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Pharmacological Activity of Flavonoid Quercetin and Its Therapeutic Potential in Testicular Injury

Quercetin is a natural flavonoid widely found in natural fruits and vegetables. Recent studies have shown that quercetin mediates multiple beneficial effects in a variety of organ damage and diseases, and is considered a healthcare supplement with health-promoting potential. Male infertility is a ma...

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Detalles Bibliográficos
Autores principales: Zhang, Xiaohui, Tang, Yufeng, Lu, Guangping, Gu, Junlian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181015/
https://www.ncbi.nlm.nih.gov/pubmed/37432408
http://dx.doi.org/10.3390/nu15092231
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author Zhang, Xiaohui
Tang, Yufeng
Lu, Guangping
Gu, Junlian
author_facet Zhang, Xiaohui
Tang, Yufeng
Lu, Guangping
Gu, Junlian
author_sort Zhang, Xiaohui
collection PubMed
description Quercetin is a natural flavonoid widely found in natural fruits and vegetables. Recent studies have shown that quercetin mediates multiple beneficial effects in a variety of organ damage and diseases, and is considered a healthcare supplement with health-promoting potential. Male infertility is a major health concern, and testicular damage from multiple causes is an important etiology. Previous studies have shown that quercetin has a protective effect on reproductive function. This may be related to the antioxidant, anti-inflammatory, and anti-apoptotic biological activities of quercetin. Therefore, this paper reviews the mechanisms by which quercetin exerts its pharmacological activity and its role in testicular damage induced by various etiologies. In addition, this paper compiles the application of quercetin in clinical trials, demonstrating its practical effects in regulating blood pressure and inhibiting cellular senescence in human patients. However, more in-depth experimental studies and clinical trials are needed to confirm the true value of quercetin for the prevention and protection against testicular injury.
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spelling pubmed-101810152023-05-13 Pharmacological Activity of Flavonoid Quercetin and Its Therapeutic Potential in Testicular Injury Zhang, Xiaohui Tang, Yufeng Lu, Guangping Gu, Junlian Nutrients Review Quercetin is a natural flavonoid widely found in natural fruits and vegetables. Recent studies have shown that quercetin mediates multiple beneficial effects in a variety of organ damage and diseases, and is considered a healthcare supplement with health-promoting potential. Male infertility is a major health concern, and testicular damage from multiple causes is an important etiology. Previous studies have shown that quercetin has a protective effect on reproductive function. This may be related to the antioxidant, anti-inflammatory, and anti-apoptotic biological activities of quercetin. Therefore, this paper reviews the mechanisms by which quercetin exerts its pharmacological activity and its role in testicular damage induced by various etiologies. In addition, this paper compiles the application of quercetin in clinical trials, demonstrating its practical effects in regulating blood pressure and inhibiting cellular senescence in human patients. However, more in-depth experimental studies and clinical trials are needed to confirm the true value of quercetin for the prevention and protection against testicular injury. MDPI 2023-05-08 /pmc/articles/PMC10181015/ /pubmed/37432408 http://dx.doi.org/10.3390/nu15092231 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhang, Xiaohui
Tang, Yufeng
Lu, Guangping
Gu, Junlian
Pharmacological Activity of Flavonoid Quercetin and Its Therapeutic Potential in Testicular Injury
title Pharmacological Activity of Flavonoid Quercetin and Its Therapeutic Potential in Testicular Injury
title_full Pharmacological Activity of Flavonoid Quercetin and Its Therapeutic Potential in Testicular Injury
title_fullStr Pharmacological Activity of Flavonoid Quercetin and Its Therapeutic Potential in Testicular Injury
title_full_unstemmed Pharmacological Activity of Flavonoid Quercetin and Its Therapeutic Potential in Testicular Injury
title_short Pharmacological Activity of Flavonoid Quercetin and Its Therapeutic Potential in Testicular Injury
title_sort pharmacological activity of flavonoid quercetin and its therapeutic potential in testicular injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181015/
https://www.ncbi.nlm.nih.gov/pubmed/37432408
http://dx.doi.org/10.3390/nu15092231
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