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ABO incompatibility: A cause for neonatal alloimmune thrombocytopenia

ABO antibodies are naturally occurring antibodies. The ABO antibodies found in the Group O individuals include anti-A and anti-B. In Group O individuals, it tends to be predominantly immunoglobulins G (IgG), although immunoglobulins M and IgA components are also present. Infants of Group O mothers a...

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Autores principales: Shah, Ripal J., Harimoorthy, V., Khatwani, Geeta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180803/
https://www.ncbi.nlm.nih.gov/pubmed/37188011
http://dx.doi.org/10.4103/ajts.ajts_194_20
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author Shah, Ripal J.
Harimoorthy, V.
Khatwani, Geeta
author_facet Shah, Ripal J.
Harimoorthy, V.
Khatwani, Geeta
author_sort Shah, Ripal J.
collection PubMed
description ABO antibodies are naturally occurring antibodies. The ABO antibodies found in the Group O individuals include anti-A and anti-B. In Group O individuals, it tends to be predominantly immunoglobulins G (IgG), although immunoglobulins M and IgA components are also present. Infants of Group O mothers are at higher risk for hemolytic disease of the fetus and new-born than those born to mothers with Group A or B because IgG readily cross the placenta. At the same time, abnormal high concentration of ABO antibody in mother can lead to destruction of platelets in neonates and leads to development of neonatal alloimmune thrombocytopenia as human platelets carry detectable quantities of A and B blood group antigens on their surface. Proper and early diagnosis combined with treatment with intravenous immunoglobulins or transfusion with compatible platelets, may be from mother, can save the neonate from bleeding episodes.
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spelling pubmed-101808032023-05-13 ABO incompatibility: A cause for neonatal alloimmune thrombocytopenia Shah, Ripal J. Harimoorthy, V. Khatwani, Geeta Asian J Transfus Sci Case Report ABO antibodies are naturally occurring antibodies. The ABO antibodies found in the Group O individuals include anti-A and anti-B. In Group O individuals, it tends to be predominantly immunoglobulins G (IgG), although immunoglobulins M and IgA components are also present. Infants of Group O mothers are at higher risk for hemolytic disease of the fetus and new-born than those born to mothers with Group A or B because IgG readily cross the placenta. At the same time, abnormal high concentration of ABO antibody in mother can lead to destruction of platelets in neonates and leads to development of neonatal alloimmune thrombocytopenia as human platelets carry detectable quantities of A and B blood group antigens on their surface. Proper and early diagnosis combined with treatment with intravenous immunoglobulins or transfusion with compatible platelets, may be from mother, can save the neonate from bleeding episodes. Wolters Kluwer - Medknow 2023 2022-12-12 /pmc/articles/PMC10180803/ /pubmed/37188011 http://dx.doi.org/10.4103/ajts.ajts_194_20 Text en Copyright: © 2022 Asian Journal of Transfusion Science https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Shah, Ripal J.
Harimoorthy, V.
Khatwani, Geeta
ABO incompatibility: A cause for neonatal alloimmune thrombocytopenia
title ABO incompatibility: A cause for neonatal alloimmune thrombocytopenia
title_full ABO incompatibility: A cause for neonatal alloimmune thrombocytopenia
title_fullStr ABO incompatibility: A cause for neonatal alloimmune thrombocytopenia
title_full_unstemmed ABO incompatibility: A cause for neonatal alloimmune thrombocytopenia
title_short ABO incompatibility: A cause for neonatal alloimmune thrombocytopenia
title_sort abo incompatibility: a cause for neonatal alloimmune thrombocytopenia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180803/
https://www.ncbi.nlm.nih.gov/pubmed/37188011
http://dx.doi.org/10.4103/ajts.ajts_194_20
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