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Clinical Outcomes of the Deleterious Effects of Aluminum on Neuro-Cognition, Inflammation, and Health: A Review

Introduction: In the scenario of metal toxicity, aluminum (Al) stands out as a ubiquitous type of metal that can be combined with other elements and form different compounds. Al is widely used daily as an adjuvant in vaccines, antacids, food additives (as components of AI-containing food additives),...

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Autores principales: Renke, Guilherme, Almeida, Vanessa Borges Pinheiro, Souza, Everton Almeida, Lessa, Suzana, Teixeira, Raila Linhares, Rocha, Leticia, Sousa, Pamela Lopes, Starling-Soares, Bernardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180736/
https://www.ncbi.nlm.nih.gov/pubmed/37432384
http://dx.doi.org/10.3390/nu15092221
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author Renke, Guilherme
Almeida, Vanessa Borges Pinheiro
Souza, Everton Almeida
Lessa, Suzana
Teixeira, Raila Linhares
Rocha, Leticia
Sousa, Pamela Lopes
Starling-Soares, Bernardo
author_facet Renke, Guilherme
Almeida, Vanessa Borges Pinheiro
Souza, Everton Almeida
Lessa, Suzana
Teixeira, Raila Linhares
Rocha, Leticia
Sousa, Pamela Lopes
Starling-Soares, Bernardo
author_sort Renke, Guilherme
collection PubMed
description Introduction: In the scenario of metal toxicity, aluminum (Al) stands out as a ubiquitous type of metal that can be combined with other elements and form different compounds. Al is widely used daily as an adjuvant in vaccines, antacids, food additives (as components of AI-containing food additives), skin care products, cosmetics, and kitchenware, and can be an element or contaminant present in our daily life. Objective: To present a review of the main deleterious effects of Al on human health. Methods: The search was carried out from September 2022 to February 2023 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases, using scientific articles from 2012 to 2023. The quality of the studies was based on the GRADE instrument, and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusions: A total of 115 files were search returned. Further, 95 articles were evaluated, and 44 were included in this review. Based on the results, measuring Al’s relevance to health is essential in medicine. Several studies have demonstrated clinical outcomes and metabolic alterations with Al exposure. The tolerable weekly intake established by the European Food Safety Authority (EFSA) of 1 mg Al/kg body weight can be achieved through dietary exposure alone. Proven neurotoxicity in humans is the critical adverse effect of Al. A carcinogenic effect of Al has not been proven so far. Preventive medicine advocates that exposure to Al should be kept as low as possible. Chelating agents, such as calcium disodium ethylene diamine tetraacetic acid and deferoxamine, are options for acute poisoning, and monomethysilanetriol supplementation may be a long-term strategy with chelation potential. Further studies are needed to assess the impacts of Al on human health.
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spelling pubmed-101807362023-05-13 Clinical Outcomes of the Deleterious Effects of Aluminum on Neuro-Cognition, Inflammation, and Health: A Review Renke, Guilherme Almeida, Vanessa Borges Pinheiro Souza, Everton Almeida Lessa, Suzana Teixeira, Raila Linhares Rocha, Leticia Sousa, Pamela Lopes Starling-Soares, Bernardo Nutrients Review Introduction: In the scenario of metal toxicity, aluminum (Al) stands out as a ubiquitous type of metal that can be combined with other elements and form different compounds. Al is widely used daily as an adjuvant in vaccines, antacids, food additives (as components of AI-containing food additives), skin care products, cosmetics, and kitchenware, and can be an element or contaminant present in our daily life. Objective: To present a review of the main deleterious effects of Al on human health. Methods: The search was carried out from September 2022 to February 2023 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases, using scientific articles from 2012 to 2023. The quality of the studies was based on the GRADE instrument, and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusions: A total of 115 files were search returned. Further, 95 articles were evaluated, and 44 were included in this review. Based on the results, measuring Al’s relevance to health is essential in medicine. Several studies have demonstrated clinical outcomes and metabolic alterations with Al exposure. The tolerable weekly intake established by the European Food Safety Authority (EFSA) of 1 mg Al/kg body weight can be achieved through dietary exposure alone. Proven neurotoxicity in humans is the critical adverse effect of Al. A carcinogenic effect of Al has not been proven so far. Preventive medicine advocates that exposure to Al should be kept as low as possible. Chelating agents, such as calcium disodium ethylene diamine tetraacetic acid and deferoxamine, are options for acute poisoning, and monomethysilanetriol supplementation may be a long-term strategy with chelation potential. Further studies are needed to assess the impacts of Al on human health. MDPI 2023-05-08 /pmc/articles/PMC10180736/ /pubmed/37432384 http://dx.doi.org/10.3390/nu15092221 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Renke, Guilherme
Almeida, Vanessa Borges Pinheiro
Souza, Everton Almeida
Lessa, Suzana
Teixeira, Raila Linhares
Rocha, Leticia
Sousa, Pamela Lopes
Starling-Soares, Bernardo
Clinical Outcomes of the Deleterious Effects of Aluminum on Neuro-Cognition, Inflammation, and Health: A Review
title Clinical Outcomes of the Deleterious Effects of Aluminum on Neuro-Cognition, Inflammation, and Health: A Review
title_full Clinical Outcomes of the Deleterious Effects of Aluminum on Neuro-Cognition, Inflammation, and Health: A Review
title_fullStr Clinical Outcomes of the Deleterious Effects of Aluminum on Neuro-Cognition, Inflammation, and Health: A Review
title_full_unstemmed Clinical Outcomes of the Deleterious Effects of Aluminum on Neuro-Cognition, Inflammation, and Health: A Review
title_short Clinical Outcomes of the Deleterious Effects of Aluminum on Neuro-Cognition, Inflammation, and Health: A Review
title_sort clinical outcomes of the deleterious effects of aluminum on neuro-cognition, inflammation, and health: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180736/
https://www.ncbi.nlm.nih.gov/pubmed/37432384
http://dx.doi.org/10.3390/nu15092221
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