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Genome-wide CRISPR/Cas9 screen identifies etoposide response modulators associated with clinical outcomes in pediatric AML

Etoposide is used to treat a wide range of malignant cancers, including acute myeloid leukemia (AML) in children. Despite the use of intensive chemotherapeutic regimens containing etoposide, a significant proportion of pediatric patients with AML become resistant to treatment and relapse, leading to...

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Detalles Bibliográficos
Autores principales:	Nguyen, Nam H. K., Rafiee, Roya, Tagmount, Abderrahmane, Sobh, Amin, Loguinov, Alex, de Jesus Sosa, Angelica K., Elsayed, Abdelrahman H., Gbadamosi, Mohammed, Seligson, Nathan, Cogle, Christopher R., Rubnitz, Jeffery, Ribeiro, Raul, Downing, James, Cao, Xueyuan, Pounds, Stanley B., Vulpe, Christopher D., Lamba, Jatinder K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society of Hematology 2022
Materias:	Myeloid Neoplasia
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182178/ https://www.ncbi.nlm.nih.gov/pubmed/36111891 http://dx.doi.org/10.1182/bloodadvances.2022007934

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