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Clinical research review: usefulness of bovine lactoferrin in child health
Lactoferrin (LF) is abundant in human milk and plays an important role in the health of children. Bovine LF (bLF) has high homology with human LF and has been reported to have multiple biological functions. Several clinical studies have been conducted considering these properties, which reported the...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182119/ https://www.ncbi.nlm.nih.gov/pubmed/35941293 http://dx.doi.org/10.1007/s10534-022-00430-4 |
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author | Miyakawa, Momoko Oda, Hirotsugu Tanaka, Miyuki |
author_facet | Miyakawa, Momoko Oda, Hirotsugu Tanaka, Miyuki |
author_sort | Miyakawa, Momoko |
collection | PubMed |
description | Lactoferrin (LF) is abundant in human milk and plays an important role in the health of children. Bovine LF (bLF) has high homology with human LF and has been reported to have multiple biological functions. Several clinical studies have been conducted considering these properties, which reported the usefulness of bLF. This review was aimed to provide an overview of the clinical evidence in children. We searched clinical reports investigating the effects of bLF in children and identified 36 studies on the role of bLF in infections, iron metabolism, body growth, cerebral development, and fecal microbiome. Considering the accumulated evidence, bLF may contribute to the child health, particularly by suppressing or alleviating gastrointestinal and respiratory symptoms, and improving the iron status of children with anemia or those at high risk of anemia. The dose of bLF varies depending on the expected effect and target age, but may not necessarily have to be as high as human LF in human milk. Some of the beneficial effects of bLF have not been fully validated due to limited clinical evidence or being observed in the secondary analysis of some studies. Further clinical evidence would add significant value to the use of bLF in child health. |
format | Online Article Text |
id | pubmed-10182119 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Netherlands |
record_format | MEDLINE/PubMed |
spelling | pubmed-101821192023-05-14 Clinical research review: usefulness of bovine lactoferrin in child health Miyakawa, Momoko Oda, Hirotsugu Tanaka, Miyuki Biometals Article Lactoferrin (LF) is abundant in human milk and plays an important role in the health of children. Bovine LF (bLF) has high homology with human LF and has been reported to have multiple biological functions. Several clinical studies have been conducted considering these properties, which reported the usefulness of bLF. This review was aimed to provide an overview of the clinical evidence in children. We searched clinical reports investigating the effects of bLF in children and identified 36 studies on the role of bLF in infections, iron metabolism, body growth, cerebral development, and fecal microbiome. Considering the accumulated evidence, bLF may contribute to the child health, particularly by suppressing or alleviating gastrointestinal and respiratory symptoms, and improving the iron status of children with anemia or those at high risk of anemia. The dose of bLF varies depending on the expected effect and target age, but may not necessarily have to be as high as human LF in human milk. Some of the beneficial effects of bLF have not been fully validated due to limited clinical evidence or being observed in the secondary analysis of some studies. Further clinical evidence would add significant value to the use of bLF in child health. Springer Netherlands 2022-08-09 2023 /pmc/articles/PMC10182119/ /pubmed/35941293 http://dx.doi.org/10.1007/s10534-022-00430-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/ Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Miyakawa, Momoko Oda, Hirotsugu Tanaka, Miyuki Clinical research review: usefulness of bovine lactoferrin in child health |
title | Clinical research review: usefulness of bovine lactoferrin in child health |
title_full | Clinical research review: usefulness of bovine lactoferrin in child health |
title_fullStr | Clinical research review: usefulness of bovine lactoferrin in child health |
title_full_unstemmed | Clinical research review: usefulness of bovine lactoferrin in child health |
title_short | Clinical research review: usefulness of bovine lactoferrin in child health |
title_sort | clinical research review: usefulness of bovine lactoferrin in child health |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182119/ https://www.ncbi.nlm.nih.gov/pubmed/35941293 http://dx.doi.org/10.1007/s10534-022-00430-4 |
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