Cargando…

Vancomycin Clearance in Obese Adults is not Predictive of Clearance in Obese Adolescents

BACKGROUND AND OBJECTIVE: Contradictory pharmacokinetic (PK) results have been observed between obese adults and obese adolescents, with absolute clearance (CL) reported to be either unaltered, lower, or higher in obese adolescents compared to obese adults. This study investigates the PK of vancomyc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Tan, Smit, Cornelis, Sherwin, Catherine M. T., Knibbe, Catherijne A. J., Krekels, Elke H. J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2023
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182161/ https://www.ncbi.nlm.nih.gov/pubmed/37017883 http://dx.doi.org/10.1007/s40262-023-01227-5

Ejemplares similares

Higher Midazolam Clearance in Obese Adolescents Compared with Morbidly Obese Adults
por: van Rongen, Anne, et al.
Publicado: (2017)

The Predictive Value of Glomerular Filtration Rate-Based Scaling of Pediatric Clearance and Doses for Drugs Eliminated by Glomerular Filtration with Varying Protein-Binding Properties
por: Cristea, Sinziana, et al.
Publicado: (2020)

Dosing Recommendations for Vancomycin in Children and Adolescents with Varying Levels of Obesity and Renal Dysfunction: a Population Pharmacokinetic Study in 1892 Children Aged 1–18 Years
por: Smit, Cornelis, et al.
Publicado: (2021)

Tobramycin Clearance Is Best Described by Renal Function Estimates in Obese and Non-obese Individuals: Results of a Prospective Rich Sampling Pharmacokinetic Study
por: Smit, Cornelis, et al.
Publicado: (2019)

Allometric Scaling of Clearance in Paediatric Patients: When Does the Magic of 0.75 Fade?
por: Calvier, Elisa A. M., et al.
Publicado: (2016)

A Pediatric Covariate Function for CYP3A-Mediated Midazolam Clearance Can Scale Clearance of Selected CYP3A Substrates in Children
por: Brussee, Janneke M., et al.
Publicado: (2019)

The Influence of Drug Properties and Ontogeny of Transporters on Pediatric Renal Clearance through Glomerular Filtration and Active Secretion: a Simulation-Based Study
por: Cristea, Sînziana, et al.
Publicado: (2020)

Can Population Modelling Principles be Used to Identify Key PBPK Parameters for Paediatric Clearance Predictions? An Innovative Application of Optimal Design Theory
por: Calvier, Elisa A. M., et al.
Publicado: (2018)

Increased Metformin Clearance in Overweight and Obese Adolescents: A Pharmacokinetic Substudy of a Randomized Controlled Trial
por: van Rongen, Anne, et al.
Publicado: (2018)

A Bodyweight-Dependent Allometric Exponent for Scaling Clearance Across the Human Life-Span
por: Wang, Chenguang, et al.
Publicado: (2012)

Population pharmacokinetics of vancomycin in obesity: Finding the optimal dose for (morbidly) obese individuals
por: Smit, Cornelis, et al.
Publicado: (2020)

Scaling Drug Clearance from Adults to the Young Children for Drugs Undergoing Hepatic Metabolism: A Simulation Study to Search for the Simplest Scaling Method
por: Calvier, E. A. M., et al.
Publicado: (2019)

Ciprofloxacin Pharmacokinetics After Oral and Intravenous Administration in (Morbidly) Obese and Non-obese Individuals: A Prospective Clinical Study
por: van Rhee, Koen P., et al.
Publicado: (2022)

1091. Validation of an Allometrically Scaled Body Weight Equation to Predict Vancomycin Clearance and Guide 24-Hour Vancomycin AUC Dosing in Obese Patients
por: Footer, Brent, et al.
Publicado: (2021)

Children Are Not Small Adults, but Can We Treat Them As Such?
por: Krekels, Elke H.J., et al.
Publicado: (2019)

Hyperinsulinemia in Individuals with obesity: Role of Insulin Clearance
por: Kim, Mee Kyoung, et al.
Publicado: (2015)

