of Science 2023-05-12 /pmc/articles/PMC10180597/ /pubmed/37172041 http://dx.doi.org/10.1371/journal.pone.0283086 Text en © 2023 Tenhagen et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Tenhagen, Cyrelle J.
Topan, Engin
Groothuis-Oudshoorn, Karin C. G. M.
Predicting the spread of covid-19 and the impact of government measures at the early stage of the pandemic: The Dutch case—Stricter but short-term measures are better
title Predicting the spread of covid-19 and the impact of government measures at the early stage of the pandemic: The Dutch case—Stricter but short-term measures are better
title_full Predicting the spread of covid-19 and the impact of government measures at the early stage of the pandemic: The Dutch case—Stricter but short-term measures are better
title_fullStr Predicting the spread of covid-19 and the impact of government measures at the early stage of the pandemic: The Dutch case—Stricter but short-term measures are better
title_full_unstemmed Predicting the spread of covid-19 and the impact of government measures at the early stage of the pandemic: The Dutch case—Stricter but short-term measures are better
title_short Predicting the spread of covid-19 and the impact of government measures at the early stage of the pandemic: The Dutch case—Stricter but short-term measures are better
title_sort predicting the spread of covid-19 and the impact of government measures at the early stage of the pandemic: the dutch case—stricter but short-term measures are better
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180597/
https://www.ncbi.nlm.nih.gov/pubmed/37172041
http://dx.doi.org/10.1371/journal.pone.0283086
work_keys_str_mv AT tenhagencyrellej predictingthespreadofcovid19andtheimpactofgovernmentmeasuresattheearlystageofthepandemicthedutchcasestricterbutshorttermmeasuresarebetter
AT topanengin predictingthespreadofcovid19andtheimpactofgovernmentmeasuresattheearlystageofthepandemicthedutchcasestricterbutshorttermmeasuresarebetter
AT groothuisoudshoornkarincgm predictingthespreadofcovid19andtheimpactofgovernmentmeasuresattheearlystageofthepandemicthedutchcasestricterbutshorttermmeasuresarebetter