Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response

With the continued promise of immunotherapy for treating cancer, understanding how host genetics contributes to the tumor immune microenvironment (TIME) is essential to tailoring cancer screening and treatment strategies. Here, we study 1084 eQTLs affecting the TIME found through analysis of The Can...

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Detalles Bibliográficos
Autores principales: Pagadala, Meghana, Sears, Timothy J., Wu, Victoria H., Pérez-Guijarro, Eva, Kim, Hyo, Castro, Andrea, Talwar, James V., Gonzalez-Colin, Cristian, Cao, Steven, Schmiedel, Benjamin J., Goudarzi, Shervin, Kirani, Divya, Au, Jessica, Zhang, Tongwu, Landi, Teresa, Salem, Rany M., Morris, Gerald P., Harismendy, Olivier, Patel, Sandip Pravin, Alexandrov, Ludmil B., Mesirov, Jill P., Zanetti, Maurizio, Day, Chi-Ping, Fan, Chun Chieh, Thompson, Wesley K., Merlino, Glenn, Gutkind, J. Silvio, Vijayanand, Pandurangan, Carter, Hannah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182072/
https://www.ncbi.nlm.nih.gov/pubmed/37173324
http://dx.doi.org/10.1038/s41467-023-38271-5

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