TREM2 inhibition triggers antitumor cell activity of myeloid cells in glioblastoma

Triggering receptor expressed on myeloid cells 2 (TREM2) plays important roles in brain microglial function in neurodegenerative diseases, but the role of TREM2 in the GBM TME has not been examined. Here, we found that TREM2 is highly expressed in myeloid subsets, including macrophages and microglia...

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Detalles Bibliográficos
Autores principales: Sun, Rui, Han, Rowland, McCornack, Colin, Khan, Saad, Tabor, G. Travis, Chen, Yun, Hou, Jinchao, Jiang, Haowu, Schoch, Kathleen M., Mao, Diane D., Cleary, Ryan, Yang, Alicia, Liu, Qin, Luo, Jingqin, Petti, Allegra, Miller, Timothy M., Ulrich, Jason D., Holtzman, David M., Kim, Albert H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181199/
https://www.ncbi.nlm.nih.gov/pubmed/37172094
http://dx.doi.org/10.1126/sciadv.ade3559

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