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Numerical Approach to Simulate the Mechanical Behavior of Biodegradable Polymers during Erosion
Biodegradable polymers find applications in many market segments. The ability to meet mechanical requirements within a certain time range, after which it degrades and is naturally absorbed, can be used to produce short-term use products that can be easily disposable with less environmental impact. I...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181274/ https://www.ncbi.nlm.nih.gov/pubmed/37177128 http://dx.doi.org/10.3390/polym15091979 |
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author | Vieira, André F. C. Da Silva, Enio H. P. Ribeiro, Marcelo L. |
author_facet | Vieira, André F. C. Da Silva, Enio H. P. Ribeiro, Marcelo L. |
author_sort | Vieira, André F. C. |
collection | PubMed |
description | Biodegradable polymers find applications in many market segments. The ability to meet mechanical requirements within a certain time range, after which it degrades and is naturally absorbed, can be used to produce short-term use products that can be easily disposable with less environmental impact. In the segment of medical devices used in regenerative medicine, these materials are used to produce temporary implants that are naturally assimilated by the human body, avoiding a removal surgery. However, the design of these temporary devices still presents great challenges, namely in the verification of the main requirement: the lifetime of the device, associated with the progressive loss of mechanical properties, until its complete erosion and assimilation. Thus, in this study, a numerical approach is proposed to simulate the polymeric device’s mechanical behavior during its hydrolytic degradation by combining the hydrolysis kinetics, that depends on mechanical factors and promotes a decrease of molecular weight and consequent decrease of mechanical performance, and erosion, when molecular weight reaches a threshold value and the polymer becomes soluble and diffuses outward, resulting in mass loss and decreasing cross-sectional area, which also contributes to the mechanical performance reduction of the device. A phenomenological approach, using the combination of continuum-based hydrolytic damage for the evolution of mechanical properties that depends on the stress field and further removal of the degraded element (to simulate mass loss) was used. Both elastoplastic and hyperelastic constitutive models were applied on this study, where the material model parameters locally depend on the molecular weight. |
format | Online Article Text |
id | pubmed-10181274 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101812742023-05-13 Numerical Approach to Simulate the Mechanical Behavior of Biodegradable Polymers during Erosion Vieira, André F. C. Da Silva, Enio H. P. Ribeiro, Marcelo L. Polymers (Basel) Article Biodegradable polymers find applications in many market segments. The ability to meet mechanical requirements within a certain time range, after which it degrades and is naturally absorbed, can be used to produce short-term use products that can be easily disposable with less environmental impact. In the segment of medical devices used in regenerative medicine, these materials are used to produce temporary implants that are naturally assimilated by the human body, avoiding a removal surgery. However, the design of these temporary devices still presents great challenges, namely in the verification of the main requirement: the lifetime of the device, associated with the progressive loss of mechanical properties, until its complete erosion and assimilation. Thus, in this study, a numerical approach is proposed to simulate the polymeric device’s mechanical behavior during its hydrolytic degradation by combining the hydrolysis kinetics, that depends on mechanical factors and promotes a decrease of molecular weight and consequent decrease of mechanical performance, and erosion, when molecular weight reaches a threshold value and the polymer becomes soluble and diffuses outward, resulting in mass loss and decreasing cross-sectional area, which also contributes to the mechanical performance reduction of the device. A phenomenological approach, using the combination of continuum-based hydrolytic damage for the evolution of mechanical properties that depends on the stress field and further removal of the degraded element (to simulate mass loss) was used. Both elastoplastic and hyperelastic constitutive models were applied on this study, where the material model parameters locally depend on the molecular weight. MDPI 2023-04-22 /pmc/articles/PMC10181274/ /pubmed/37177128 http://dx.doi.org/10.3390/polym15091979 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Vieira, André F. C. Da Silva, Enio H. P. Ribeiro, Marcelo L. Numerical Approach to Simulate the Mechanical Behavior of Biodegradable Polymers during Erosion |
title | Numerical Approach to Simulate the Mechanical Behavior of Biodegradable Polymers during Erosion |
title_full | Numerical Approach to Simulate the Mechanical Behavior of Biodegradable Polymers during Erosion |
title_fullStr | Numerical Approach to Simulate the Mechanical Behavior of Biodegradable Polymers during Erosion |
title_full_unstemmed | Numerical Approach to Simulate the Mechanical Behavior of Biodegradable Polymers during Erosion |
title_short | Numerical Approach to Simulate the Mechanical Behavior of Biodegradable Polymers during Erosion |
title_sort | numerical approach to simulate the mechanical behavior of biodegradable polymers during erosion |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181274/ https://www.ncbi.nlm.nih.gov/pubmed/37177128 http://dx.doi.org/10.3390/polym15091979 |
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