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Gut Immunobiosis and Biomodulators

The human gastrointestinal (GI) tract hosts complex and dynamic populations of microorganisms (gut microbiota) in advantageous symbiosis with the host organism through sophisticated molecular cross-talk. The balance and diversification within microbial communities (eubiosis) are crucial for the immu...

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Autores principales: Miniello, Vito Leonardo, Miniello, Andrea, Ficele, Laura, Skublewska-D’Elia, Aleksandra, Dargenio, Vanessa Nadia, Cristofori, Fernanda, Francavilla, Ruggiero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180914/
https://www.ncbi.nlm.nih.gov/pubmed/37432248
http://dx.doi.org/10.3390/nu15092114
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author Miniello, Vito Leonardo
Miniello, Andrea
Ficele, Laura
Skublewska-D’Elia, Aleksandra
Dargenio, Vanessa Nadia
Cristofori, Fernanda
Francavilla, Ruggiero
author_facet Miniello, Vito Leonardo
Miniello, Andrea
Ficele, Laura
Skublewska-D’Elia, Aleksandra
Dargenio, Vanessa Nadia
Cristofori, Fernanda
Francavilla, Ruggiero
author_sort Miniello, Vito Leonardo
collection PubMed
description The human gastrointestinal (GI) tract hosts complex and dynamic populations of microorganisms (gut microbiota) in advantageous symbiosis with the host organism through sophisticated molecular cross-talk. The balance and diversification within microbial communities (eubiosis) are crucial for the immune and metabolic homeostasis of the host, as well as for inhibiting pathogen penetration. In contrast, compositional dysregulation of the microbiota (dysbiosis) is blamed for the determinism of numerous diseases. Although further advances in the so-called ‘omics’ disciplines are needed, dietary manipulation of the gut microbial ecosystem through biomodulators (prebiotics, probiotics, symbionts, and postbiotics) represents an intriguing target to stabilize and/or restore eubiosis. Recently, new approaches have been developed for the production of infant formulas supplemented with prebiotics (human milk oligosaccharides [HMOs], galacto-oligosaccharides [GOS], fructo-oligosaccharides [FOS]), probiotics, and postbiotics to obtain formulas that are nutritionally and biologically equivalent to human milk (closer to the reference).
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spelling pubmed-101809142023-05-13 Gut Immunobiosis and Biomodulators Miniello, Vito Leonardo Miniello, Andrea Ficele, Laura Skublewska-D’Elia, Aleksandra Dargenio, Vanessa Nadia Cristofori, Fernanda Francavilla, Ruggiero Nutrients Review The human gastrointestinal (GI) tract hosts complex and dynamic populations of microorganisms (gut microbiota) in advantageous symbiosis with the host organism through sophisticated molecular cross-talk. The balance and diversification within microbial communities (eubiosis) are crucial for the immune and metabolic homeostasis of the host, as well as for inhibiting pathogen penetration. In contrast, compositional dysregulation of the microbiota (dysbiosis) is blamed for the determinism of numerous diseases. Although further advances in the so-called ‘omics’ disciplines are needed, dietary manipulation of the gut microbial ecosystem through biomodulators (prebiotics, probiotics, symbionts, and postbiotics) represents an intriguing target to stabilize and/or restore eubiosis. Recently, new approaches have been developed for the production of infant formulas supplemented with prebiotics (human milk oligosaccharides [HMOs], galacto-oligosaccharides [GOS], fructo-oligosaccharides [FOS]), probiotics, and postbiotics to obtain formulas that are nutritionally and biologically equivalent to human milk (closer to the reference). MDPI 2023-04-28 /pmc/articles/PMC10180914/ /pubmed/37432248 http://dx.doi.org/10.3390/nu15092114 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Miniello, Vito Leonardo
Miniello, Andrea
Ficele, Laura
Skublewska-D’Elia, Aleksandra
Dargenio, Vanessa Nadia
Cristofori, Fernanda
Francavilla, Ruggiero
Gut Immunobiosis and Biomodulators
title Gut Immunobiosis and Biomodulators
title_full Gut Immunobiosis and Biomodulators
title_fullStr Gut Immunobiosis and Biomodulators
title_full_unstemmed Gut Immunobiosis and Biomodulators
title_short Gut Immunobiosis and Biomodulators
title_sort gut immunobiosis and biomodulators
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180914/
https://www.ncbi.nlm.nih.gov/pubmed/37432248
http://dx.doi.org/10.3390/nu15092114
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