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Transplacental Transport of Artificial Sweeteners

The prevalence of obesity is increasing, and the origins of obesity and metabolic dysfunction may be traced back to fetal life. Currently, overweight pregnant women are advised to substitute sugar-sweetened beverages with diet drinks containing artificial sweeteners. Recent evidence suggests that th...

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Autores principales: Leth-Møller, Magnus, Duvald, Christina Søndergaard, Stampe, Sofie, Greibe, Eva, Hoffmann-Lücke, Elke, Pedersen, Michael, Ovesen, Per Glud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181363/
https://www.ncbi.nlm.nih.gov/pubmed/37432196
http://dx.doi.org/10.3390/nu15092063
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author Leth-Møller, Magnus
Duvald, Christina Søndergaard
Stampe, Sofie
Greibe, Eva
Hoffmann-Lücke, Elke
Pedersen, Michael
Ovesen, Per Glud
author_facet Leth-Møller, Magnus
Duvald, Christina Søndergaard
Stampe, Sofie
Greibe, Eva
Hoffmann-Lücke, Elke
Pedersen, Michael
Ovesen, Per Glud
author_sort Leth-Møller, Magnus
collection PubMed
description The prevalence of obesity is increasing, and the origins of obesity and metabolic dysfunction may be traced back to fetal life. Currently, overweight pregnant women are advised to substitute sugar-sweetened beverages with diet drinks containing artificial sweeteners. Recent evidence suggests that the consumption of artificial sweeteners during pregnancy increases the risk of obesity in the child, but the mechanism is unknown. We hypothesized the transportation of artificial sweeteners across the placenta into the fetal circulation and the amniotic fluid. We included 19 pregnant women who were given an oral dose of acesulfame, cyclamate, saccharin, and sucralose immediately before a planned caesarean section. Nine women were included as controls, and they refrained from an intake of artificial sweeteners. The maternal and fetal blood and amniotic fluid were collected during the caesarean section, and concentrations of artificial sweeteners were measured using mass spectrometry. We found a linear relationship between the fetal plasma concentrations of artificial sweeteners and the maternal plasma concentrations, with adjusted coefficients of 0.49 (95% CI: 0.28–0.70) for acesulfame, 0.72 (95% CI: 0.48–0.95) for cyclamate, 0.51 (95% CI: 0.38–0.67) for saccharin, and 0.44 (95% CI: 0.33–0.55) for sucralose. We found no linear relationship between amniotic fluid and fetal plasma concentrations, but there were positive ratios for all four sweeteners. In conclusion, the four sweeteners investigated all crossed the placenta and were present in the fetal circulation and amniotic fluid.
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spelling pubmed-101813632023-05-13 Transplacental Transport of Artificial Sweeteners Leth-Møller, Magnus Duvald, Christina Søndergaard Stampe, Sofie Greibe, Eva Hoffmann-Lücke, Elke Pedersen, Michael Ovesen, Per Glud Nutrients Article The prevalence of obesity is increasing, and the origins of obesity and metabolic dysfunction may be traced back to fetal life. Currently, overweight pregnant women are advised to substitute sugar-sweetened beverages with diet drinks containing artificial sweeteners. Recent evidence suggests that the consumption of artificial sweeteners during pregnancy increases the risk of obesity in the child, but the mechanism is unknown. We hypothesized the transportation of artificial sweeteners across the placenta into the fetal circulation and the amniotic fluid. We included 19 pregnant women who were given an oral dose of acesulfame, cyclamate, saccharin, and sucralose immediately before a planned caesarean section. Nine women were included as controls, and they refrained from an intake of artificial sweeteners. The maternal and fetal blood and amniotic fluid were collected during the caesarean section, and concentrations of artificial sweeteners were measured using mass spectrometry. We found a linear relationship between the fetal plasma concentrations of artificial sweeteners and the maternal plasma concentrations, with adjusted coefficients of 0.49 (95% CI: 0.28–0.70) for acesulfame, 0.72 (95% CI: 0.48–0.95) for cyclamate, 0.51 (95% CI: 0.38–0.67) for saccharin, and 0.44 (95% CI: 0.33–0.55) for sucralose. We found no linear relationship between amniotic fluid and fetal plasma concentrations, but there were positive ratios for all four sweeteners. In conclusion, the four sweeteners investigated all crossed the placenta and were present in the fetal circulation and amniotic fluid. MDPI 2023-04-25 /pmc/articles/PMC10181363/ /pubmed/37432196 http://dx.doi.org/10.3390/nu15092063 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Leth-Møller, Magnus
Duvald, Christina Søndergaard
Stampe, Sofie
Greibe, Eva
Hoffmann-Lücke, Elke
Pedersen, Michael
Ovesen, Per Glud
Transplacental Transport of Artificial Sweeteners
title Transplacental Transport of Artificial Sweeteners
title_full Transplacental Transport of Artificial Sweeteners
title_fullStr Transplacental Transport of Artificial Sweeteners
title_full_unstemmed Transplacental Transport of Artificial Sweeteners
title_short Transplacental Transport of Artificial Sweeteners
title_sort transplacental transport of artificial sweeteners
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181363/
https://www.ncbi.nlm.nih.gov/pubmed/37432196
http://dx.doi.org/10.3390/nu15092063
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