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Late, but Not Early, Night Sleep Loss Compromises Neuroendocrine Appetite Regulation and the Desire for Food

Objective: There is evidence that reduced sleep duration increases hunger, appetite, and food intake, leading to metabolic diseases, such as type 2 diabetes and obesity. However, the impact of sleep timing, irrespective of its duration and on the regulation of hunger and appetite, is less clear. We...

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Autores principales: Meyhöfer, Svenja, Chamorro, Rodrigo, Hallschmid, Manfred, Spyra, Denisa, Klinsmann, Nelli, Schultes, Bernd, Lehnert, Hendrik, Meyhöfer, Sebastian M., Wilms, Britta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181094/
https://www.ncbi.nlm.nih.gov/pubmed/37432152
http://dx.doi.org/10.3390/nu15092035
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author Meyhöfer, Svenja
Chamorro, Rodrigo
Hallschmid, Manfred
Spyra, Denisa
Klinsmann, Nelli
Schultes, Bernd
Lehnert, Hendrik
Meyhöfer, Sebastian M.
Wilms, Britta
author_facet Meyhöfer, Svenja
Chamorro, Rodrigo
Hallschmid, Manfred
Spyra, Denisa
Klinsmann, Nelli
Schultes, Bernd
Lehnert, Hendrik
Meyhöfer, Sebastian M.
Wilms, Britta
author_sort Meyhöfer, Svenja
collection PubMed
description Objective: There is evidence that reduced sleep duration increases hunger, appetite, and food intake, leading to metabolic diseases, such as type 2 diabetes and obesity. However, the impact of sleep timing, irrespective of its duration and on the regulation of hunger and appetite, is less clear. We aimed to evaluate the impact of sleep loss during the late vs. early part of the night on the regulation of hunger, appetite, and desire for food. Methods: Fifteen normal-weight ([mean ± SEM] body-mass index: 23.3 ± 0.4 kg/m(2)) healthy men were studied in a randomized, balanced, crossover design, including two conditions of sleep loss, i.e., 4 h sleep during the first night-half (‘late-night sleep loss’), 4 h sleep during the second night-half (‘early-night sleep loss’), and a control condition with 8h sleep (‘regular sleep’), respectively. Feelings of hunger and appetite were assessed through visual analogue scales, and plasma ghrelin and leptin were measured from blood samples taken before, during, and after night-time sleep. Results: Ghrelin and feelings of hunger and appetite, as well as the desire for food, were increased after ‘late-night sleep loss’, but not ‘early-night sleep loss’, whereas leptin remained unaffected by the timing of sleep loss. Conclusions: Our data indicate that timing of sleep restriction modulates the effects of acute sleep loss on ghrelin and appetite regulation in healthy men. ‘Late-night sleep loss’ might be a risk factor for metabolic diseases, such as obesity and type 2 diabetes. Thereby, our findings highlight the metabolic relevance of chronobiological sleep timing.
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spelling pubmed-101810942023-05-13 Late, but Not Early, Night Sleep Loss Compromises Neuroendocrine Appetite Regulation and the Desire for Food Meyhöfer, Svenja Chamorro, Rodrigo Hallschmid, Manfred Spyra, Denisa Klinsmann, Nelli Schultes, Bernd Lehnert, Hendrik Meyhöfer, Sebastian M. Wilms, Britta Nutrients Article Objective: There is evidence that reduced sleep duration increases hunger, appetite, and food intake, leading to metabolic diseases, such as type 2 diabetes and obesity. However, the impact of sleep timing, irrespective of its duration and on the regulation of hunger and appetite, is less clear. We aimed to evaluate the impact of sleep loss during the late vs. early part of the night on the regulation of hunger, appetite, and desire for food. Methods: Fifteen normal-weight ([mean ± SEM] body-mass index: 23.3 ± 0.4 kg/m(2)) healthy men were studied in a randomized, balanced, crossover design, including two conditions of sleep loss, i.e., 4 h sleep during the first night-half (‘late-night sleep loss’), 4 h sleep during the second night-half (‘early-night sleep loss’), and a control condition with 8h sleep (‘regular sleep’), respectively. Feelings of hunger and appetite were assessed through visual analogue scales, and plasma ghrelin and leptin were measured from blood samples taken before, during, and after night-time sleep. Results: Ghrelin and feelings of hunger and appetite, as well as the desire for food, were increased after ‘late-night sleep loss’, but not ‘early-night sleep loss’, whereas leptin remained unaffected by the timing of sleep loss. Conclusions: Our data indicate that timing of sleep restriction modulates the effects of acute sleep loss on ghrelin and appetite regulation in healthy men. ‘Late-night sleep loss’ might be a risk factor for metabolic diseases, such as obesity and type 2 diabetes. Thereby, our findings highlight the metabolic relevance of chronobiological sleep timing. MDPI 2023-04-23 /pmc/articles/PMC10181094/ /pubmed/37432152 http://dx.doi.org/10.3390/nu15092035 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Meyhöfer, Svenja
Chamorro, Rodrigo
Hallschmid, Manfred
Spyra, Denisa
Klinsmann, Nelli
Schultes, Bernd
Lehnert, Hendrik
Meyhöfer, Sebastian M.
Wilms, Britta
Late, but Not Early, Night Sleep Loss Compromises Neuroendocrine Appetite Regulation and the Desire for Food
title Late, but Not Early, Night Sleep Loss Compromises Neuroendocrine Appetite Regulation and the Desire for Food
title_full Late, but Not Early, Night Sleep Loss Compromises Neuroendocrine Appetite Regulation and the Desire for Food
title_fullStr Late, but Not Early, Night Sleep Loss Compromises Neuroendocrine Appetite Regulation and the Desire for Food
title_full_unstemmed Late, but Not Early, Night Sleep Loss Compromises Neuroendocrine Appetite Regulation and the Desire for Food
title_short Late, but Not Early, Night Sleep Loss Compromises Neuroendocrine Appetite Regulation and the Desire for Food
title_sort late, but not early, night sleep loss compromises neuroendocrine appetite regulation and the desire for food
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181094/
https://www.ncbi.nlm.nih.gov/pubmed/37432152
http://dx.doi.org/10.3390/nu15092035
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