Neutrophil elastase decreases SARS-CoV-2 spike protein binding to human bronchial epithelia by clipping ACE-2 ectodomain from the epithelial surface

Patients with cystic fibrosis (CF) have decreased severity of severe acute respiratory syndrome-like coronavirus-2 (SARS-CoV-2) infections, but the underlying cause is unknown. Patients with CF have high levels of neutrophil elastase (NE) in the airway. We examined whether respiratory epithelial ang...

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Detalles Bibliográficos
Autores principales: Kummarapurugu, Apparao B., Hawkridge, Adam M., Ma, Jonathan, Osei, Stephanie, Martin, Rebecca K., Zheng, Shuo, Voynow, Judith A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181948/
https://www.ncbi.nlm.nih.gov/pubmed/37187291
http://dx.doi.org/10.1016/j.jbc.2023.104820

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