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Vitamin D Supplementation and Vitamin D Status during Pregnancy and the Risk of Congenital Anomalies—A Systematic Review and Meta-Analysis

Maternal dietary factors have been suggested as possible contributing influences for congenital anomalies (CAs). We aimed to assess the association between vitamin D supplementation or vitamin D status (s-25OHD) during pregnancy and CAs in the offspring. A comprehensive literature search was conduct...

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Autores principales: Walker, Karen Christina, Thorsteinsdottir, Fanney, Christesen, Henrik Thybo, Hjortdal, Vibeke Elisabeth, Heitmann, Berit Lilienthal, Specht, Ina Olmer, Händel, Mina Nicole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181330/
https://www.ncbi.nlm.nih.gov/pubmed/37432271
http://dx.doi.org/10.3390/nu15092125
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author Walker, Karen Christina
Thorsteinsdottir, Fanney
Christesen, Henrik Thybo
Hjortdal, Vibeke Elisabeth
Heitmann, Berit Lilienthal
Specht, Ina Olmer
Händel, Mina Nicole
author_facet Walker, Karen Christina
Thorsteinsdottir, Fanney
Christesen, Henrik Thybo
Hjortdal, Vibeke Elisabeth
Heitmann, Berit Lilienthal
Specht, Ina Olmer
Händel, Mina Nicole
author_sort Walker, Karen Christina
collection PubMed
description Maternal dietary factors have been suggested as possible contributing influences for congenital anomalies (CAs). We aimed to assess the association between vitamin D supplementation or vitamin D status (s-25OHD) during pregnancy and CAs in the offspring. A comprehensive literature search was conducted in the three electronic databases: PubMed, Embase, and Cochrane Library. Included studies were critically appraised using appropriate tools (risk of bias 2, ROBINS-I). A protocol was registered in the International Prospective Register of Systematic Reviews (CRD42019127131). A meta-analysis of four randomised controlled trials (RCTs) including 3931 participants showed no effect of vitamin D supplementation on CAs, a relative risk of 0.76 (95% CI 0.45; 1.30), with moderate certainty in the effect estimates by GRADE assessment. Of the nine identified observational studies, six were excluded due to a critical risk of bias in accordance with ROBINS-I. Among the included observational studies, two studies found no association, whereas one case-control study identified an association between s-25OHD < 20 nmol/L and neural tube defects, with an adjusted odds ratio of 2.34 (95% CI: 1.07; 5.07). Interpretation of the results should be cautious given the low prevalence of CAs, RCTs with onset of supplementation after organogenesis, and low-quality observational studies.
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spelling pubmed-101813302023-05-13 Vitamin D Supplementation and Vitamin D Status during Pregnancy and the Risk of Congenital Anomalies—A Systematic Review and Meta-Analysis Walker, Karen Christina Thorsteinsdottir, Fanney Christesen, Henrik Thybo Hjortdal, Vibeke Elisabeth Heitmann, Berit Lilienthal Specht, Ina Olmer Händel, Mina Nicole Nutrients Systematic Review Maternal dietary factors have been suggested as possible contributing influences for congenital anomalies (CAs). We aimed to assess the association between vitamin D supplementation or vitamin D status (s-25OHD) during pregnancy and CAs in the offspring. A comprehensive literature search was conducted in the three electronic databases: PubMed, Embase, and Cochrane Library. Included studies were critically appraised using appropriate tools (risk of bias 2, ROBINS-I). A protocol was registered in the International Prospective Register of Systematic Reviews (CRD42019127131). A meta-analysis of four randomised controlled trials (RCTs) including 3931 participants showed no effect of vitamin D supplementation on CAs, a relative risk of 0.76 (95% CI 0.45; 1.30), with moderate certainty in the effect estimates by GRADE assessment. Of the nine identified observational studies, six were excluded due to a critical risk of bias in accordance with ROBINS-I. Among the included observational studies, two studies found no association, whereas one case-control study identified an association between s-25OHD < 20 nmol/L and neural tube defects, with an adjusted odds ratio of 2.34 (95% CI: 1.07; 5.07). Interpretation of the results should be cautious given the low prevalence of CAs, RCTs with onset of supplementation after organogenesis, and low-quality observational studies. MDPI 2023-04-28 /pmc/articles/PMC10181330/ /pubmed/37432271 http://dx.doi.org/10.3390/nu15092125 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Walker, Karen Christina
Thorsteinsdottir, Fanney
Christesen, Henrik Thybo
Hjortdal, Vibeke Elisabeth
Heitmann, Berit Lilienthal
Specht, Ina Olmer
Händel, Mina Nicole
Vitamin D Supplementation and Vitamin D Status during Pregnancy and the Risk of Congenital Anomalies—A Systematic Review and Meta-Analysis
title Vitamin D Supplementation and Vitamin D Status during Pregnancy and the Risk of Congenital Anomalies—A Systematic Review and Meta-Analysis
title_full Vitamin D Supplementation and Vitamin D Status during Pregnancy and the Risk of Congenital Anomalies—A Systematic Review and Meta-Analysis
title_fullStr Vitamin D Supplementation and Vitamin D Status during Pregnancy and the Risk of Congenital Anomalies—A Systematic Review and Meta-Analysis
title_full_unstemmed Vitamin D Supplementation and Vitamin D Status during Pregnancy and the Risk of Congenital Anomalies—A Systematic Review and Meta-Analysis
title_short Vitamin D Supplementation and Vitamin D Status during Pregnancy and the Risk of Congenital Anomalies—A Systematic Review and Meta-Analysis
title_sort vitamin d supplementation and vitamin d status during pregnancy and the risk of congenital anomalies—a systematic review and meta-analysis
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181330/
https://www.ncbi.nlm.nih.gov/pubmed/37432271
http://dx.doi.org/10.3390/nu15092125
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