Atypical teratoid/rhabdoid tumoroids reveal subgroup-specific drug vulnerabilities

Atypical teratoid/rhabdoid tumors (ATRTs) represent a rare, but aggressive pediatric brain tumor entity. They are genetically defined by alterations in the SWI/SNF chromatin remodeling complex members SMARCB1 or SMARCA4. ATRTs can be further classified in different molecular subgroups based on their...

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Detalles Bibliográficos
Autores principales: Paassen, Irene, Williams, Justin, Ríos Arceo, Carla, Ringnalda, Femke, Mercer, Kimberly Shea, Buhl, Juliane L., Moreno, Natalia, Federico, Aniello, Franke, Niels E., Kranendonk, Mariette, Upadhyaya, Santhosh A., Kerl, Kornelius, van de Wetering, Marc, Clevers, Hans, Kool, Marcel, Hoving, Eelco W., Roussel, Martine F., Drost, Jarno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181938/
https://www.ncbi.nlm.nih.gov/pubmed/37020038
http://dx.doi.org/10.1038/s41388-023-02681-y

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