Systematic Evaluation of the Descriptive and Predictive Performance of Paediatric Morphine Population Models
por: Krekels, Elke H. J., et al.
Publicado: (2010)

Insulin Clearance in Obesity and Type 2 Diabetes
por: Koh, Han-Chow E., et al.
Publicado: (2022)

Predictors of Insulin Resistance in Children versus Adolescents with Obesity
por: Lentferink, Yvette E., et al.
Publicado: (2017)

Increased Arterial Stiffness in Adolescents With Obesity
por: Lentferink, Yvette E., et al.
Publicado: (2019)

Variability in vancomycin levels in an intensive care population explained by variability in clearance
por: Lans, PJ, et al.
Publicado: (2015)

Gut microbiota impairs insulin clearance in obese mice
por: Foley, Kevin P., et al.
Publicado: (2020)

Vagotomy Reduces Insulin Clearance in Obese Mice Programmed by Low-Protein Diet in the Adolescence
por: Lubaczeuski, Camila, et al.
Publicado: (2017)

Delayed SARS-CoV-2 Clearance in Patients with Obesity
por: Zhang, Xiujun, et al.
Publicado: (2021)

Enhanced renal clearance and impact on vancomycin pharmacokinetic parameters in patients with hemorrhagic stroke
por: Morbitzer, Kathryn A., et al.
Publicado: (2019)

Dose recommendations for gentamicin in the real-world obese population with varying body weight and renal (dys)function
por: Smit, Cornelis, et al.
Publicado: (2020)

A Prospective Clinical Study Characterizing the Influence of Morbid Obesity on the Pharmacokinetics of Gentamicin: Towards Individualized Dosing in Obese Patients
por: Smit, Cornelis, et al.
Publicado: (2019)

Over-increased creatinine renal clearance in septic patients and implications for vancomycin optimization
por: Baptista, J, et al.
Publicado: (2009)

Delayed clearance of triglyceride‐rich lipoproteins in young, healthy obese subjects
por: Larsen, M. A., et al.
Publicado: (2015)

Implications for IV posaconazole dosing in the era of obesity
por: Wasmann, Roeland E, et al.
Publicado: (2020)

Overestimation of Vancomycin Clearance by the Linear Regression Formula in Rodvold's Report: Why?
por: Yim, Dong-Seok
Publicado: (2014)

Determination of vancomycin and gentamicin clearance in an in vitro, closed loop dialysis system
por: Jang, Soo Min, et al.
Publicado: (2014)

64. Novel Biomarkers Improve Estimation of Vancomycin Clearance in Critically Ill Children
por: Downes, Kevin J, et al.
Publicado: (2021)

The effect of body mass index and creatinine clearance on serum trough concentration of vancomycin in adult patients
por: Pan, Yuyan, et al.
Publicado: (2020)

Towards Evidence-Based Weaning: a Mechanism-Based Pharmacometric Model to Characterize Iatrogenic Withdrawal Syndrome in Critically Ill Children
por: Goulooze, Sebastiaan C., et al.
Publicado: (2021)

Evaluation of propofol anesthesia in morbidly obese children and adolescents
por: Chidambaran, Vidya, et al.
Publicado: (2013)

LBODP083 Pharmacokinetics Of Metformin In Obese Non-diabetic Youth: Drug Clearance Increases With Severity Of Obesity
por: Halpin, Kelsee, et al.
Publicado: (2022)

Insulin Clearance at the Pubertal Transition in Youth with Obesity and Steatosis Liver Disease
por: Franceschi, Roberto, et al.
Publicado: (2023)

Correlates of insulin clearance in apparently healthy non-obese Japanese men
por: Kaga, Hideyoshi, et al.
Publicado: (2017)

Fixed Dosing of Liposomal Amphotericin B in Morbidly Obese Individuals
por: Wasmann, Roeland E, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_5r1k12lhc9q59m3p6jt1mrcb54