MHC class I and MHC class II reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis

Oligodendrocytes and their progenitors upregulate MHC pathways in response to inflammation, but the frequency of this phenotypic change is unknown and the features of these immune oligodendroglia are poorly defined. We generated MHC class I and II transgenic reporter mice to define their dynamics in...

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Autores principales: Harrington, Em P, Catenacci, Riley B, Smith, Matthew D, Heo, Dongeun, Miller, Cecilia E, Meyers, Keya R, Glatzer, Jenna, Bergles, Dwight E, Calabresi, Peter A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181822/
https://www.ncbi.nlm.nih.gov/pubmed/37057892
http://dx.doi.org/10.7554/eLife.82938
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author Harrington, Em P
Catenacci, Riley B
Smith, Matthew D
Heo, Dongeun
Miller, Cecilia E
Meyers, Keya R
Glatzer, Jenna
Bergles, Dwight E
Calabresi, Peter A
author_facet Harrington, Em P
Catenacci, Riley B
Smith, Matthew D
Heo, Dongeun
Miller, Cecilia E
Meyers, Keya R
Glatzer, Jenna
Bergles, Dwight E
Calabresi, Peter A
author_sort Harrington, Em P
collection PubMed
description Oligodendrocytes and their progenitors upregulate MHC pathways in response to inflammation, but the frequency of this phenotypic change is unknown and the features of these immune oligodendroglia are poorly defined. We generated MHC class I and II transgenic reporter mice to define their dynamics in response to inflammatory demyelination, providing a means to monitor MHC activation in diverse cell types in living mice and define their roles in aging, injury, and disease.
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spelling pubmed-101818222023-05-13 MHC class I and MHC class II reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis Harrington, Em P Catenacci, Riley B Smith, Matthew D Heo, Dongeun Miller, Cecilia E Meyers, Keya R Glatzer, Jenna Bergles, Dwight E Calabresi, Peter A eLife Immunology and Inflammation Oligodendrocytes and their progenitors upregulate MHC pathways in response to inflammation, but the frequency of this phenotypic change is unknown and the features of these immune oligodendroglia are poorly defined. We generated MHC class I and II transgenic reporter mice to define their dynamics in response to inflammatory demyelination, providing a means to monitor MHC activation in diverse cell types in living mice and define their roles in aging, injury, and disease. eLife Sciences Publications, Ltd 2023-04-14 /pmc/articles/PMC10181822/ /pubmed/37057892 http://dx.doi.org/10.7554/eLife.82938 Text en © 2023, Harrington, Catenacci et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Immunology and Inflammation
Harrington, Em P
Catenacci, Riley B
Smith, Matthew D
Heo, Dongeun
Miller, Cecilia E
Meyers, Keya R
Glatzer, Jenna
Bergles, Dwight E
Calabresi, Peter A
MHC class I and MHC class II reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis
title MHC class I and MHC class II reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis
title_full MHC class I and MHC class II reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis
title_fullStr MHC class I and MHC class II reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis
title_full_unstemmed MHC class I and MHC class II reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis
title_short MHC class I and MHC class II reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis
title_sort mhc class i and mhc class ii reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis
topic Immunology and Inflammation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181822/
https://www.ncbi.nlm.nih.gov/pubmed/37057892
http://dx.doi.org/10.7554/eLife.82938
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