Efficient cancer modeling through CRISPR-Cas9/HDR-based somatic precision gene editing in mice

CRISPR-Cas9 has been used successfully to introduce indels in somatic cells of rodents; however, precise editing of single nucleotides has been hampered by limitations of flexibility and efficiency. Here, we report technological modifications to the CRISPR-Cas9 vector system that now allows homology...

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Detalles Bibliográficos
Autores principales: Bu, Wen, Creighton, Chad J., Heavener, Kelsey S., Gutierrez, Carolina, Dou, Yongchao, Ku, Amy T., Zhang, Yiqun, Jiang, Weiyu, Urrutia, Jazmin, Jiang, Wen, Yue, Fei, Jia, Luyu, Ibrahim, Ahmed Atef, Zhang, Bing, Huang, Shixia, Li, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181191/
https://www.ncbi.nlm.nih.gov/pubmed/37172086
http://dx.doi.org/10.1126/sciadv.ade0059

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181191/
https://www.ncbi.nlm.nih.gov/pubmed/37172086
http://dx.doi.org/10.1126/sciadv.ade0059

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