Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells

Extrachromosomal DNAs (ecDNAs) are common in cancer, but many questions about their origin, structural dynamics and impact on intratumor heterogeneity are still unresolved. Here we describe single-cell extrachromosomal circular DNA and transcriptome sequencing (scEC&T-seq), a method for parallel...

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Detalles Bibliográficos
Autores principales: Chamorro González, Rocío, Conrad, Thomas, Stöber, Maja C., Xu, Robin, Giurgiu, Mădălina, Rodriguez-Fos, Elias, Kasack, Katharina, Brückner, Lotte, van Leen, Eric, Helmsauer, Konstantin, Dorado Garcia, Heathcliff, Stefanova, Maria E., Hung, King L., Bei, Yi, Schmelz, Karin, Lodrini, Marco, Mundlos, Stefan, Chang, Howard Y., Deubzer, Hedwig E., Sauer, Sascha, Eggert, Angelika, Schulte, Johannes H., Schwarz, Roland F., Haase, Kerstin, Koche, Richard P., Henssen, Anton G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Technical Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181933/
https://www.ncbi.nlm.nih.gov/pubmed/37142849
http://dx.doi.org/10.1038/s41588-023-01386-y

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