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Comparison of platelet indices in dengue fever patients based on platelet transfusion: A prospective observational study in a tertiary care center

CONTEXT: Dengue fever is the most prevalent mosquito-borne viral disease in humans. Platelet indices (PIs) are given by the cell counters but are often not reported which is possibly due to under-recognition of the utility of these parameters. AIMS: This study aimed to compare PIs in patients with d...

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Autores principales: Asha, J., Baiju, Nithya M., Innah, Susheela J., Rafi, Aboobacker, John, Bins M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180782/
https://www.ncbi.nlm.nih.gov/pubmed/37188027
http://dx.doi.org/10.4103/ajts.AJTS_24_20
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author Asha, J.
Baiju, Nithya M.
Innah, Susheela J.
Rafi, Aboobacker
John, Bins M.
author_facet Asha, J.
Baiju, Nithya M.
Innah, Susheela J.
Rafi, Aboobacker
John, Bins M.
author_sort Asha, J.
collection PubMed
description CONTEXT: Dengue fever is the most prevalent mosquito-borne viral disease in humans. Platelet indices (PIs) are given by the cell counters but are often not reported which is possibly due to under-recognition of the utility of these parameters. AIMS: This study aimed to compare PIs in patients with dengue fever to assess their role in the outcome such as hospital stay and platelet transfusion requirements. SETTINGS AND DESIGN: Prospective observational study in a tertiary care center, Thrissur, Kerala. SUBJECTS AND METHODS: A group of 250 dengue patients was studied over a period of 18 months. The platelet parameters (platelet count, mean platelet volume [MPV], platelet distribution width [PDW], platelet large cell ratio [PLCR], plateletcrit [PCT] and immature platelet fraction [IPF]) were measured with Sysmex XN-1000 and followed up every 24 h. The clinical features, duration of hospital stay and platelet transfusion requirements details were collected. STATISTICAL ANALYSIS USED: Independent t-test, Chi-square test, Karl Pearson correlation coefficient. RESULTS: A total of sample size was 250. The study showed normal PDW and MPV, low platelet count and PCT, and high PLCR and IPF in dengue patients. There were significant differences in PIs (lower platelet count and PCT, higher MPV, PDW, PLCR, and IPF) in comparison between dengue patients based on platelet transfusion. CONCLUSIONS: PIs may act as a predictive tool in the diagnosis and predicting outcomes in dengue fever. Low platelet count and PCT, high PDW, MPV, PLCR, and IPF in transfused dengue patients were found to be statistically significant. Clinicians need to be sensitized about the utility and limitations of these indices and rationalize the need for red cell and platelet transfusions in dengue.
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spelling pubmed-101807822023-05-13 Comparison of platelet indices in dengue fever patients based on platelet transfusion: A prospective observational study in a tertiary care center Asha, J. Baiju, Nithya M. Innah, Susheela J. Rafi, Aboobacker John, Bins M. Asian J Transfus Sci Original Article CONTEXT: Dengue fever is the most prevalent mosquito-borne viral disease in humans. Platelet indices (PIs) are given by the cell counters but are often not reported which is possibly due to under-recognition of the utility of these parameters. AIMS: This study aimed to compare PIs in patients with dengue fever to assess their role in the outcome such as hospital stay and platelet transfusion requirements. SETTINGS AND DESIGN: Prospective observational study in a tertiary care center, Thrissur, Kerala. SUBJECTS AND METHODS: A group of 250 dengue patients was studied over a period of 18 months. The platelet parameters (platelet count, mean platelet volume [MPV], platelet distribution width [PDW], platelet large cell ratio [PLCR], plateletcrit [PCT] and immature platelet fraction [IPF]) were measured with Sysmex XN-1000 and followed up every 24 h. The clinical features, duration of hospital stay and platelet transfusion requirements details were collected. STATISTICAL ANALYSIS USED: Independent t-test, Chi-square test, Karl Pearson correlation coefficient. RESULTS: A total of sample size was 250. The study showed normal PDW and MPV, low platelet count and PCT, and high PLCR and IPF in dengue patients. There were significant differences in PIs (lower platelet count and PCT, higher MPV, PDW, PLCR, and IPF) in comparison between dengue patients based on platelet transfusion. CONCLUSIONS: PIs may act as a predictive tool in the diagnosis and predicting outcomes in dengue fever. Low platelet count and PCT, high PDW, MPV, PLCR, and IPF in transfused dengue patients were found to be statistically significant. Clinicians need to be sensitized about the utility and limitations of these indices and rationalize the need for red cell and platelet transfusions in dengue. Wolters Kluwer - Medknow 2023 2022-12-12 /pmc/articles/PMC10180782/ /pubmed/37188027 http://dx.doi.org/10.4103/ajts.AJTS_24_20 Text en Copyright: © 2022 Asian Journal of Transfusion Science https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Asha, J.
Baiju, Nithya M.
Innah, Susheela J.
Rafi, Aboobacker
John, Bins M.
Comparison of platelet indices in dengue fever patients based on platelet transfusion: A prospective observational study in a tertiary care center
title Comparison of platelet indices in dengue fever patients based on platelet transfusion: A prospective observational study in a tertiary care center
title_full Comparison of platelet indices in dengue fever patients based on platelet transfusion: A prospective observational study in a tertiary care center
title_fullStr Comparison of platelet indices in dengue fever patients based on platelet transfusion: A prospective observational study in a tertiary care center
title_full_unstemmed Comparison of platelet indices in dengue fever patients based on platelet transfusion: A prospective observational study in a tertiary care center
title_short Comparison of platelet indices in dengue fever patients based on platelet transfusion: A prospective observational study in a tertiary care center
title_sort comparison of platelet indices in dengue fever patients based on platelet transfusion: a prospective observational study in a tertiary care center
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180782/
https://www.ncbi.nlm.nih.gov/pubmed/37188027
http://dx.doi.org/10.4103/ajts.AJTS_24_20
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