Single duplex DNA sequencing with CODEC detects mutations with high sensitivity

Detecting mutations from single DNA molecules is crucial in many fields but challenging. Next-generation sequencing (NGS) affords tremendous throughput but cannot directly sequence double-stranded DNA molecules (‘single duplexes’) to discern the true mutations on both strands. Here we present Concat...

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Detalles Bibliográficos
Autores principales: Bae, Jin H., Liu, Ruolin, Roberts, Eugenia, Nguyen, Erica, Tabrizi, Shervin, Rhoades, Justin, Blewett, Timothy, Xiong, Kan, Gydush, Gregory, Shea, Douglas, An, Zhenyi, Patel, Sahil, Cheng, Ju, Sridhar, Sainetra, Liu, Mei Hong, Lassen, Emilie, Skytte, Anne-Bine, Grońska-Pęski, Marta, Shoag, Jonathan E., Evrony, Gilad D., Parsons, Heather A., Mayer, Erica L., Makrigiorgos, G. Mike, Golub, Todd R., Adalsteinsson, Viktor A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Technical Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181940/
https://www.ncbi.nlm.nih.gov/pubmed/37106072
http://dx.doi.org/10.1038/s41588-023-01376-0

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