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Membrane Lipids in Ultra-High-Risk Patients: Potential Predictive Biomarkers of Conversion to Psychosis

Alterations in membrane lipids are reported in schizophrenia. However, no conclusion can be drawn regarding the extended and predictive value of these alterations in persons at ultra-high risk of psychosis (UHR). Recent studies suggested that sterols’ impact on psychiatric disorders was underestimat...

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Autores principales: Frajerman, Ariel, Chaumette, Boris, Farabos, Dominique, Despres, Gaétan, Simonard, Christelle, Lamazière, Antonin, Krebs, Marie-Odile, Kebir, Oussama
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181001/
https://www.ncbi.nlm.nih.gov/pubmed/37432345
http://dx.doi.org/10.3390/nu15092215
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author Frajerman, Ariel
Chaumette, Boris
Farabos, Dominique
Despres, Gaétan
Simonard, Christelle
Lamazière, Antonin
Krebs, Marie-Odile
Kebir, Oussama
author_facet Frajerman, Ariel
Chaumette, Boris
Farabos, Dominique
Despres, Gaétan
Simonard, Christelle
Lamazière, Antonin
Krebs, Marie-Odile
Kebir, Oussama
author_sort Frajerman, Ariel
collection PubMed
description Alterations in membrane lipids are reported in schizophrenia. However, no conclusion can be drawn regarding the extended and predictive value of these alterations in persons at ultra-high risk of psychosis (UHR). Recent studies suggested that sterols’ impact on psychiatric disorders was underestimated. Here, we simultaneously explored sterols, fatty acids (FA), and phospholipids (PL) in UHR persons for the first time. We analysed erythrocyte membrane lipids in 61 UHR persons, including 29 who later converted to psychosis (UHR-C) and 32 who did not (UHC-NC). We used gas chromatography for FA and liquid chromatography tandem with mass spectrometry for sterols and phospholipids. Among UHR individuals, elevated baseline membrane linoleic acid level was associated with conversion to psychosis (26.1% vs. 60.5%, p = 0.02). Combining sterols, FA, and PL membrane composition improved the prediction of psychosis onset (AUC = 0.73). This is the first report showing that membrane sterol participates, with other membrane lipids, in modulating the risk of psychosis. It suggests that membrane lipids could be used as biomarkers for personalised medicine in UHR patients.
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spelling pubmed-101810012023-05-13 Membrane Lipids in Ultra-High-Risk Patients: Potential Predictive Biomarkers of Conversion to Psychosis Frajerman, Ariel Chaumette, Boris Farabos, Dominique Despres, Gaétan Simonard, Christelle Lamazière, Antonin Krebs, Marie-Odile Kebir, Oussama Nutrients Article Alterations in membrane lipids are reported in schizophrenia. However, no conclusion can be drawn regarding the extended and predictive value of these alterations in persons at ultra-high risk of psychosis (UHR). Recent studies suggested that sterols’ impact on psychiatric disorders was underestimated. Here, we simultaneously explored sterols, fatty acids (FA), and phospholipids (PL) in UHR persons for the first time. We analysed erythrocyte membrane lipids in 61 UHR persons, including 29 who later converted to psychosis (UHR-C) and 32 who did not (UHC-NC). We used gas chromatography for FA and liquid chromatography tandem with mass spectrometry for sterols and phospholipids. Among UHR individuals, elevated baseline membrane linoleic acid level was associated with conversion to psychosis (26.1% vs. 60.5%, p = 0.02). Combining sterols, FA, and PL membrane composition improved the prediction of psychosis onset (AUC = 0.73). This is the first report showing that membrane sterol participates, with other membrane lipids, in modulating the risk of psychosis. It suggests that membrane lipids could be used as biomarkers for personalised medicine in UHR patients. MDPI 2023-05-07 /pmc/articles/PMC10181001/ /pubmed/37432345 http://dx.doi.org/10.3390/nu15092215 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Frajerman, Ariel
Chaumette, Boris
Farabos, Dominique
Despres, Gaétan
Simonard, Christelle
Lamazière, Antonin
Krebs, Marie-Odile
Kebir, Oussama
Membrane Lipids in Ultra-High-Risk Patients: Potential Predictive Biomarkers of Conversion to Psychosis
title Membrane Lipids in Ultra-High-Risk Patients: Potential Predictive Biomarkers of Conversion to Psychosis
title_full Membrane Lipids in Ultra-High-Risk Patients: Potential Predictive Biomarkers of Conversion to Psychosis
title_fullStr Membrane Lipids in Ultra-High-Risk Patients: Potential Predictive Biomarkers of Conversion to Psychosis
title_full_unstemmed Membrane Lipids in Ultra-High-Risk Patients: Potential Predictive Biomarkers of Conversion to Psychosis
title_short Membrane Lipids in Ultra-High-Risk Patients: Potential Predictive Biomarkers of Conversion to Psychosis
title_sort membrane lipids in ultra-high-risk patients: potential predictive biomarkers of conversion to psychosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181001/
https://www.ncbi.nlm.nih.gov/pubmed/37432345
http://dx.doi.org/10.3390/nu15092215
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