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Hydrogen Sulphide-Based Therapeutics for Neurological Conditions: Perspectives and Challenges

Central nervous system (CNS)-related conditions are currently the leading cause of disability worldwide, posing a significant burden to health systems, individuals and their families. Although the molecular mechanisms implicated in these disorders may be varied, neurological conditions have been inc...

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Autores principales: Sharif, Amir H., Iqbal, Mohammed, Manhoosh, Bahareh, Gholampoor, Negin, Ma, Dan, Marwah, Mandeep, Sanchez-Aranguren, Lissette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182124/
https://www.ncbi.nlm.nih.gov/pubmed/36764968
http://dx.doi.org/10.1007/s11064-023-03887-y
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author Sharif, Amir H.
Iqbal, Mohammed
Manhoosh, Bahareh
Gholampoor, Negin
Ma, Dan
Marwah, Mandeep
Sanchez-Aranguren, Lissette
author_facet Sharif, Amir H.
Iqbal, Mohammed
Manhoosh, Bahareh
Gholampoor, Negin
Ma, Dan
Marwah, Mandeep
Sanchez-Aranguren, Lissette
author_sort Sharif, Amir H.
collection PubMed
description Central nervous system (CNS)-related conditions are currently the leading cause of disability worldwide, posing a significant burden to health systems, individuals and their families. Although the molecular mechanisms implicated in these disorders may be varied, neurological conditions have been increasingly associated with inflammation and/or impaired oxidative response leading to further neural cell damages. Therefore, therapeutic approaches targeting these defective molecular mechanisms have been vastly explored. Hydrogen sulphide (H(2)S) has emerged as a modulator of both inflammation and oxidative stress with a neuroprotective role, therefore, has gained interest in the treatment of neurological disorders. H(2)S, produced by endogenous sources, is maintained at low levels in the CNS. However, defects in the biosynthetic and catabolic routes for H(2)S metabolism have been identified in CNS-related disorders. Approaches to restore H(2)S availability using H(2)S-donating compounds have been recently explored in many models of neurological conditions. Nonetheless, we still need to elucidate the potential for these compounds not only to ameliorate defective biological routes, but also to better comprehend the implications on H(2)S delivery, dosage regimes and feasibility to successfully target CNS tissues. Here, we highlight the molecular mechanisms of H(2)S-dependent restoration of neurological functions in different models of CNS disease whilst summarising current administration approaches for these H(2)S-based compounds. We also address existing barriers in H(2)S donor delivery by showcasing current advances in mediating these constrains through novel biomaterial-based carriers for H(2)S donors.
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spelling pubmed-101821242023-05-14 Hydrogen Sulphide-Based Therapeutics for Neurological Conditions: Perspectives and Challenges Sharif, Amir H. Iqbal, Mohammed Manhoosh, Bahareh Gholampoor, Negin Ma, Dan Marwah, Mandeep Sanchez-Aranguren, Lissette Neurochem Res Review Central nervous system (CNS)-related conditions are currently the leading cause of disability worldwide, posing a significant burden to health systems, individuals and their families. Although the molecular mechanisms implicated in these disorders may be varied, neurological conditions have been increasingly associated with inflammation and/or impaired oxidative response leading to further neural cell damages. Therefore, therapeutic approaches targeting these defective molecular mechanisms have been vastly explored. Hydrogen sulphide (H(2)S) has emerged as a modulator of both inflammation and oxidative stress with a neuroprotective role, therefore, has gained interest in the treatment of neurological disorders. H(2)S, produced by endogenous sources, is maintained at low levels in the CNS. However, defects in the biosynthetic and catabolic routes for H(2)S metabolism have been identified in CNS-related disorders. Approaches to restore H(2)S availability using H(2)S-donating compounds have been recently explored in many models of neurological conditions. Nonetheless, we still need to elucidate the potential for these compounds not only to ameliorate defective biological routes, but also to better comprehend the implications on H(2)S delivery, dosage regimes and feasibility to successfully target CNS tissues. Here, we highlight the molecular mechanisms of H(2)S-dependent restoration of neurological functions in different models of CNS disease whilst summarising current administration approaches for these H(2)S-based compounds. We also address existing barriers in H(2)S donor delivery by showcasing current advances in mediating these constrains through novel biomaterial-based carriers for H(2)S donors. Springer US 2023-02-10 2023 /pmc/articles/PMC10182124/ /pubmed/36764968 http://dx.doi.org/10.1007/s11064-023-03887-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Sharif, Amir H.
Iqbal, Mohammed
Manhoosh, Bahareh
Gholampoor, Negin
Ma, Dan
Marwah, Mandeep
Sanchez-Aranguren, Lissette
Hydrogen Sulphide-Based Therapeutics for Neurological Conditions: Perspectives and Challenges
title Hydrogen Sulphide-Based Therapeutics for Neurological Conditions: Perspectives and Challenges
title_full Hydrogen Sulphide-Based Therapeutics for Neurological Conditions: Perspectives and Challenges
title_fullStr Hydrogen Sulphide-Based Therapeutics for Neurological Conditions: Perspectives and Challenges
title_full_unstemmed Hydrogen Sulphide-Based Therapeutics for Neurological Conditions: Perspectives and Challenges
title_short Hydrogen Sulphide-Based Therapeutics for Neurological Conditions: Perspectives and Challenges
title_sort hydrogen sulphide-based therapeutics for neurological conditions: perspectives and challenges
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182124/
https://www.ncbi.nlm.nih.gov/pubmed/36764968
http://dx.doi.org/10.1007/s11064-023-03887-y
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