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Proposal to Screen for Zinc and Selenium in Patients with IgA Deficiency

The increase in life expectancy can be a consequence of the world’s socioeconomic, sanitary and nutritional conditions. Some studies have demonstrated that individuals with a satisfactory diet variety score present a lower risk of malnutrition and better health status. Zinc and selenium are importan...

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Autores principales: Abu Jamra, Soraya Regina, Komatsu, Camila Gomes, Barbosa, Fernando, Roxo-Junior, Persio, Navarro, Anderson Marliere
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181106/
https://www.ncbi.nlm.nih.gov/pubmed/37432290
http://dx.doi.org/10.3390/nu15092145
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author Abu Jamra, Soraya Regina
Komatsu, Camila Gomes
Barbosa, Fernando
Roxo-Junior, Persio
Navarro, Anderson Marliere
author_facet Abu Jamra, Soraya Regina
Komatsu, Camila Gomes
Barbosa, Fernando
Roxo-Junior, Persio
Navarro, Anderson Marliere
author_sort Abu Jamra, Soraya Regina
collection PubMed
description The increase in life expectancy can be a consequence of the world’s socioeconomic, sanitary and nutritional conditions. Some studies have demonstrated that individuals with a satisfactory diet variety score present a lower risk of malnutrition and better health status. Zinc and selenium are important micronutrients that play a role in many biochemical and physiological processes of the immune system. Deficient individuals can present both innate and adaptive immunity abnormalities and increased susceptibility to infections. Primary immunodeficiency diseases, also known as inborn errors of immunity, are genetic disorders classically characterized by an increased susceptibility to infection and/or dysregulation of a specific immunologic pathway. IgA deficiency (IgAD) is the most common primary antibody deficiency. This disease is defined as serum IgA levels lower than 7 mg/dL and normal IgG and IgM levels in individuals older than four years. Although many patients are asymptomatic, selected patients suffer from different clinical complications, such as pulmonary infections, allergies, autoimmune diseases, gastrointestinal disorders and malignancy. Knowing the nutritional status as well as the risk of zinc and selenium deficiency could be helpful for the management of IgAD patients. Objectives: to investigate the anthropometric, biochemical, and nutritional profiles and the status of zinc and selenium in patients with IgAD. Methods: in this descriptive study, we screened 16 IgAD patients for anthropometric and dietary data, biochemical evaluation and determination of plasma and erythrocyte levels of zinc and selenium. Results: dietary intake of zinc and selenium was adequate in 75% and 86% of the patients, respectively. These results were consistent with the plasma levels (adequate levels of zinc in all patients and selenium in 50% of children, 25% of adolescents and 100% of adults). However, erythrocyte levels were low for both micronutrients (deficiency for both in 100% of children, 75% of adolescents and 25% of adults). Conclusion: our results highlight the elevated prevalence of erythrocyte zinc and selenium deficiency in patients with IgAD, and the need for investigation of these micronutrients in their follow-up.
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spelling pubmed-101811062023-05-13 Proposal to Screen for Zinc and Selenium in Patients with IgA Deficiency Abu Jamra, Soraya Regina Komatsu, Camila Gomes Barbosa, Fernando Roxo-Junior, Persio Navarro, Anderson Marliere Nutrients Article The increase in life expectancy can be a consequence of the world’s socioeconomic, sanitary and nutritional conditions. Some studies have demonstrated that individuals with a satisfactory diet variety score present a lower risk of malnutrition and better health status. Zinc and selenium are important micronutrients that play a role in many biochemical and physiological processes of the immune system. Deficient individuals can present both innate and adaptive immunity abnormalities and increased susceptibility to infections. Primary immunodeficiency diseases, also known as inborn errors of immunity, are genetic disorders classically characterized by an increased susceptibility to infection and/or dysregulation of a specific immunologic pathway. IgA deficiency (IgAD) is the most common primary antibody deficiency. This disease is defined as serum IgA levels lower than 7 mg/dL and normal IgG and IgM levels in individuals older than four years. Although many patients are asymptomatic, selected patients suffer from different clinical complications, such as pulmonary infections, allergies, autoimmune diseases, gastrointestinal disorders and malignancy. Knowing the nutritional status as well as the risk of zinc and selenium deficiency could be helpful for the management of IgAD patients. Objectives: to investigate the anthropometric, biochemical, and nutritional profiles and the status of zinc and selenium in patients with IgAD. Methods: in this descriptive study, we screened 16 IgAD patients for anthropometric and dietary data, biochemical evaluation and determination of plasma and erythrocyte levels of zinc and selenium. Results: dietary intake of zinc and selenium was adequate in 75% and 86% of the patients, respectively. These results were consistent with the plasma levels (adequate levels of zinc in all patients and selenium in 50% of children, 25% of adolescents and 100% of adults). However, erythrocyte levels were low for both micronutrients (deficiency for both in 100% of children, 75% of adolescents and 25% of adults). Conclusion: our results highlight the elevated prevalence of erythrocyte zinc and selenium deficiency in patients with IgAD, and the need for investigation of these micronutrients in their follow-up. MDPI 2023-04-29 /pmc/articles/PMC10181106/ /pubmed/37432290 http://dx.doi.org/10.3390/nu15092145 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Abu Jamra, Soraya Regina
Komatsu, Camila Gomes
Barbosa, Fernando
Roxo-Junior, Persio
Navarro, Anderson Marliere
Proposal to Screen for Zinc and Selenium in Patients with IgA Deficiency
title Proposal to Screen for Zinc and Selenium in Patients with IgA Deficiency
title_full Proposal to Screen for Zinc and Selenium in Patients with IgA Deficiency
title_fullStr Proposal to Screen for Zinc and Selenium in Patients with IgA Deficiency
title_full_unstemmed Proposal to Screen for Zinc and Selenium in Patients with IgA Deficiency
title_short Proposal to Screen for Zinc and Selenium in Patients with IgA Deficiency
title_sort proposal to screen for zinc and selenium in patients with iga deficiency
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181106/
https://www.ncbi.nlm.nih.gov/pubmed/37432290
http://dx.doi.org/10.3390/nu15092145
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