MHC class I and MHC class II reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis

Oligodendrocytes and their progenitors upregulate MHC pathways in response to inflammation, but the frequency of this phenotypic change is unknown and the features of these immune oligodendroglia are poorly defined. We generated MHC class I and II transgenic reporter mice to define their dynamics in...

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Detalles Bibliográficos
Autores principales: Harrington, Em P, Catenacci, Riley B, Smith, Matthew D, Heo, Dongeun, Miller, Cecilia E, Meyers, Keya R, Glatzer, Jenna, Bergles, Dwight E, Calabresi, Peter A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181822/
https://www.ncbi.nlm.nih.gov/pubmed/37057892
http://dx.doi.org/10.7554/eLife.82938
Descripción
Sumario:Oligodendrocytes and their progenitors upregulate MHC pathways in response to inflammation, but the frequency of this phenotypic change is unknown and the features of these immune oligodendroglia are poorly defined. We generated MHC class I and II transgenic reporter mice to define their dynamics in response to inflammatory demyelination, providing a means to monitor MHC activation in diverse cell types in living mice and define their roles in aging, injury, and disease.

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