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Interactions of Nanomaterials with Gut Microbiota and Their Applications in Cancer Therapy
Cancer treatment is a challenge by its incredible complexity. As a key driver and player of cancer, gut microbiota influences the efficacy of cancer treatment. Modalities to manipulate gut microbiota have been reported to enhance antitumor efficacy in some cases. Nanomaterials (NMs) have been compre...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181640/ https://www.ncbi.nlm.nih.gov/pubmed/37177631 http://dx.doi.org/10.3390/s23094428 |
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author | Li, Xiaohui Wei, Huan Qi, Jiachen Ma, Ke Luo, Yucheng Weng, Lixing |
author_facet | Li, Xiaohui Wei, Huan Qi, Jiachen Ma, Ke Luo, Yucheng Weng, Lixing |
author_sort | Li, Xiaohui |
collection | PubMed |
description | Cancer treatment is a challenge by its incredible complexity. As a key driver and player of cancer, gut microbiota influences the efficacy of cancer treatment. Modalities to manipulate gut microbiota have been reported to enhance antitumor efficacy in some cases. Nanomaterials (NMs) have been comprehensively applied in cancer diagnosis, imaging, and theranostics due to their unique and excellent properties, and their effectiveness is also influenced by gut microbiota. Nanotechnology is capable of targeting and manipulating gut microbiota, which offers massive opportunities to potentiate cancer treatment. Given the complexity of gut microbiota–host interactions, understanding NMs–gut interactions and NMs–gut microbiota interactions are important for applying nanotechnologies towards manipulating gut microbiota in cancer prevention and treatment. In this review, we provide an overview of NMs–gut interactions and NMs–gut microbiota interactions and highlight the influences of gut microbiota on the diagnosis and treatment effects of NMs, further illustrating the potential of nanotechnologies in cancer therapy. Investigation of the influences of NMs on cancer from the perspective of gut microbiota will boost the prospect of nanotechnology intervention of gut microbiota for cancer therapy. |
format | Online Article Text |
id | pubmed-10181640 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101816402023-05-13 Interactions of Nanomaterials with Gut Microbiota and Their Applications in Cancer Therapy Li, Xiaohui Wei, Huan Qi, Jiachen Ma, Ke Luo, Yucheng Weng, Lixing Sensors (Basel) Review Cancer treatment is a challenge by its incredible complexity. As a key driver and player of cancer, gut microbiota influences the efficacy of cancer treatment. Modalities to manipulate gut microbiota have been reported to enhance antitumor efficacy in some cases. Nanomaterials (NMs) have been comprehensively applied in cancer diagnosis, imaging, and theranostics due to their unique and excellent properties, and their effectiveness is also influenced by gut microbiota. Nanotechnology is capable of targeting and manipulating gut microbiota, which offers massive opportunities to potentiate cancer treatment. Given the complexity of gut microbiota–host interactions, understanding NMs–gut interactions and NMs–gut microbiota interactions are important for applying nanotechnologies towards manipulating gut microbiota in cancer prevention and treatment. In this review, we provide an overview of NMs–gut interactions and NMs–gut microbiota interactions and highlight the influences of gut microbiota on the diagnosis and treatment effects of NMs, further illustrating the potential of nanotechnologies in cancer therapy. Investigation of the influences of NMs on cancer from the perspective of gut microbiota will boost the prospect of nanotechnology intervention of gut microbiota for cancer therapy. MDPI 2023-04-30 /pmc/articles/PMC10181640/ /pubmed/37177631 http://dx.doi.org/10.3390/s23094428 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Li, Xiaohui Wei, Huan Qi, Jiachen Ma, Ke Luo, Yucheng Weng, Lixing Interactions of Nanomaterials with Gut Microbiota and Their Applications in Cancer Therapy |
title | Interactions of Nanomaterials with Gut Microbiota and Their Applications in Cancer Therapy |
title_full | Interactions of Nanomaterials with Gut Microbiota and Their Applications in Cancer Therapy |
title_fullStr | Interactions of Nanomaterials with Gut Microbiota and Their Applications in Cancer Therapy |
title_full_unstemmed | Interactions of Nanomaterials with Gut Microbiota and Their Applications in Cancer Therapy |
title_short | Interactions of Nanomaterials with Gut Microbiota and Their Applications in Cancer Therapy |
title_sort | interactions of nanomaterials with gut microbiota and their applications in cancer therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181640/ https://www.ncbi.nlm.nih.gov/pubmed/37177631 http://dx.doi.org/10.3390/s23094428 |
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