Cargando…

A multi-center, prospective cohort study of whole blood gene expression in the tuberculosis-diabetes interaction

Diabetes mellitus (DM) increases tuberculosis (TB) severity. We compared blood gene expression in adults with pulmonary TB, with or without diabetes mellitus (DM) from sites in Brazil and India. RNA sequencing (RNAseq) performed at baseline and during TB treatment. Publicly available baseline RNAseq...

Descripción completa

Detalles Bibliográficos
Autores principales:	Queiroz, Artur T. L., Vinhaes, Caian L., Fukutani, Eduardo R., Gupte, Akshay N., Kumar, Nathella Pavan, Fukutani, Kiyoshi F., Arriaga, María B., Sterling, Timothy R., Babu, Subash, Gaikwad, Sanjay, Karyakarte, Rajesh, Mave, Vidya, Paradhkar, Mandar, Viswanathan, Vijay, Gupta, Amita, Andrade, Bruno B., Kornfeld, Hardy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180618/ https://www.ncbi.nlm.nih.gov/pubmed/37173394 http://dx.doi.org/10.1038/s41598-023-34847-9

Ejemplares similares

Aging increases the systemic molecular degree of inflammatory perturbation in patients with tuberculosis
por: Oliveira-de-Souza, Deivide, et al.
Publicado: (2020)

Persistent inflammation during anti-tuberculosis treatment with diabetes comorbidity
por: Kumar, Nathella Pavan, et al.
Publicado: (2019)

Baseline IL-6 is a biomarker for unfavorable tuberculosis treatment outcomes: a multi-site discovery and validation study
por: Gupte, Akshay N., et al.
Publicado: (2022)

In silico transcriptional analysis of mRNA and miRNA reveals unique biosignatures that characterizes different types of diabetes
por: Cubillos-Angulo, Juan M., et al.
Publicado: (2020)

Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications
por: Prada-Medina, Cesar A., et al.
Publicado: (2017)

Higher interleukin-6 levels and changes in transforming growth factor-β are associated with lung impairment in pulmonary tuberculosis
por: Gupte, Akshay N., et al.
Publicado: (2021)

Effect of anti-tuberculosis treatment on the systemic levels of tissue inhibitors of metalloproteinases in tuberculosis – Diabetes co-morbidity
por: Kumar, Nathella Pavan, et al.
Publicado: (2021)

Heightened circulating levels of antimicrobial peptides in tuberculosis—Diabetes co-morbidity and reversal upon treatment
por: Kumar, Nathella Pavan, et al.
Publicado: (2017)

Dissecting disease tolerance in Plasmodium vivax malaria using the systemic degree of inflammatory perturbation
por: Vinhaes, Caian L., et al.
Publicado: (2021)

Integration of metabolomics and transcriptomics reveals novel biomarkers in the blood for tuberculosis diagnosis in children
por: Dutta, Noton K., et al.
Publicado: (2020)

Plasma Eicosanoid Levels in Tuberculosis and Tuberculosis-Diabetes Co-morbidity Are Associated With Lung Pathology and Bacterial Burden
por: Pavan Kumar, Nathella, et al.
Publicado: (2019)

Systemic RAGE ligands are upregulated in tuberculosis individuals with diabetes co-morbidity and modulated by anti-tuberculosis treatment and metformin therapy
por: Kumar, Nathella Pavan, et al.
Publicado: (2019)

Acute Phase Proteins Are Baseline Predictors of Tuberculosis Treatment Failure
por: Kumar, Nathella Pavan, et al.
Publicado: (2021)

Molecular degree of perturbation of plasma inflammatory markers associated with tuberculosis reveals distinct disease profiles between Indian and Chinese populations
por: Oliveira-de-Souza, Deivide, et al.
Publicado: (2019)

Chitinase and indoleamine 2, 3-dioxygenase are prognostic biomarkers for unfavorable treatment outcomes in pulmonary tuberculosis
por: Kumar, Nathella Pavan, et al.
Publicado: (2023)

Host Inflammatory Biomarkers of Disease Severity in Pediatric Community-Acquired Pneumonia: A Systematic Review and Meta-analysis
por: Fernandes, Catarina D, et al.
Publicado: (2019)

Elevated levels of matrix metalloproteinases reflect severity and extent of disease in tuberculosis-diabetes co-morbidity and are predominantly reversed following standard anti-tuberculosis or metformin treatment
por: Kumar, Nathella P., et al.
Publicado: (2018)

Plasma chemokines are biomarkers of disease severity, higher bacterial burden and delayed sputum culture conversion in pulmonary tuberculosis
por: Kumar, Nathella P., et al.
Publicado: (2019)

