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Feasibility of high-yield plateletpheresis in routine practice: Experience from tertiary health center from South India

BACKGROUND AND OBJECTIVES: High-yield plateletpheresis donations can reduce donor exposure and be economically beneficial as well. However, obtaining a high-yield plateletpheresis from a maximum number of donors with low basal platelet count and its effect on postdonation platelet count of donors un...

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Autores principales: Sahoo, Dibyajyoti, Noushad, Shahida, Basavarajegowda, Abhishekh, Toora, Esha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180781/
https://www.ncbi.nlm.nih.gov/pubmed/37188018
http://dx.doi.org/10.4103/ajts.ajts_103_21
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author Sahoo, Dibyajyoti
Noushad, Shahida
Basavarajegowda, Abhishekh
Toora, Esha
author_facet Sahoo, Dibyajyoti
Noushad, Shahida
Basavarajegowda, Abhishekh
Toora, Esha
author_sort Sahoo, Dibyajyoti
collection PubMed
description BACKGROUND AND OBJECTIVES: High-yield plateletpheresis donations can reduce donor exposure and be economically beneficial as well. However, obtaining a high-yield plateletpheresis from a maximum number of donors with low basal platelet count and its effect on postdonation platelet count of donors undergoing high-yield plateletpheresis has been a matter of concern. This study aimed to assess the feasibility of making high-yield platelet donation as a routine practice. METHODS: It was a retrospective observational study to determine the effect of high-yield plateletpheresis on donor reactions, efficacy, and quality parameters. It was conducted from January 1, 2019 to June 30, 2021, at the Department of Transfusion Medicine in a tertiary care hospital of South India. RESULTS: Out of the 669 procedures, 564 (84.3%) of the collection had a platelet yield of ≥5 × 10(11), 468 (70%) of the collection had a platelet yield of 5.5 × 10(11,) whereas 284 (42.5%) met the target of 6 × 10(11) by coulter. The mean drops in platelet count were 95 ± 16 × 10(3)/μl (77,600–113,000/μl), mean platelet recruitment was 1.31 ± 0.51. The mean collection efficiency of the procedure for the 669 cases was shown to be 80.21 ± 15.34, and the mean collection rate was 0.07 × 10(11) ± 0.02 per minute. Only forty donors (5.5%) experienced adverse donor reactions. CONCLUSIONS: High-yield plateletpheresis can be done in routine practice with no added adverse donor reaction with effective quality products.
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spelling pubmed-101807812023-05-13 Feasibility of high-yield plateletpheresis in routine practice: Experience from tertiary health center from South India Sahoo, Dibyajyoti Noushad, Shahida Basavarajegowda, Abhishekh Toora, Esha Asian J Transfus Sci Original Article BACKGROUND AND OBJECTIVES: High-yield plateletpheresis donations can reduce donor exposure and be economically beneficial as well. However, obtaining a high-yield plateletpheresis from a maximum number of donors with low basal platelet count and its effect on postdonation platelet count of donors undergoing high-yield plateletpheresis has been a matter of concern. This study aimed to assess the feasibility of making high-yield platelet donation as a routine practice. METHODS: It was a retrospective observational study to determine the effect of high-yield plateletpheresis on donor reactions, efficacy, and quality parameters. It was conducted from January 1, 2019 to June 30, 2021, at the Department of Transfusion Medicine in a tertiary care hospital of South India. RESULTS: Out of the 669 procedures, 564 (84.3%) of the collection had a platelet yield of ≥5 × 10(11), 468 (70%) of the collection had a platelet yield of 5.5 × 10(11,) whereas 284 (42.5%) met the target of 6 × 10(11) by coulter. The mean drops in platelet count were 95 ± 16 × 10(3)/μl (77,600–113,000/μl), mean platelet recruitment was 1.31 ± 0.51. The mean collection efficiency of the procedure for the 669 cases was shown to be 80.21 ± 15.34, and the mean collection rate was 0.07 × 10(11) ± 0.02 per minute. Only forty donors (5.5%) experienced adverse donor reactions. CONCLUSIONS: High-yield plateletpheresis can be done in routine practice with no added adverse donor reaction with effective quality products. Wolters Kluwer - Medknow 2023 2022-09-28 /pmc/articles/PMC10180781/ /pubmed/37188018 http://dx.doi.org/10.4103/ajts.ajts_103_21 Text en Copyright: © 2022 Asian Journal of Transfusion Science https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Sahoo, Dibyajyoti
Noushad, Shahida
Basavarajegowda, Abhishekh
Toora, Esha
Feasibility of high-yield plateletpheresis in routine practice: Experience from tertiary health center from South India
title Feasibility of high-yield plateletpheresis in routine practice: Experience from tertiary health center from South India
title_full Feasibility of high-yield plateletpheresis in routine practice: Experience from tertiary health center from South India
title_fullStr Feasibility of high-yield plateletpheresis in routine practice: Experience from tertiary health center from South India
title_full_unstemmed Feasibility of high-yield plateletpheresis in routine practice: Experience from tertiary health center from South India
title_short Feasibility of high-yield plateletpheresis in routine practice: Experience from tertiary health center from South India
title_sort feasibility of high-yield plateletpheresis in routine practice: experience from tertiary health center from south india
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180781/
https://www.ncbi.nlm.nih.gov/pubmed/37188018
http://dx.doi.org/10.4103/ajts.ajts_103_21
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AT basavarajegowdaabhishekh feasibilityofhighyieldplateletpheresisinroutinepracticeexperiencefromtertiaryhealthcenterfromsouthindia
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