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Auxiliary-Cavity-Induced Ultrasensitive and Ultrahigh-Resolution Biomolecule Mass Sensing in a Hybrid Spinning Resonator System
We theoretically demonstrate an ultrasensitive and ultrahigh-resolution biomolecule mass sensing based on a spinning resonator system, which includes a spinning whispering-gallery-mode (WGM) optomechanical cavity and an auxiliary optical cavity. When the WGM cavity is spinning along the clockwise or...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer International Publishing
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181922/ http://dx.doi.org/10.1007/s10946-023-10119-9 |
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author | Chen, Hua-Jun |
author_facet | Chen, Hua-Jun |
author_sort | Chen, Hua-Jun |
collection | PubMed |
description | We theoretically demonstrate an ultrasensitive and ultrahigh-resolution biomolecule mass sensing based on a spinning resonator system, which includes a spinning whispering-gallery-mode (WGM) optomechanical cavity and an auxiliary optical cavity. When the WGM cavity is spinning along the clockwise or counterclockwise direction, the cavity field will undergo different Sagnac effect. If the Sagnac effect and the auxiliary optical cavity are simultaneously taken into consideration, not only the line width of the transmission spectrum is significantly squeezed, but also the transmission intensity will be extremely enhanced, which indicates an ultrasensitive and ultrahigh-resolution mass sensor. When the mass of external biomolecules (such as baculovirus or coronavirus) is deposited on the resonator, their mass can be determined by tracking the resonance frequency shifts in the transmission spectrum. Thus, our research can provide a method to classify kinds of viruses, especially can be used to identify 2019-nCoV. |
format | Online Article Text |
id | pubmed-10181922 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-101819222023-05-14 Auxiliary-Cavity-Induced Ultrasensitive and Ultrahigh-Resolution Biomolecule Mass Sensing in a Hybrid Spinning Resonator System Chen, Hua-Jun J Russ Laser Res Article We theoretically demonstrate an ultrasensitive and ultrahigh-resolution biomolecule mass sensing based on a spinning resonator system, which includes a spinning whispering-gallery-mode (WGM) optomechanical cavity and an auxiliary optical cavity. When the WGM cavity is spinning along the clockwise or counterclockwise direction, the cavity field will undergo different Sagnac effect. If the Sagnac effect and the auxiliary optical cavity are simultaneously taken into consideration, not only the line width of the transmission spectrum is significantly squeezed, but also the transmission intensity will be extremely enhanced, which indicates an ultrasensitive and ultrahigh-resolution mass sensor. When the mass of external biomolecules (such as baculovirus or coronavirus) is deposited on the resonator, their mass can be determined by tracking the resonance frequency shifts in the transmission spectrum. Thus, our research can provide a method to classify kinds of viruses, especially can be used to identify 2019-nCoV. Springer International Publishing 2023-05-13 2023 /pmc/articles/PMC10181922/ http://dx.doi.org/10.1007/s10946-023-10119-9 Text en © Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Chen, Hua-Jun Auxiliary-Cavity-Induced Ultrasensitive and Ultrahigh-Resolution Biomolecule Mass Sensing in a Hybrid Spinning Resonator System |
title | Auxiliary-Cavity-Induced Ultrasensitive and Ultrahigh-Resolution Biomolecule Mass Sensing in a Hybrid Spinning Resonator System |
title_full | Auxiliary-Cavity-Induced Ultrasensitive and Ultrahigh-Resolution Biomolecule Mass Sensing in a Hybrid Spinning Resonator System |
title_fullStr | Auxiliary-Cavity-Induced Ultrasensitive and Ultrahigh-Resolution Biomolecule Mass Sensing in a Hybrid Spinning Resonator System |
title_full_unstemmed | Auxiliary-Cavity-Induced Ultrasensitive and Ultrahigh-Resolution Biomolecule Mass Sensing in a Hybrid Spinning Resonator System |
title_short | Auxiliary-Cavity-Induced Ultrasensitive and Ultrahigh-Resolution Biomolecule Mass Sensing in a Hybrid Spinning Resonator System |
title_sort | auxiliary-cavity-induced ultrasensitive and ultrahigh-resolution biomolecule mass sensing in a hybrid spinning resonator system |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181922/ http://dx.doi.org/10.1007/s10946-023-10119-9 |
work_keys_str_mv | AT chenhuajun auxiliarycavityinducedultrasensitiveandultrahighresolutionbiomoleculemasssensinginahybridspinningresonatorsystem |