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Cross-sectional evaluation of the saccharin transit time test for primary ciliary dyskinesia: did we discard this tool too soon?

BACKGROUND: Primary ciliary dyskinesia (PCD) is a rare and heterogeneous disease that is difficult to diagnose and requires complex and expensive diagnostic tools. The saccharin transit time test is a simple and inexpensive tool that may assist in screening patients with PCD. OBJECTIVES: This study...

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Autores principales: Toro, Mariana Dalbo Contrera, Ortiz, Erica, Marson, Fernando Augusto Lima, Pinheiro, Laíza Mohana, Toro, Adyléia Aparecida Dalbo Contrera, Ribeiro, José Dirceu, Sakano, Eulália
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Paulista de Medicina - APM 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181835/
https://www.ncbi.nlm.nih.gov/pubmed/37194765
http://dx.doi.org/10.1590/1516-3180.2022.0508.R2.13032023
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author Toro, Mariana Dalbo Contrera
Ortiz, Erica
Marson, Fernando Augusto Lima
Pinheiro, Laíza Mohana
Toro, Adyléia Aparecida Dalbo Contrera
Ribeiro, José Dirceu
Sakano, Eulália
author_facet Toro, Mariana Dalbo Contrera
Ortiz, Erica
Marson, Fernando Augusto Lima
Pinheiro, Laíza Mohana
Toro, Adyléia Aparecida Dalbo Contrera
Ribeiro, José Dirceu
Sakano, Eulália
author_sort Toro, Mariana Dalbo Contrera
collection PubMed
description BACKGROUND: Primary ciliary dyskinesia (PCD) is a rare and heterogeneous disease that is difficult to diagnose and requires complex and expensive diagnostic tools. The saccharin transit time test is a simple and inexpensive tool that may assist in screening patients with PCD. OBJECTIVES: This study aimed to compare changes in the electron microscopy findings with clinical variables and saccharin tests in individuals diagnosed with clinical PCD (cPCD) and a control group. DESIGN AND SETTING: An observational cross-sectional study was conducted in an otorhinolaryngology outpatient clinic from August 2012 to April 2021. METHOD: Patients with cPCD underwent clinical screening questionnaires, nasal endoscopy, the saccharin transit time test, and nasal biopsy for transmission electron microscopy. RESULTS: Thirty-four patients with cPCD were evaluated. The most prevalent clinical comorbidities in the cPCD group were recurrent pneumonia, bronchiectasis, and chronic rhinosinusitis. Electron microscopy confirmed the clinical diagnosis of PCD in 16 of the 34 (47.1%) patients. CONCLUSION: The saccharin test could assist in screening patients with PCD due to its association with clinical alterations related to PCD.
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spelling pubmed-101818352023-05-13 Cross-sectional evaluation of the saccharin transit time test for primary ciliary dyskinesia: did we discard this tool too soon? Toro, Mariana Dalbo Contrera Ortiz, Erica Marson, Fernando Augusto Lima Pinheiro, Laíza Mohana Toro, Adyléia Aparecida Dalbo Contrera Ribeiro, José Dirceu Sakano, Eulália Sao Paulo Med J Original Article BACKGROUND: Primary ciliary dyskinesia (PCD) is a rare and heterogeneous disease that is difficult to diagnose and requires complex and expensive diagnostic tools. The saccharin transit time test is a simple and inexpensive tool that may assist in screening patients with PCD. OBJECTIVES: This study aimed to compare changes in the electron microscopy findings with clinical variables and saccharin tests in individuals diagnosed with clinical PCD (cPCD) and a control group. DESIGN AND SETTING: An observational cross-sectional study was conducted in an otorhinolaryngology outpatient clinic from August 2012 to April 2021. METHOD: Patients with cPCD underwent clinical screening questionnaires, nasal endoscopy, the saccharin transit time test, and nasal biopsy for transmission electron microscopy. RESULTS: Thirty-four patients with cPCD were evaluated. The most prevalent clinical comorbidities in the cPCD group were recurrent pneumonia, bronchiectasis, and chronic rhinosinusitis. Electron microscopy confirmed the clinical diagnosis of PCD in 16 of the 34 (47.1%) patients. CONCLUSION: The saccharin test could assist in screening patients with PCD due to its association with clinical alterations related to PCD. Associação Paulista de Medicina - APM 2023-05-12 /pmc/articles/PMC10181835/ /pubmed/37194765 http://dx.doi.org/10.1590/1516-3180.2022.0508.R2.13032023 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Original Article
Toro, Mariana Dalbo Contrera
Ortiz, Erica
Marson, Fernando Augusto Lima
Pinheiro, Laíza Mohana
Toro, Adyléia Aparecida Dalbo Contrera
Ribeiro, José Dirceu
Sakano, Eulália
Cross-sectional evaluation of the saccharin transit time test for primary ciliary dyskinesia: did we discard this tool too soon?
title Cross-sectional evaluation of the saccharin transit time test for primary ciliary dyskinesia: did we discard this tool too soon?
title_full Cross-sectional evaluation of the saccharin transit time test for primary ciliary dyskinesia: did we discard this tool too soon?
title_fullStr Cross-sectional evaluation of the saccharin transit time test for primary ciliary dyskinesia: did we discard this tool too soon?
title_full_unstemmed Cross-sectional evaluation of the saccharin transit time test for primary ciliary dyskinesia: did we discard this tool too soon?
title_short Cross-sectional evaluation of the saccharin transit time test for primary ciliary dyskinesia: did we discard this tool too soon?
title_sort cross-sectional evaluation of the saccharin transit time test for primary ciliary dyskinesia: did we discard this tool too soon?
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181835/
https://www.ncbi.nlm.nih.gov/pubmed/37194765
http://dx.doi.org/10.1590/1516-3180.2022.0508.R2.13032023
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