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Activation priming and cytokine polyfunctionality modulate the enhanced functionality of low-affinity CD19 CAR T cells

We recently described a low-affinity second-generation CD19 chimeric antigen receptor (CAR) CAT that showed enhanced expansion, cytotoxicity, and antitumor efficacy compared with the high-affinity (FMC63-based) CAR used in tisagenlecleucel, in preclinical models. Furthermore, CAT demonstrated an exc...

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Detalles Bibliográficos
Autores principales:	Michelozzi, Ilaria M., Gomez-Castaneda, Eduardo, Pohle, Ruben V. C., Cardoso Rodriguez, Ferran, Sufi, Jahangir, Puigdevall Costa, Pau, Subramaniyam, Meera, Kirtsios, Efstratios, Eddaoudi, Ayad, Wu, Si Wei, Guvenel, Aleks, Fisher, Jonathan, Ghorashian, Sara, Pule, Martin A., Tape, Christopher J., Castellano, Sergi, Amrolia, Persis J., Giustacchini, Alice
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society of Hematology 2022
Materias:	Immunobiology and Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182295/ https://www.ncbi.nlm.nih.gov/pubmed/36453632 http://dx.doi.org/10.1182/bloodadvances.2022008490

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