Coincident Pre-Diabetes Is Associated with Dysregulated Cytokine Responses in Pulmonary Tuberculosis
por: Kumar, Nathella Pavan, et al.
Publicado: (2014)

Multifocal tuberculosis-associated immune reconstitution inflammatory syndrome – a case report of a complicated scenario
por: Narendran, Gopalan, et al.
Publicado: (2019)

Systems biology analysis of publicly available transcriptomic data reveals a critical link between AKR1B10 gene expression, smoking and occurrence of lung cancer
por: Cubillos-Angulo, Juan M., et al.
Publicado: (2020)

Association of Plasma Matrix Metalloproteinase and Tissue Inhibitors of Matrix Metalloproteinase Levels With Adverse Treatment Outcomes Among Patients With Pulmonary Tuberculosis
por: Kumar, Nathella P., et al.
Publicado: (2020)

Impact of diabetes mellitus on immunity to latent tuberculosis infection
por: Kumar, Nathella Pavan, et al.
Publicado: (2023)

Correlation Between SARS-Cov-2 Vaccination, COVID-19 Incidence and Mortality: Tracking the Effect of Vaccination on Population Protection in Real Time
por: Fukutani, Kiyoshi F., et al.
Publicado: (2021)

Chronic Hepatitis B Infection Is Associated with Increased Molecular Degree of Inflammatory Perturbation in Peripheral Blood
por: Vinhaes, Caian L., et al.
Publicado: (2020)

Diabetes Mellitus and Tuberculosis Treatment Outcomes in Pune, India
por: Mave, Vidya, et al.
Publicado: (2021)

Incidence of tuberculosis in HIV-infected adults on first- and second-line antiretroviral therapy in India
por: Gupte, Akshay N., et al.
Publicado: (2019)

The Kynurenine/Tryptophan Ratio Is a Sensitive Biomarker for the Diagnosis of Pediatric Tuberculosis Among Indian Children
por: Tornheim, Jeffrey A., et al.
Publicado: (2022)

Circulating Angiogenic Factors as Biomarkers of Disease Severity and Bacterial Burden in Pulmonary Tuberculosis
por: Kumar, Nathella Pavan, et al.
Publicado: (2016)

Diminished plasma levels of common γ-chain cytokines in pulmonary tuberculosis and reversal following treatment
por: Kumar, Nathella Pavan, et al.
Publicado: (2017)

Smoking, alcohol use disorder and tuberculosis treatment outcomes: A dual co-morbidity burden that cannot be ignored
por: Thomas, Beena Elizabeth, et al.
Publicado: (2019)

Correction: Smoking, alcohol use disorder and tuberculosis treatment outcomes: A dual co-morbidity burden that cannot be ignored
por: Thomas, Beena Elizabeth, et al.
Publicado: (2019)

Differential expression of CXCR3 and CCR6 on CD4(+) T-lymphocytes with distinct memory phenotypes characterizes tuberculosis-associated immune reconstitution inflammatory syndrome
por: Silveira-Mattos, Paulo S., et al.
Publicado: (2019)

Author Correction: Differential expression of CXCR3 and CCR6 on CD4(+) T-lymphocytes with distinct memory phenotypes characterizes tuberculosis-associated immune reconstitution inflammatory syndrome
por: Silveira-Mattos, Paulo S., et al.
Publicado: (2019)

Prediabetes is associated with the modulation of antigen-specific Th1/Tc1 and Th17/Tc17 responses in latent Mycobacterium tuberculosis infection
por: Kumar, Nathella Pavan, et al.
Publicado: (2017)

NK-CD11c+ Cell Crosstalk in Diabetes Enhances IL-6-Mediated Inflammation during Mycobacterium tuberculosis Infection
por: Cheekatla, Satyanarayana Swamy, et al.
Publicado: (2016)

Addressing knowledge gaps and prevention for tuberculosis-infected Indian adults: a vital part of elimination
por: DeLuca, Andrea, et al.
Publicado: (2018)

Comparative immune responses to Mycobacterium tuberculosis in people with latent infection or sterilizing protection
por: Jalbert, Emilie, et al.
Publicado: (2023)

Follow up of a robust meta-signature to identify Zika virus infection in Aedes aegypti: another brick in the wall
por: Fukutani, Eduardo, et al.
Publicado: (2018)

1953. Impact of Baseline Nutritional Status on Tuberculosis Severity in India: a multicenter prospective cohort analysis
por: Du, Xinyi, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_hpe8rfv1b5au8tn3kqoiaf2eci