Viability of internal comparisons for epidemiological research in the US astronaut corps

This study aims to determine whether astronauts who have not flown in space can provide an unbiased comparison to astronauts who have flown in space when analyzing long-term health outcomes such as incidence of chronic disease and mortality. Various propensity score methods failed to achieve good ba...

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Autores principales: Reynolds, Robert J., Day, Steven M., Kanikkannan, Lakshmi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181986/
https://www.ncbi.nlm.nih.gov/pubmed/37173308
http://dx.doi.org/10.1038/s41526-023-00278-z
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author Reynolds, Robert J.
Day, Steven M.
Kanikkannan, Lakshmi
author_facet Reynolds, Robert J.
Day, Steven M.
Kanikkannan, Lakshmi
author_sort Reynolds, Robert J.
collection PubMed
description This study aims to determine whether astronauts who have not flown in space can provide an unbiased comparison to astronauts who have flown in space when analyzing long-term health outcomes such as incidence of chronic disease and mortality. Various propensity score methods failed to achieve good balance between groups, demonstrating that even with sophisticated rebalancing methods the group of non-flight astronauts cannot be demonstrated to be an unbiased comparison group for examining the effect of the hazards of spaceflight on incidence and mortality from chronic diseases.
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spelling pubmed-101819862023-05-14 Viability of internal comparisons for epidemiological research in the US astronaut corps Reynolds, Robert J. Day, Steven M. Kanikkannan, Lakshmi NPJ Microgravity Brief Communication This study aims to determine whether astronauts who have not flown in space can provide an unbiased comparison to astronauts who have flown in space when analyzing long-term health outcomes such as incidence of chronic disease and mortality. Various propensity score methods failed to achieve good balance between groups, demonstrating that even with sophisticated rebalancing methods the group of non-flight astronauts cannot be demonstrated to be an unbiased comparison group for examining the effect of the hazards of spaceflight on incidence and mortality from chronic diseases. Nature Publishing Group UK 2023-05-12 /pmc/articles/PMC10181986/ /pubmed/37173308 http://dx.doi.org/10.1038/s41526-023-00278-z Text en © This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Reynolds, Robert J.
Day, Steven M.
Kanikkannan, Lakshmi
Viability of internal comparisons for epidemiological research in the US astronaut corps
title Viability of internal comparisons for epidemiological research in the US astronaut corps
title_full Viability of internal comparisons for epidemiological research in the US astronaut corps
title_fullStr Viability of internal comparisons for epidemiological research in the US astronaut corps
title_full_unstemmed Viability of internal comparisons for epidemiological research in the US astronaut corps
title_short Viability of internal comparisons for epidemiological research in the US astronaut corps
title_sort viability of internal comparisons for epidemiological research in the us astronaut corps
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181986/
https://www.ncbi.nlm.nih.gov/pubmed/37173308
http://dx.doi.org/10.1038/s41526-023-00278-z
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