Cargando…
Vitamin D Levels in the Pre- and Post-COVID-19 Pandemic Periods and Related Confinement at Pediatric Age
Coronavirus disease 2019 (COVID-19) restrictions have been correlated with vitamin D deficiency in children, but some uncertainties remain. We retrospectively studied vitamin 25-(OH) D blood levels in 2182 Italian children/adolescents hospitalized for various chronic diseases in the year before (n =...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181113/ https://www.ncbi.nlm.nih.gov/pubmed/37432239 http://dx.doi.org/10.3390/nu15092089 |
_version_ | 1785041495472996352 |
---|---|
author | Mosca, Caterina Colucci, Angelo Savoia, Fabio Calì, Camilla Del Bene, Margherita Ranucci, Giusy Maglione, Antonio Pepe, Angela Morelli, Annalisa Vajro, Pietro Mandato, Claudia |
author_facet | Mosca, Caterina Colucci, Angelo Savoia, Fabio Calì, Camilla Del Bene, Margherita Ranucci, Giusy Maglione, Antonio Pepe, Angela Morelli, Annalisa Vajro, Pietro Mandato, Claudia |
author_sort | Mosca, Caterina |
collection | PubMed |
description | Coronavirus disease 2019 (COVID-19) restrictions have been correlated with vitamin D deficiency in children, but some uncertainties remain. We retrospectively studied vitamin 25-(OH) D blood levels in 2182 Italian children/adolescents hospitalized for various chronic diseases in the year before (n = 1052) and after (n = 1130) the nationwide lockdown. The type of underlying disease, gender, and mean age (91 ± 55 and 91 ± 61 months, respectively) of patients included in the two periods were comparable. Although mean levels were the same (p = 0.24), deficiency status affected a significantly higher number of subjects during the lockdown period than in the pre-COVID period (p = 0.03), particularly in summer (p = 0.02), and there was also a smoothing of seasonal variations in vitamin D levels. Particularly at risk were males (OR = 1.22; p = 0.03), the 1–5 year age group (OR = 1.57; p < 0.01) and the 6–12 year age group (OR = 1.30; p = 0.04). Infants appeared not to be affected (p = 1.00). In the post-COVID period, the risk of vitamin D deficiency was unchanged in disease-specific groups. However, the proportion of deficiency or severe deficiency differed significantly in the subgroup with endocrinopathy (higher; Chi-square p = 0.04), and with respiratory problems and obesity (lower; Chi-square p = 0.01 and p < 0.01, respectively). Conflicting/opposite literature results advocate for further studies to clearly indicate the need for supplementation during possible future periods of confinement. |
format | Online Article Text |
id | pubmed-10181113 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101811132023-05-13 Vitamin D Levels in the Pre- and Post-COVID-19 Pandemic Periods and Related Confinement at Pediatric Age Mosca, Caterina Colucci, Angelo Savoia, Fabio Calì, Camilla Del Bene, Margherita Ranucci, Giusy Maglione, Antonio Pepe, Angela Morelli, Annalisa Vajro, Pietro Mandato, Claudia Nutrients Article Coronavirus disease 2019 (COVID-19) restrictions have been correlated with vitamin D deficiency in children, but some uncertainties remain. We retrospectively studied vitamin 25-(OH) D blood levels in 2182 Italian children/adolescents hospitalized for various chronic diseases in the year before (n = 1052) and after (n = 1130) the nationwide lockdown. The type of underlying disease, gender, and mean age (91 ± 55 and 91 ± 61 months, respectively) of patients included in the two periods were comparable. Although mean levels were the same (p = 0.24), deficiency status affected a significantly higher number of subjects during the lockdown period than in the pre-COVID period (p = 0.03), particularly in summer (p = 0.02), and there was also a smoothing of seasonal variations in vitamin D levels. Particularly at risk were males (OR = 1.22; p = 0.03), the 1–5 year age group (OR = 1.57; p < 0.01) and the 6–12 year age group (OR = 1.30; p = 0.04). Infants appeared not to be affected (p = 1.00). In the post-COVID period, the risk of vitamin D deficiency was unchanged in disease-specific groups. However, the proportion of deficiency or severe deficiency differed significantly in the subgroup with endocrinopathy (higher; Chi-square p = 0.04), and with respiratory problems and obesity (lower; Chi-square p = 0.01 and p < 0.01, respectively). Conflicting/opposite literature results advocate for further studies to clearly indicate the need for supplementation during possible future periods of confinement. MDPI 2023-04-26 /pmc/articles/PMC10181113/ /pubmed/37432239 http://dx.doi.org/10.3390/nu15092089 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Mosca, Caterina Colucci, Angelo Savoia, Fabio Calì, Camilla Del Bene, Margherita Ranucci, Giusy Maglione, Antonio Pepe, Angela Morelli, Annalisa Vajro, Pietro Mandato, Claudia Vitamin D Levels in the Pre- and Post-COVID-19 Pandemic Periods and Related Confinement at Pediatric Age |
title | Vitamin D Levels in the Pre- and Post-COVID-19 Pandemic Periods and Related Confinement at Pediatric Age |
title_full | Vitamin D Levels in the Pre- and Post-COVID-19 Pandemic Periods and Related Confinement at Pediatric Age |
title_fullStr | Vitamin D Levels in the Pre- and Post-COVID-19 Pandemic Periods and Related Confinement at Pediatric Age |
title_full_unstemmed | Vitamin D Levels in the Pre- and Post-COVID-19 Pandemic Periods and Related Confinement at Pediatric Age |
title_short | Vitamin D Levels in the Pre- and Post-COVID-19 Pandemic Periods and Related Confinement at Pediatric Age |
title_sort | vitamin d levels in the pre- and post-covid-19 pandemic periods and related confinement at pediatric age |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181113/ https://www.ncbi.nlm.nih.gov/pubmed/37432239 http://dx.doi.org/10.3390/nu15092089 |
work_keys_str_mv | AT moscacaterina vitamindlevelsinthepreandpostcovid19pandemicperiodsandrelatedconfinementatpediatricage AT colucciangelo vitamindlevelsinthepreandpostcovid19pandemicperiodsandrelatedconfinementatpediatricage AT savoiafabio vitamindlevelsinthepreandpostcovid19pandemicperiodsandrelatedconfinementatpediatricage AT calicamilla vitamindlevelsinthepreandpostcovid19pandemicperiodsandrelatedconfinementatpediatricage AT delbenemargherita vitamindlevelsinthepreandpostcovid19pandemicperiodsandrelatedconfinementatpediatricage AT ranuccigiusy vitamindlevelsinthepreandpostcovid19pandemicperiodsandrelatedconfinementatpediatricage AT maglioneantonio vitamindlevelsinthepreandpostcovid19pandemicperiodsandrelatedconfinementatpediatricage AT pepeangela vitamindlevelsinthepreandpostcovid19pandemicperiodsandrelatedconfinementatpediatricage AT morelliannalisa vitamindlevelsinthepreandpostcovid19pandemicperiodsandrelatedconfinementatpediatricage AT vajropietro vitamindlevelsinthepreandpostcovid19pandemicperiodsandrelatedconfinementatpediatricage AT mandatoclaudia vitamindlevelsinthepreandpostcovid19pandemicperiodsandrelatedconfinementatpediatricage |