Neither Gastric Bypass Surgery Nor Diet-Induced Weight-Loss Affect OATP1B1 Activity as Measured by Rosuvastatin Oral Clearance

INTRODUCTION: Rosuvastatin pharmacokinetics is mainly dependent on the activity of hepatic uptake transporter OATP1B1. In this study, we aimed to investigate and disentangle the effect of Roux-en-Y gastric bypass (RYGB) and weight loss on oral clearance (CL/F) of rosuvastatin as a measure of OATP1B1...

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Detalles Bibliográficos
Autores principales: Hovd, Markus, Robertsen, Ida, Johnson, Line Kristin, Krogstad, Veronica, Wegler, Christine, Kvitne, Kine Eide, Kringen, Marianne Kristiansen, Skovlund, Eva, Karlsson, Cecilia, Andersson, Shalini, Artursson, Per, Sandbu, Rune, Hjelmesæth, Jøran, Åsberg, Anders, Jansson-Löfmark, Rasmus, Christensen, Hege
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181972/
https://www.ncbi.nlm.nih.gov/pubmed/36988826
http://dx.doi.org/10.1007/s40262-023-01235-5

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